JP2019500320A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019500320A5 JP2019500320A5 JP2018522569A JP2018522569A JP2019500320A5 JP 2019500320 A5 JP2019500320 A5 JP 2019500320A5 JP 2018522569 A JP2018522569 A JP 2018522569A JP 2018522569 A JP2018522569 A JP 2018522569A JP 2019500320 A5 JP2019500320 A5 JP 2019500320A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- rsv
- protein
- virus
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 27
- 230000002163 immunogen Effects 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 26
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 241000700605 Viruses Species 0.000 claims description 8
- 210000003501 vero cell Anatomy 0.000 claims description 8
- 239000002671 adjuvant Substances 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000002238 attenuated effect Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 229940087168 alpha tocopherol Drugs 0.000 claims description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 2
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 229960000984 tocofersolan Drugs 0.000 claims description 2
- 239000002076 α-tocopherol Substances 0.000 claims description 2
- 235000004835 α-tocopherol Nutrition 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 description 3
- 241000144282 Sigmodon Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 241000144290 Sigmodon hispidus Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023065428A JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562247962P | 2015-10-29 | 2015-10-29 | |
| US62/247,962 | 2015-10-29 | ||
| US201662334547P | 2016-05-11 | 2016-05-11 | |
| US62/334,547 | 2016-05-11 | ||
| PCT/US2016/058976 WO2017075125A1 (en) | 2015-10-29 | 2016-10-27 | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023065428A Division JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500320A JP2019500320A (ja) | 2019-01-10 |
| JP2019500320A5 true JP2019500320A5 (enExample) | 2019-12-05 |
| JP7311872B2 JP7311872B2 (ja) | 2023-07-20 |
Family
ID=58630734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522569A Active JP7311872B2 (ja) | 2015-10-29 | 2016-10-27 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
| JP2023065428A Pending JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023065428A Pending JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11235050B2 (enExample) |
| EP (1) | EP3368547A4 (enExample) |
| JP (2) | JP7311872B2 (enExample) |
| KR (1) | KR20180085730A (enExample) |
| CN (1) | CN108602858A (enExample) |
| BR (1) | BR112018008708A2 (enExample) |
| CA (1) | CA3003726A1 (enExample) |
| MX (1) | MX2018005462A (enExample) |
| SG (1) | SG11201803581VA (enExample) |
| WO (1) | WO2017075125A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014152534A1 (en) | 2013-03-14 | 2014-09-25 | Emory University | Recombinant rsv with silent mutations, vaccines, and methods related thereto |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| SMT202100106T1 (it) | 2016-04-05 | 2021-03-15 | Janssen Vaccines & Prevention Bv | Proteina f di rsv pre-fusione solubile stabilizzata per uso nella profilassi di infezione da rsv |
| CN115947873A (zh) | 2017-04-04 | 2023-04-11 | 华盛顿大学 | 显示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
| EP3758747A1 (en) | 2018-02-28 | 2021-01-06 | University of Washington | Self-asssembling nanostructure vaccines |
| BR112021008975A2 (pt) * | 2018-11-13 | 2021-08-17 | Janssen Vaccines & Prevention B.V. | proteínas f do rsv pré-fusão estabilizadas |
| US12304929B2 (en) * | 2021-04-12 | 2025-05-20 | Sk Bioscience Co., Ltd. | Recombinant RSV live vaccine strain and the preparing method thereof |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
| AT401526B (de) | 1993-02-10 | 1996-09-25 | Scheirer Winfried | Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung |
| DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
| US7465574B2 (en) | 1994-09-30 | 2008-12-16 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
| US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
| JPH11512609A (ja) | 1995-09-27 | 1999-11-02 | アメリカ合衆国 | クローン化されたヌクレオチド配列からの感染性ＲＳウイルス（ｒｅｓｐｉｒａｔｏｒｙ ｓｙｎｃｙｔｉａｌ ｖｉｒｕｓ）の生産 |
| US6713066B1 (en) | 1996-07-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
| US7846455B2 (en) | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
| US6923971B2 (en) | 1995-09-27 | 2005-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
| US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
| US6214805B1 (en) | 1996-02-15 | 2001-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | RNase L activators and antisense oligonucleotides effective to treat RSV infections |
| KR100894670B1 (ko) | 1996-07-15 | 2009-04-22 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클론닝된 뉴클레오타이드 서열로부터 약독화된 호흡기 세포융합 바이러스 백신의 생산 |
| US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| US6074859A (en) | 1997-07-08 | 2000-06-13 | Kikkoman Corporation | Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein |
| US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
| AU2001263443A1 (en) * | 2000-05-25 | 2001-12-03 | Med Immune, Inc. | F-protein epitope-based vaccine for respiratory syncytial virus infection |
| JP4783726B2 (ja) | 2003-03-28 | 2011-09-28 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスサブグループｂ株９３２０に関連する組成物および方法 |
| AU2004303719B2 (en) | 2003-12-24 | 2010-11-11 | Intravacc B.V. | A respiratory syncytial virus with a genomic deficiency complemented in trans |
| WO2006042156A2 (en) | 2004-10-08 | 2006-04-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS represneted by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION | Modulation of replicative fitness by using less frequently used synonymous codons |
| US7951384B2 (en) | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EP2099486A2 (en) | 2006-11-30 | 2009-09-16 | Government Of The United States Of America, As Represented by the Secretary | Codon modified immunogenic compositions and methods of use |
| KR101621100B1 (ko) | 2007-03-30 | 2016-05-13 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 백신에 유용한 약독화 바이러스 |
| US8580270B2 (en) | 2008-09-30 | 2013-11-12 | University Of Massachusetts | Respiratory synctial virus (RSV) sequences for protein expression and vaccines |
| CA2742086A1 (en) | 2008-11-05 | 2010-05-14 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
| PT3067064T (pt) | 2008-12-09 | 2020-06-16 | Novavax Inc | Proteínas f vsr modificadas e processos para a sua utilização |
| WO2011008974A2 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| US20110097358A1 (en) | 2009-10-12 | 2011-04-28 | Techno Vax, Inc. | RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs) |
| US10227569B2 (en) | 2011-04-12 | 2019-03-12 | Emory University | Respiratory syncytial virus expression vectors |
| PL3275892T3 (pl) * | 2011-05-13 | 2020-09-07 | Glaxosmithkline Biologicals S.A. | Przedfuzyjne antygeny RSV F |
| JP2014520805A (ja) | 2011-07-06 | 2014-08-25 | ナノバイオ コーポレーション | ヒト呼吸器合胞体ウイルスワクチン |
| US8816081B2 (en) | 2012-08-06 | 2014-08-26 | Basf Se | Boron containing perylene monoimides, a process for their production, their use as building blocks for the production of perylene monoimide derivatives, monoimide derivatives and their use in dye-sensitized solar cells |
| PL2954049T3 (pl) | 2013-02-08 | 2023-10-16 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Atenuacja ludzkiego syncytialnego wirusa oddechowego przez deoptymalizację par kodonów w skali genomu |
| PL2970398T3 (pl) | 2013-03-13 | 2024-09-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Białka f rsv przed fuzją i ich zastosowanie |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| US9060975B2 (en) * | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| WO2014152534A1 (en) | 2013-03-14 | 2014-09-25 | Emory University | Recombinant rsv with silent mutations, vaccines, and methods related thereto |
-
2016
- 2016-10-27 EP EP16860742.2A patent/EP3368547A4/en not_active Withdrawn
- 2016-10-27 US US15/772,275 patent/US11235050B2/en active Active
- 2016-10-27 MX MX2018005462A patent/MX2018005462A/es unknown
- 2016-10-27 WO PCT/US2016/058976 patent/WO2017075125A1/en not_active Ceased
- 2016-10-27 KR KR1020187014777A patent/KR20180085730A/ko not_active Ceased
- 2016-10-27 BR BR112018008708-4A patent/BR112018008708A2/en not_active Application Discontinuation
- 2016-10-27 JP JP2018522569A patent/JP7311872B2/ja active Active
- 2016-10-27 CN CN201680072681.XA patent/CN108602858A/zh active Pending
- 2016-10-27 SG SG11201803581VA patent/SG11201803581VA/en unknown
- 2016-10-27 CA CA3003726A patent/CA3003726A1/en active Pending
-
2022
- 2022-01-14 US US17/575,829 patent/US12257296B2/en active Active
-
2023
- 2023-04-13 JP JP2023065428A patent/JP2023100654A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019500320A5 (enExample) | ||
| Lee et al. | Mechanisms of cross-protection by influenza virus M2-based vaccines | |
| US11389523B2 (en) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein | |
| JP2017503482A5 (enExample) | ||
| HRP20171213T1 (hr) | Glikoproteinske čestice nalik virusu (vlp) bjesnoće | |
| JP6990814B2 (ja) | アヒル腸炎ウイルス及びその使用 | |
| US7244435B2 (en) | DNA vaccine expressing HA1 of equine-2 influenza virus | |
| CN108368488B (zh) | 鸭肠炎病毒及其用途 | |
| Wang et al. | Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV | |
| US20230310581A1 (en) | A live attenuated measles virus vectored vaccine for sars-cov-2 | |
| CN104293741A (zh) | 一种呼吸道合胞病毒病毒样颗粒疫苗及其制备方法和应用 | |
| JP2021500876A (ja) | 複数の異種抗原をコードする組換え非病原性マレック病ウイルス構築物 | |
| JP5675789B2 (ja) | 免疫接種のための発現ベクターとしての水疱性口内炎ウイルスの異なる複数の抗原型 | |
| WO2020215350A1 (zh) | 禽流感与禽腺病毒4型二联基因工程亚单位疫苗及其制备方法 | |
| CN104031889A (zh) | 表达传染性法氏囊病毒vp2蛋白的重组火鸡疱疹病毒疫苗及应用 | |
| Ying et al. | Construction and immunological characterization of CD40L or GM-CSF incorporated Hantaan virus like particle | |
| WO2005054451A1 (ja) | 高度安全性痘瘡ワクチンウイルスおよびワクシニアウイルスベクター | |
| CN107344969B (zh) | 一种纳米流感疫苗及构建方法和应用 | |
| CN104353070B (zh) | 一种鸡传染性支气管炎病毒的基因工程亚单位疫苗及其制备方法 | |
| Di et al. | The self-assembled nanoparticle-based multi-epitope influenza mRNA vaccine elicits protective immunity against H1N1 and B influenza viruses in mice | |
| CN113430178B (zh) | 一种表达ii型单纯疱疹病毒蛋白的重组流感病毒株及其制备方法与应用 | |
| CN103316357B (zh) | 携带rsv基因的重组流感病毒嵌合疫苗及其制备方法 | |
| Allam et al. | Perspective vaccines for emerging viral diseases in farm animals | |
| Mu et al. | Protection against influenza A virus by vaccination with a recombinant fusion protein linking influenza M2e to human serum albumin (HSA) | |
| CN102603898B (zh) | 与i群禽腺病毒免疫相关融合蛋白及其编码基因与应用 |