JP2018537087A5 - - Google Patents
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- JP2018537087A5 JP2018537087A5 JP2018524747A JP2018524747A JP2018537087A5 JP 2018537087 A5 JP2018537087 A5 JP 2018537087A5 JP 2018524747 A JP2018524747 A JP 2018524747A JP 2018524747 A JP2018524747 A JP 2018524747A JP 2018537087 A5 JP2018537087 A5 JP 2018537087A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- nucleotide sequence
- factor viii
- aav
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255317P | 2015-11-13 | 2015-11-13 | |
| US62/255,317 | 2015-11-13 | ||
| PCT/US2016/061684 WO2017083762A1 (en) | 2015-11-13 | 2016-11-11 | Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020132079A Division JP7069258B2 (ja) | 2015-11-13 | 2020-08-04 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537087A JP2018537087A (ja) | 2018-12-20 |
| JP2018537087A5 true JP2018537087A5 (enExample) | 2019-12-12 |
| JP6768798B2 JP6768798B2 (ja) | 2020-10-14 |
Family
ID=57539605
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524747A Active JP6768798B2 (ja) | 2015-11-13 | 2016-11-11 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
| JP2020132079A Active JP7069258B2 (ja) | 2015-11-13 | 2020-08-04 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
| JP2022075864A Active JP7307836B2 (ja) | 2015-11-13 | 2022-05-02 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
| JP2023108132A Active JP7631425B2 (ja) | 2015-11-13 | 2023-06-30 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020132079A Active JP7069258B2 (ja) | 2015-11-13 | 2020-08-04 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
| JP2022075864A Active JP7307836B2 (ja) | 2015-11-13 | 2022-05-02 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
| JP2023108132A Active JP7631425B2 (ja) | 2015-11-13 | 2023-06-30 | 組換えｆｖｉｉｉ変異型をコードする血友病ａ遺伝子治療用高発現ウイルスベクター |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US10189888B2 (enExample) |
| EP (1) | EP3374387A1 (enExample) |
| JP (4) | JP6768798B2 (enExample) |
| KR (2) | KR102484553B1 (enExample) |
| CN (3) | CN116479001A (enExample) |
| AU (4) | AU2016353353B2 (enExample) |
| BR (1) | BR112018009717B1 (enExample) |
| CA (1) | CA3005334A1 (enExample) |
| CL (1) | CL2018001299A1 (enExample) |
| CO (1) | CO2018005377A2 (enExample) |
| EA (2) | EA038288B1 (enExample) |
| IL (3) | IL305526A (enExample) |
| MX (1) | MX2018005982A (enExample) |
| MY (2) | MY198589A (enExample) |
| SG (2) | SG11201804070XA (enExample) |
| TW (3) | TWI777175B (enExample) |
| WO (1) | WO2017083762A1 (enExample) |
| ZA (3) | ZA201803443B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115141836B (zh) | 2015-10-28 | 2024-08-27 | 桑格摩生物治疗股份有限公司 | 肝特异性构建体、因子viii表达盒及其使用方法 |
| TWI823830B (zh) | 2015-11-13 | 2023-12-01 | 日商武田藥品工業股份有限公司 | 用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體 |
| CN116479001A (zh) | 2015-11-13 | 2023-07-25 | 武田药品工业株式会社 | 用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体 |
| US11191847B2 (en) | 2016-04-15 | 2021-12-07 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating hemophilia B |
| EP3452102B9 (en) * | 2016-04-15 | 2024-09-04 | The Trustees of The University of Pennsylvania | Gene therapy for treating hemophilia a |
| PT3534922T (pt) | 2016-11-04 | 2024-06-07 | Takeda Pharmaceuticals Co | Formulações de vírus adenoassociado |
| CN111372612A (zh) * | 2017-09-27 | 2020-07-03 | 西吉隆医疗股份有限公司 | 包含活性细胞的方法、组合物和可植入元件 |
| EP3668997A4 (en) * | 2017-10-02 | 2021-05-19 | Research Institute at Nationwide Children's Hospital | SYSTEM FOR MIRNA DETARGETING FOR TISSUE-SPECIFIC INTERFERENCE |
| KR102105145B1 (ko) * | 2017-10-13 | 2020-05-13 | 영남대학교 산학협력단 | 촬영 장치 및 용기 |
| KR101952102B1 (ko) * | 2017-12-07 | 2019-02-26 | 주식회사 지앤피바이오사이언스 | 단백질 발현량이 증대된 인자 ⅷ 변이체 발현벡터 |
| KR20210034013A (ko) * | 2018-07-16 | 2021-03-29 | 박스알타 인코퍼레이티드 | 발현이 증가된 재조합 fviii 변이체들을 인코딩하는 바이러스 벡터를 이용한 혈우병의 유전적 치료법 |
| EP3829650A4 (en) * | 2018-08-03 | 2022-05-04 | Sangamo Therapeutics, Inc. | IMPROVED CLINICAL PARAMETERS BY EXPRESSION OF FACTOR VIII |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| TWI851647B (zh) * | 2019-01-16 | 2024-08-11 | 日商武田藥品工業股份有限公司 | 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體 |
| EP3923992A1 (en) | 2019-02-15 | 2021-12-22 | CRISPR Therapeutics AG | Gene editing for hemophilia a with improved factor viii expression |
| CN113710284A (zh) * | 2019-06-05 | 2021-11-26 | 克里斯珀医疗股份公司 | 具有改善的因子viii表达的血友病a基因编辑 |
| EP3986481A2 (en) * | 2019-06-20 | 2022-04-27 | Takeda Pharmaceutical Company Limited | Method of treatment with viral-based gene therapy |
| WO2021084276A2 (en) * | 2019-11-01 | 2021-05-06 | Freeline Therapeutics Limited | Factor viii construct |
| CN114981299A (zh) * | 2019-12-12 | 2022-08-30 | 武田药品工业株式会社 | 使用编码具有增加的表达的重组fviii变体的病毒载体的a型血友病的基因疗法 |
| KR102817222B1 (ko) * | 2021-04-02 | 2025-06-11 | 연세대학교 산학협력단 | Fe-fviii 변이 유전자로 교정된 줄기세포, 이로부터 분화된 내피 세포 및 이를 포함하는 혈우병 예방 또는 치료용 약제학적 조성물 |
| KR102421131B1 (ko) * | 2021-05-28 | 2022-07-15 | 알엔에이진(주) | 세포내에서 장시간동안 존재할 수 있는 외부 도입 mRNA를 선별하는 방법 |
| JP2024544499A (ja) * | 2021-11-25 | 2024-12-03 | 四川至善唯新生物科技有限公司 | 遺伝子工学的改変により得られた、分泌能と凝固活性を向上させた組換えヒト第ｖｉｉｉ因子 |
| PE20251838A1 (es) * | 2022-04-28 | 2025-07-17 | Biocad Joint Stock Co | Acido nucleico de codon optimizado que codifica la proteina del factor viii de coagulacion de dominio b suprimido, y uso del mismo |
| CN115948408A (zh) * | 2022-09-23 | 2023-04-11 | 上海信致医药科技有限公司 | 改进的人凝血因子viii基因表达盒及其应用 |
| JP2026509875A (ja) | 2023-03-14 | 2026-03-25 | シギロン セラピューティクス， インコーポレイテッド | 共有結合光架橋した多糖及び島細胞を含むヒドロゲルカプセル |
| TW202517669A (zh) * | 2023-07-05 | 2025-05-01 | 日商武田藥品工業股份有限公司 | 用於Ａ型血友病之基因療法的編碼表現增加之重組ＦＶｌｌｌ變異體的病毒載體 |
| WO2025180508A1 (en) * | 2024-02-29 | 2025-09-04 | Shanghai Vitalgen Biopharma Co., Ltd. | Human factor viii variant expression cassettes and uses thereof for treating hemophilia a |
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| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| AU5772886A (en) | 1985-04-12 | 1986-11-05 | Genetics Institute Inc. | Novel procoagulant proteins |
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| US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| US5543502A (en) | 1986-06-24 | 1996-08-06 | Novo Nordisk A/S | Process for producing a coagulation active complex of factor VIII fragments |
| US6060447A (en) | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| US6346513B1 (en) | 1987-06-12 | 2002-02-12 | Baxter Trading Gmbh | Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| IE69026B1 (en) | 1987-06-12 | 1996-08-07 | Immuno Ag | Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| EP0710288B1 (en) | 1993-06-10 | 2006-04-05 | Genetic Therapy, Inc. | Adenoviral vectors for treatment of hemophilia |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US6818439B1 (en) | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
| US5952198A (en) * | 1995-05-04 | 1999-09-14 | Bayer Corporation | Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
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| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
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| US8986991B2 (en) | 2012-07-03 | 2015-03-24 | Expression Therapeutics, Llc | High yield suspension cell line, system and method for making same |
| AU2013336601B2 (en) | 2012-10-26 | 2018-01-25 | Vrije Universiteit Brussel | Vector for liver-directed gene therapy of hemophilia and methods and use thereof |
| US10398787B2 (en) | 2012-10-26 | 2019-09-03 | Vrije Universiteit Brussel | Vectors for liver-directed gene therapy of hemophilia and methods and use thereof |
| FI3889173T3 (fi) | 2013-02-15 | 2023-10-02 | Bioverativ Therapeutics Inc | Optimoitu tekijä viii:n geeni |
| JP2016518321A (ja) | 2013-03-15 | 2016-06-23 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 組み換え因子ｖｉｉｉ配合物 |
| LT3013855T (lt) * | 2013-06-24 | 2021-01-25 | Xiao, Weidong | Mutavusio viii faktoriaus kompozicijos ir metodai |
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| CN107427557B (zh) | 2014-08-13 | 2022-01-04 | 费城儿童医院 | 用于包装和表达变体因子viii以治疗血友病的改良表达组件 |
| WO2016127057A1 (en) * | 2015-02-06 | 2016-08-11 | The University Of North Carolina At Chapel Hill | Optimized human clotting factor viii gene expression cassettes and their use |
| WO2016146757A1 (en) | 2015-03-17 | 2016-09-22 | Vrije Universiteit Brussel | Optimized liver-specific expression systems for fviii and fix |
| CN116479001A (zh) | 2015-11-13 | 2023-07-25 | 武田药品工业株式会社 | 用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体 |
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2016
- 2016-11-11 CN CN202310490697.4A patent/CN116479001A/zh active Pending
- 2016-11-11 AU AU2016353353A patent/AU2016353353B2/en active Active
- 2016-11-11 CN CN201680067846.4A patent/CN108884145B/zh active Active
- 2016-11-11 CA CA3005334A patent/CA3005334A1/en active Pending
- 2016-11-11 TW TW109118505A patent/TWI777175B/zh active
- 2016-11-11 EA EA201891137A patent/EA038288B1/ru unknown
- 2016-11-11 CN CN202310964403.7A patent/CN116949052A/zh active Pending
- 2016-11-11 KR KR1020187015189A patent/KR102484553B1/ko active Active
- 2016-11-11 BR BR112018009717-9A patent/BR112018009717B1/pt active IP Right Grant
- 2016-11-11 WO PCT/US2016/061684 patent/WO2017083762A1/en not_active Ceased
- 2016-11-11 MY MYPI2020005892A patent/MY198589A/en unknown
- 2016-11-11 US US15/349,930 patent/US10189888B2/en active Active
- 2016-11-11 TW TW105136965A patent/TWI695069B/zh active
- 2016-11-11 IL IL305526A patent/IL305526A/en unknown
- 2016-11-11 EA EA202190827A patent/EA202190827A1/ru unknown
- 2016-11-11 KR KR1020227046419A patent/KR20230008256A/ko not_active Ceased
- 2016-11-11 MY MYPI2018000735A patent/MY190067A/en unknown
- 2016-11-11 SG SG11201804070XA patent/SG11201804070XA/en unknown
- 2016-11-11 IL IL281038A patent/IL281038B2/en unknown
- 2016-11-11 JP JP2018524747A patent/JP6768798B2/ja active Active
- 2016-11-11 MX MX2018005982A patent/MX2018005982A/es unknown
- 2016-11-11 TW TW111137316A patent/TW202302627A/zh unknown
- 2016-11-11 EP EP16809573.5A patent/EP3374387A1/en active Pending
- 2016-11-11 SG SG10202106307UA patent/SG10202106307UA/en unknown
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2018
- 2018-05-13 IL IL259302A patent/IL259302B/en active IP Right Grant
- 2018-05-14 CL CL2018001299A patent/CL2018001299A1/es unknown
- 2018-05-23 CO CONC2018/0005377A patent/CO2018005377A2/es unknown
- 2018-05-24 ZA ZA2018/03443A patent/ZA201803443B/en unknown
- 2018-12-05 US US16/211,202 patent/US11254731B2/en not_active Expired - Fee Related
- 2018-12-05 US US16/211,201 patent/US11492388B2/en active Active
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2019
- 2019-07-23 ZA ZA2019/04814A patent/ZA201904814B/en unknown
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2020
- 2020-06-05 AU AU2020203761A patent/AU2020203761B2/en active Active
- 2020-06-05 AU AU2020203760A patent/AU2020203760B2/en active Active
- 2020-08-04 JP JP2020132079A patent/JP7069258B2/ja active Active
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2022
- 2022-01-06 US US17/570,187 patent/US20220213172A1/en not_active Abandoned
- 2022-02-25 AU AU2022201319A patent/AU2022201319B2/en active Active
- 2022-05-02 JP JP2022075864A patent/JP7307836B2/ja active Active
- 2022-12-19 ZA ZA2022/13661A patent/ZA202213661B/en unknown
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2023
- 2023-06-30 JP JP2023108132A patent/JP7631425B2/ja active Active