CA2587084C - Modulation of replicative fitness by using less frequently used synonym ous codons - Google Patents

Modulation of replicative fitness by using less frequently used synonym ous codons Download PDF

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Publication number
CA2587084C
CA2587084C CA2587084A CA2587084A CA2587084C CA 2587084 C CA2587084 C CA 2587084C CA 2587084 A CA2587084 A CA 2587084A CA 2587084 A CA2587084 A CA 2587084A CA 2587084 C CA2587084 C CA 2587084C
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CA
Canada
Prior art keywords
deoptimized
codons
coding sequence
virus
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2587084A
Other languages
French (fr)
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CA2587084A1 (en
Inventor
Olen M. Kew
Cara C. Burns
Jing Shaw
Raymond Campagnoli
Jacqueline Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centers of Disease Control and Prevention (Department of Health and Human Services)
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Centers of Disease Control and Prevention (Department of Health and Human Services)
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Publication date
Priority to US61754504P priority Critical
Priority to US60/617,545 priority
Application filed by Centers of Disease Control and Prevention (Department of Health and Human Services) filed Critical Centers of Disease Control and Prevention (Department of Health and Human Services)
Priority to PCT/US2005/036241 priority patent/WO2006042156A2/en
Publication of CA2587084A1 publication Critical patent/CA2587084A1/en
Application granted granted Critical
Publication of CA2587084C publication Critical patent/CA2587084C/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

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