JOP20210106A1 - بروتينات rsv f سابقة الاندماج مستقرة - Google Patents

بروتينات rsv f سابقة الاندماج مستقرة

Info

Publication number
JOP20210106A1
JOP20210106A1 JOP/2021/0106A JOP20210106A JOP20210106A1 JO P20210106 A1 JOP20210106 A1 JO P20210106A1 JO P20210106 A JOP20210106 A JO P20210106A JO P20210106 A1 JOP20210106 A1 JO P20210106A1
Authority
JO
Jordan
Prior art keywords
proteins
fusion rsv
stabilized pre
rsv
stabilized
Prior art date
Application number
JOP/2021/0106A
Other languages
English (en)
Inventor
Johannes Petrus Maria Langedijk
Original Assignee
Janssen Vaccines And Prevention B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Vaccines And Prevention B V filed Critical Janssen Vaccines And Prevention B V
Publication of JOP20210106A1 publication Critical patent/JOP20210106A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

يوفر الاختراع الحالي بروتينات F لفيروس مخلوي تنفسي (RSV) سابقة للاندماج مستقرة، تركيبات مناعية تشتمل على تلك البروتينات واستخداماتها للوقاية من و/أو علاج إصابة بعدوى RSV.
JOP/2021/0106A 2018-11-13 2019-11-12 بروتينات rsv f سابقة الاندماج مستقرة JOP20210106A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18205863 2018-11-13
PCT/EP2019/080989 WO2020099383A1 (en) 2018-11-13 2019-11-12 Stabilized pre-fusion rsv f proteins

Publications (1)

Publication Number Publication Date
JOP20210106A1 true JOP20210106A1 (ar) 2023-01-30

Family

ID=64308587

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0106A JOP20210106A1 (ar) 2018-11-13 2019-11-12 بروتينات rsv f سابقة الاندماج مستقرة

Country Status (19)

Country Link
US (1) US20220017574A1 (ar)
EP (1) EP3880243A1 (ar)
JP (1) JP2022513025A (ar)
KR (1) KR20210091749A (ar)
CN (1) CN113164583A (ar)
AU (1) AU2019377989A1 (ar)
BR (1) BR112021008975A2 (ar)
CA (1) CA3117275A1 (ar)
CL (1) CL2021001212A1 (ar)
CO (1) CO2021006308A2 (ar)
CR (1) CR20210306A (ar)
EA (1) EA202191355A1 (ar)
EC (1) ECSP21042554A (ar)
IL (1) IL282892A (ar)
JO (1) JOP20210106A1 (ar)
MX (1) MX2021005607A (ar)
PE (1) PE20211469A1 (ar)
SG (1) SG11202104522UA (ar)
WO (1) WO2020099383A1 (ar)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3821906A1 (en) 2015-07-07 2021-05-19 Janssen Vaccines & Prevention B.V. Vaccine against rsv comprising modified f polypeptide
IL262109B2 (en) 2016-04-05 2023-04-01 Janssen Vaccines Prevention B V vaccine against rsv
MY194419A (en) 2016-05-30 2022-11-30 Janssen Vaccines & Prevention Bv Stabilized pre-fusion rsv f proteins
WO2022175477A1 (en) * 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv fb antigens
KR20230047033A (ko) * 2021-09-29 2023-04-06 에스케이바이오사이언스(주) 재조합된 약독화 rsv 생백신 및 이를 제조하는 방법
CN115850396B (zh) * 2022-12-22 2024-02-06 北京吉诺卫生物科技有限公司 一种rsv纳米颗粒疫苗及其制备方法与应用
WO2024175579A1 (en) 2023-02-21 2024-08-29 Janssen Vaccines & Prevention B.V. Stabilized trimeric rsv fusion proteins without a heterologous trimerzation domain
CN117304279B (zh) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 一种重组rsv f蛋白及其应用
CN117304280B (zh) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 一种重组rsv f蛋白及其应用
CN117777251B (zh) * 2024-02-27 2024-06-04 普大生物科技(泰州)有限公司 一种rsv纳米颗粒疫苗及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
IL61904A (en) 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
EP0173552B1 (en) 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
SE0202110D0 (sv) 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
SE0301998D0 (sv) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
US20100261155A1 (en) * 2007-06-06 2010-10-14 Nationwide Children's Hospital, Inc. Methods and compositions relating to viral fusion proteins
ES2597439T3 (es) 2007-12-24 2017-01-18 Id Biomedical Corporation Of Quebec Antígenos recombinantes del VSR
MA33449B1 (ar) 2009-06-24 2012-07-03 Glaxosmithkline Biolog Sa مولدات ضد مؤتلفة vrs
CA2766205A1 (en) 2009-06-24 2010-12-29 Id Biomedical Corporation Of Quebec Vaccine comprising at least two paramyxovirus f protein antigens
EP2464664B1 (en) * 2009-08-13 2015-09-23 Crucell Holland B.V. Antibodies against human respiratory syncytial virus (rsv) and methods of use
NZ703035A (en) * 2010-07-09 2016-06-24 Crucell Holland Bv Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
JP2014519819A (ja) 2011-05-13 2014-08-21 ノバルティス アーゲー 融合前ｒｓｖｆ抗原
US10017543B2 (en) * 2013-03-13 2018-07-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
US10232032B2 (en) * 2013-03-14 2019-03-19 Emory University Recombinant RSV with silent mutations, vaccines, and methods related thereto
EA035522B1 (ru) * 2013-04-25 2020-06-29 Янссен Вэксинс Энд Превеншн Б.В. Стабильные растворимые f-полипептиды rsv в конформации "до слияния"
CN105408348B (zh) * 2013-06-17 2021-07-06 扬森疫苗与预防公司 稳定化的可溶性融合前rsv f多肽
WO2016040556A1 (en) * 2014-09-12 2016-03-17 Rsv Corporation Virosomes containing respiratory syncytial virus strain line 19 fusion protein and uses thereof
US10457708B2 (en) * 2015-07-07 2019-10-29 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F polypeptides
EP3821906A1 (en) 2015-07-07 2021-05-19 Janssen Vaccines & Prevention B.V. Vaccine against rsv comprising modified f polypeptide
BR112018008708A2 (pt) * 2015-10-29 2018-11-06 Univ Emory rsv quimérico, composições imunogênicas e métodos de uso
AU2016379097C1 (en) * 2015-12-23 2021-04-08 Pfizer Inc. RSV F protein mutants
EP3436064A1 (en) * 2016-03-29 2019-02-06 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Substitutions-modified prefusion rsv f proteins and their use
PE20190420A1 (es) 2016-04-05 2019-03-19 Janssen Vaccines And Prevention B V Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas
MY194419A (en) * 2016-05-30 2022-11-30 Janssen Vaccines & Prevention Bv Stabilized pre-fusion rsv f proteins

Also Published As

Publication number Publication date
US20220017574A1 (en) 2022-01-20
AU2019377989A1 (en) 2023-10-05
JP2022513025A (ja) 2022-02-07
EP3880243A1 (en) 2021-09-22
ECSP21042554A (es) 2021-11-30
CN113164583A (zh) 2021-07-23
EA202191355A1 (ru) 2021-09-20
CO2021006308A2 (es) 2021-05-31
IL282892A (en) 2021-06-30
KR20210091749A (ko) 2021-07-22
BR112021008975A2 (pt) 2021-08-17
MX2021005607A (es) 2021-06-30
SG11202104522UA (en) 2021-05-28
CA3117275A1 (en) 2020-05-22
WO2020099383A1 (en) 2020-05-22
CR20210306A (es) 2021-07-22
PE20211469A1 (es) 2021-08-05
CL2021001212A1 (es) 2021-10-22

Similar Documents

Publication Publication Date Title
MX2021005607A (es) Proteinas f de prefusion del vrs estabilizadas.
MX2022015257A (es) Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas.
MY201791A (en) Stabilized soluble pre-fusion rsv f polypeptides
PH12018502332A1 (en) Stabilized pre-fusion rsv f proteins
PH12015502735B1 (en) Stabilized soluble pre-fusion rsv f polypeptides
EA201890235A1 (ru) Стабилизированные растворимые f-полипептиды rsv до слияния
EA201070794A1 (ru) Рекомбинантные антигены rsv
PH12017501534A1 (en) Antiviral compounds
GEP20227374B (en) Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
PH12020550051A1 (en) Glp-1 compositions and uses thereof
MX2012000035A (es) Antigenos de virus de sincicio respiratorio recombinantes.
MX2021013111A (es) Una vacuna de subunidad para el tratamiento o la prevencion de una infeccion del tracto respiratorio.
MX2021004356A (es) Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas.
MX2021006138A (es) Otros compuestos heteroaromaticos que tienen actividad contra el vrs.
MX2023009738A (es) Antigenos de rsv fb prefusion estabilizados.
TR201905336T4 (tr) Rekombinant rsv antijenleri.