JP2020518268A5 - - Google Patents
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- JP2020518268A5 JP2020518268A5 JP2019560646A JP2019560646A JP2020518268A5 JP 2020518268 A5 JP2020518268 A5 JP 2020518268A5 JP 2019560646 A JP2019560646 A JP 2019560646A JP 2019560646 A JP2019560646 A JP 2019560646A JP 2020518268 A5 JP2020518268 A5 JP 2020518268A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023027073A JP7617600B2 (ja) | 2017-05-05 | 2023-02-24 | オトフェルリンを発現させるための組成物および方法 |
| JP2024226066A JP2025063057A (ja) | 2017-05-05 | 2024-12-23 | オトフェルリンを発現させるための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762502462P | 2017-05-05 | 2017-05-05 | |
| US62/502,462 | 2017-05-05 | ||
| PCT/US2018/031009 WO2018204734A1 (en) | 2017-05-05 | 2018-05-04 | Compositions and methods for expressing otoferlin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027073A Division JP7617600B2 (ja) | 2017-05-05 | 2023-02-24 | オトフェルリンを発現させるための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020518268A JP2020518268A (ja) | 2020-06-25 |
| JP2020518268A5 true JP2020518268A5 (enExample) | 2021-07-26 |
| JP7240675B2 JP7240675B2 (ja) | 2023-03-16 |
Family
ID=64016253
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019560646A Active JP7240675B2 (ja) | 2017-05-05 | 2018-05-04 | オトフェルリンを発現させるための組成物および方法 |
| JP2023027073A Active JP7617600B2 (ja) | 2017-05-05 | 2023-02-24 | オトフェルリンを発現させるための組成物および方法 |
| JP2024226066A Pending JP2025063057A (ja) | 2017-05-05 | 2024-12-23 | オトフェルリンを発現させるための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027073A Active JP7617600B2 (ja) | 2017-05-05 | 2023-02-24 | オトフェルリンを発現させるための組成物および方法 |
| JP2024226066A Pending JP2025063057A (ja) | 2017-05-05 | 2024-12-23 | オトフェルリンを発現させるための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12359221B2 (enExample) |
| EP (1) | EP3635100A4 (enExample) |
| JP (3) | JP7240675B2 (enExample) |
| KR (2) | KR20230167138A (enExample) |
| CN (1) | CN110892062A (enExample) |
| AU (2) | AU2018261769B2 (enExample) |
| CA (1) | CA3061955A1 (enExample) |
| MX (2) | MX2019013151A (enExample) |
| WO (1) | WO2018204734A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| CN110225975A (zh) * | 2016-08-23 | 2019-09-10 | 阿库斯股份有限公司 | 用于治疗人受试者中非年龄相关的听力损害的组合物和方法 |
| CA3061955A1 (en) * | 2017-05-05 | 2018-11-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for expressing otoferlin |
| DE102018103924A1 (de) * | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| AU2019224121B2 (en) * | 2018-02-22 | 2025-08-07 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| CN119410637A (zh) | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| US12188041B2 (en) | 2018-11-01 | 2025-01-07 | University Of Florida Research Foundation, Incorporated | Codon optimized otoferlin AAV dual vector gene therapy |
| EP3911354B8 (en) * | 2019-01-18 | 2024-04-03 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| CN119320772A (zh) | 2019-02-08 | 2025-01-17 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| EP3921032A4 (en) * | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| AU2020375947A1 (en) * | 2019-10-30 | 2022-05-26 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN115066432A (zh) * | 2019-10-30 | 2022-09-16 | 分贝治疗公司 | 使用耳畸蛋白双载体系统治疗感觉神经性听力损失的组合物和方法 |
| EP4114958A1 (en) | 2020-02-21 | 2023-01-11 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| AU2021247172A1 (en) | 2020-04-01 | 2022-09-15 | University Of Florida Research Foundation, Incorporated | Dual AAV-MY07A vectors with improved safety for the treatment of USH1B |
| CN112125969A (zh) * | 2020-09-30 | 2020-12-25 | 东南大学 | 生物因子rimbp2在维持内耳毛细胞特性上的应用 |
| CN116925239B (zh) * | 2023-07-17 | 2024-10-18 | 苏州星奥拓维生物技术有限公司 | 双载体系统表达Otof基因的组合物和方法 |
| WO2025201333A1 (zh) * | 2024-03-28 | 2025-10-02 | 苏州星奥拓维生物技术有限公司 | 递送Otof基因的双载体系统和其用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4445701A (en) | 2000-03-24 | 2001-10-03 | Centre National De La Recherche Scientifique-Cnrs | Multiple human and mouse otoferlin isoforms |
| CA2553976C (en) | 2004-01-22 | 2013-09-24 | Dnavec Research Inc. | Method for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken .beta.-actin promoter |
| US8298818B2 (en) | 2006-04-28 | 2012-10-30 | University Of Florida Research Foundation, Inc. | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter |
| WO2008021290A2 (en) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Organ-specific proteins and methods of their use |
| WO2008088895A2 (en) | 2007-01-18 | 2008-07-24 | University Of Missouri-Columbia | Synthetic mini/micro-dystrophin genes to restore nnos to the sarcolemma |
| FR2919305B1 (fr) | 2007-07-26 | 2009-09-18 | Genethon Ass Loi De 1901 | Vecteurs viraux adeno-associes pour l'expression de la dysferline. |
| US8236557B2 (en) * | 2008-05-28 | 2012-08-07 | University Of Missouri-Columbia | Hybrid-AAV vectors to deliver large gene expression cassette |
| US8962314B2 (en) * | 2008-11-26 | 2015-02-24 | The Regents Of The University Of California | Lateral ventricle cell compositions and use for treating neural degenerative diseases |
| KR20190060881A (ko) * | 2010-04-23 | 2019-06-03 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 레베르 선천성 흑내장-1(lca1)의 치료를 위한 재조합 아데노-관련된 바이러스-구아닐레이트 사이클라제 조성물 및 방법 |
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| CN105209619B (zh) | 2013-03-11 | 2018-10-12 | 泰莱托恩基金会 | miR-204和miR-211及其用途 |
| ES2704677T3 (es) | 2013-04-18 | 2019-03-19 | Fond Telethon | Suministro eficaz de genes grandes por vectores de AAV duales |
| EP2999791B1 (en) | 2013-05-21 | 2018-12-05 | University of Florida Research Foundation, Inc. | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
| WO2016118787A1 (en) | 2015-01-21 | 2016-07-28 | University Of Florida Research Foundation, Inc. | Engineered receptor/ligand system for delivery of therapeutic agents |
| EP3258955A1 (en) * | 2015-02-20 | 2017-12-27 | Institut Pasteur | Prevention and/or treatment of hearing loss or impairment |
| MX2017011255A (es) * | 2015-03-03 | 2018-08-01 | Fond Telethon | Sistema de vector múltiple y sus usos. |
| CA2998491A1 (en) | 2015-09-17 | 2017-03-23 | Coda Biotherapeutics, Inc. | Compositions and methods for treating neurological disorders |
| ES2903000T3 (es) | 2015-12-11 | 2022-03-30 | Massachusetts Eye & Ear Infirmary | Materiales y métodos para administrar ácidos nucleicos a las células cocleares y vestibulares |
| JP7007273B2 (ja) | 2015-12-22 | 2022-01-24 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | 遺伝子治療用の改良された複合型二重組換えａａｖベクターシステム |
| BR112018075855A2 (pt) | 2016-06-15 | 2019-04-02 | Oxford University Innovation Limited | sistema de vetor viral adeno-associado com dupla sobreposição para a expressão abc4a |
| CN110225975A (zh) * | 2016-08-23 | 2019-09-10 | 阿库斯股份有限公司 | 用于治疗人受试者中非年龄相关的听力损害的组合物和方法 |
| US11541131B2 (en) | 2017-03-10 | 2023-01-03 | Genethon | Treatment of glycogen storage disease III |
| CA3061955A1 (en) | 2017-05-05 | 2018-11-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for expressing otoferlin |
| AU2019224121B2 (en) | 2018-02-22 | 2025-08-07 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| EP4524247A3 (en) | 2018-03-23 | 2025-06-11 | Massachusetts Eye and Ear Infirmary | Crispr/cas9-mediated exon-skipping approach for ush2a-associated usher syndrome |
| US12188041B2 (en) | 2018-11-01 | 2025-01-07 | University Of Florida Research Foundation, Incorporated | Codon optimized otoferlin AAV dual vector gene therapy |
| EP3911354B8 (en) | 2019-01-18 | 2024-04-03 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| AU2020375947A1 (en) | 2019-10-30 | 2022-05-26 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| EP4114958A1 (en) | 2020-02-21 | 2023-01-11 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| AU2021247172A1 (en) | 2020-04-01 | 2022-09-15 | University Of Florida Research Foundation, Incorporated | Dual AAV-MY07A vectors with improved safety for the treatment of USH1B |
-
2018
- 2018-05-04 CA CA3061955A patent/CA3061955A1/en active Pending
- 2018-05-04 KR KR1020237040309A patent/KR20230167138A/ko not_active Ceased
- 2018-05-04 KR KR1020197035845A patent/KR102606810B1/ko active Active
- 2018-05-04 MX MX2019013151A patent/MX2019013151A/es unknown
- 2018-05-04 CN CN201880029806.XA patent/CN110892062A/zh active Pending
- 2018-05-04 WO PCT/US2018/031009 patent/WO2018204734A1/en not_active Ceased
- 2018-05-04 AU AU2018261769A patent/AU2018261769B2/en active Active
- 2018-05-04 EP EP18793935.0A patent/EP3635100A4/en active Pending
- 2018-05-04 JP JP2019560646A patent/JP7240675B2/ja active Active
- 2018-05-04 US US16/611,049 patent/US12359221B2/en active Active
-
2019
- 2019-11-04 MX MX2023013435A patent/MX2023013435A/es unknown
-
2023
- 2023-02-24 JP JP2023027073A patent/JP7617600B2/ja active Active
-
2024
- 2024-05-09 AU AU2024203084A patent/AU2024203084A1/en active Pending
- 2024-12-23 JP JP2024226066A patent/JP2025063057A/ja active Pending
-
2025
- 2025-06-10 US US19/233,471 patent/US20250367325A1/en active Pending
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