RU2585228C2 - Модификация рекомбинантного аденовируса иммуногенными эпитопами белка circumsporozoite плазмодия - Google Patents

Модификация рекомбинантного аденовируса иммуногенными эпитопами белка circumsporozoite плазмодия Download PDF

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RU2585228C2
RU2585228C2 RU2012110255/10A RU2012110255A RU2585228C2 RU 2585228 C2 RU2585228 C2 RU 2585228C2 RU 2012110255/10 A RU2012110255/10 A RU 2012110255/10A RU 2012110255 A RU2012110255 A RU 2012110255A RU 2585228 C2 RU2585228 C2 RU 2585228C2
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adenovirus
protein
seq
sequence
modified
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RU2012110255A (ru
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Такаюки СИРАЦУТИ
Мория Цудзи
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Дзе Рокфеллер Юниверсити
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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    • A—HUMAN NECESSITIES
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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RU2012110255/10A 2009-08-18 2010-08-18 Модификация рекомбинантного аденовируса иммуногенными эпитопами белка circumsporozoite плазмодия RU2585228C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2009/054212 WO2011022002A1 (en) 2009-08-18 2009-08-18 Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
USPCT/US2009/054212 2009-08-18
PCT/US2010/045952 WO2011022522A1 (en) 2009-08-18 2010-08-18 Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes

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RU2012110255A RU2012110255A (ru) 2013-09-27
RU2585228C2 true RU2585228C2 (ru) 2016-05-27

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RU2012110255/10A RU2585228C2 (ru) 2009-08-18 2010-08-18 Модификация рекомбинантного аденовируса иммуногенными эпитопами белка circumsporozoite плазмодия

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US (1) US20170348405A1 (enExample)
EP (2) EP3412306A3 (enExample)
JP (2) JP5947719B2 (enExample)
KR (1) KR20120094469A (enExample)
CN (2) CN105770880A (enExample)
BR (1) BR112012003808A2 (enExample)
CA (1) CA2769415A1 (enExample)
IL (1) IL217709A (enExample)
MX (1) MX339830B (enExample)
NZ (1) NZ598703A (enExample)
PH (1) PH12012500164A1 (enExample)
RU (1) RU2585228C2 (enExample)
SG (2) SG178476A1 (enExample)
UA (1) UA108081C2 (enExample)
WO (2) WO2011022002A1 (enExample)
ZA (1) ZA201201286B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012154199A1 (en) 2010-10-18 2012-11-15 The Government Of The United States, As Represented By The Secretary Of The Army Soluble recombinant plasmodium falciparum circumsporozoite protein
US20120244178A1 (en) * 2011-03-25 2012-09-27 Denise Doolan Plasmodium falciparum antigens
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
SG11201509614SA (en) * 2013-06-03 2015-12-30 Vlp Therapeutics Llc Malaria vaccine
ES2899913T3 (es) 2014-09-24 2022-03-15 Salk Inst For Biological Studi Virus tumorales oncolíticos y métodos de uso
WO2017048689A1 (en) * 2015-09-16 2017-03-23 Artificial Cell Technologies, Inc. Anti-malaria compositions and methods
US10517938B2 (en) 2016-01-21 2019-12-31 Janssen Vaccines & Prevention B.V. Adenovirus based malaria vaccine encoding and displaying a malaria antigen
EP3390645B1 (en) 2016-02-23 2022-09-14 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CN107841513B (zh) * 2016-09-18 2023-04-14 中国科学院上海巴斯德研究所 基于M2e表位的广谱型流感疫苗
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
CN108192876A (zh) * 2017-12-07 2018-06-22 东莞市第八人民医院 一种人3型腺病毒衣壳蛋白同时展示ca16双中和抗原表位疫苗候选株的制备方法和应用
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
WO2020221451A1 (en) * 2019-04-30 2020-11-05 Humabs Biomed Sa Antibodies binding to plasmodium circumsporozoite protein and uses thereof
CN110687289B (zh) * 2019-10-17 2023-04-18 中国人民解放军陆军军医大学 Fgl2蛋白作为疟疾感染标志物的应用
GB201915905D0 (en) * 2019-11-01 2019-12-18 Spybiotech Ltd Viruses with modified capsid proteins
JP2021178021A (ja) * 2020-05-14 2021-11-18 株式会社三洋物産 遊技機
US20240240203A1 (en) * 2021-05-04 2024-07-18 SpyBiotech Limited Adenoviral vectors and vaccines thereof
CA3233100A1 (en) * 2021-09-23 2023-03-30 Sagittarius Bio, Inc. Adenoviruses and methods for using adenoviruses
CN120944926B (zh) * 2025-10-15 2026-01-30 华中科技大学同济医学院附属同济医院 衣壳表面展示超大片段抗原的重组腺病毒、构建方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008140474A1 (en) * 2006-10-26 2008-11-20 Johns Hopkins University Recombinant adenovirus vaccines
RU2356577C9 (ru) * 2002-10-23 2009-08-10 Глаксосмитклайн Байолоджикалс С.А. Способы вакцинации против малярии

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066623A (en) * 1993-11-23 2000-05-23 The United States Of America As Represented By The Secretary Of The Navy Polynucleotide vaccine protective against malaria, methods of protection and vector for delivering polynucleotide vaccines
AU2002327338A1 (en) * 2001-07-25 2003-02-17 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
EP1573012B1 (en) * 2002-12-17 2011-11-30 Crucell Holland B.V. Recombinant viral-based malaria vaccines
CA2524499A1 (en) * 2003-05-14 2004-11-25 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Broadening adenovirus tropism
JP2005287309A (ja) * 2004-03-31 2005-10-20 Dnavec Research Inc 遺伝子導入を増強するための薬剤および方法
CN101072879B (zh) * 2004-10-13 2011-05-11 克鲁塞尔荷兰公司 改良的腺病毒载体及其应用
US8765146B2 (en) * 2005-08-31 2014-07-01 Genvec, Inc. Adenoviral vector-based malaria vaccines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2356577C9 (ru) * 2002-10-23 2009-08-10 Глаксосмитклайн Байолоджикалс С.А. Способы вакцинации против малярии
WO2008140474A1 (en) * 2006-10-26 2008-11-20 Johns Hopkins University Recombinant adenovirus vaccines

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Publication number Publication date
CA2769415A1 (en) 2011-02-24
CN103025349A (zh) 2013-04-03
SG10201404970PA (en) 2014-10-30
CN103025349B (zh) 2016-05-18
WO2011022002A1 (en) 2011-02-24
ZA201201286B (en) 2013-05-29
JP2013502221A (ja) 2013-01-24
HK1179508A1 (zh) 2013-10-04
UA108081C2 (uk) 2015-03-25
MX2012002131A (es) 2012-04-11
EP2467157A4 (en) 2014-01-22
IL217709A (en) 2016-05-31
PH12012500164A1 (en) 2022-03-09
SG178476A1 (en) 2012-03-29
IL217709A0 (en) 2012-03-29
AU2010286187A1 (en) 2012-02-16
EP3412306A2 (en) 2018-12-12
JP5947719B2 (ja) 2016-07-06
EP2467157A1 (en) 2012-06-27
RU2012110255A (ru) 2013-09-27
JP6293181B2 (ja) 2018-03-14
MX339830B (es) 2016-06-13
CN105770880A (zh) 2016-07-20
NZ598703A (en) 2014-04-30
JP2016146837A (ja) 2016-08-18
EP3412306A3 (en) 2019-01-02
BR112012003808A2 (pt) 2016-11-16
WO2011022522A1 (en) 2011-02-24
KR20120094469A (ko) 2012-08-24
US20170348405A1 (en) 2017-12-07

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