|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
ES8801674A1
(es)
|
1985-04-12 |
1988-02-16 |
Genetics Inst |
Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US5595886A
(en)
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US5543502A
(en)
|
1986-06-24 |
1996-08-06 |
Novo Nordisk A/S |
Process for producing a coagulation active complex of factor VIII fragments
|
|
US6060447A
(en)
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
IL86693A
(en)
|
1987-06-12 |
1994-06-24 |
Stichting Centraal Lab |
Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
|
|
FR2619314B1
(fr)
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
|
EP0710288B1
(en)
|
1993-06-10 |
2006-04-05 |
Genetic Therapy, Inc. |
Adenoviral vectors for treatment of hemophilia
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
US6013516A
(en)
|
1995-10-06 |
2000-01-11 |
The Salk Institute For Biological Studies |
Vector and method of use for nucleic acid delivery to non-dividing cells
|
|
US6458563B1
(en)
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
|
US6114148C1
(en)
|
1996-09-20 |
2012-05-01 |
Gen Hospital Corp |
High level expression of proteins
|
|
US5994136A
(en)
|
1997-12-12 |
1999-11-30 |
Cell Genesys, Inc. |
Method and means for producing high titer, safe, recombinant lentivirus vectors
|
|
US6924365B1
(en)
|
1998-09-29 |
2005-08-02 |
Transkaryotic Therapies, Inc. |
Optimized messenger RNA
|
|
US6221349B1
(en)
*
|
1998-10-20 |
2001-04-24 |
Avigen, Inc. |
Adeno-associated vectors for expression of factor VIII by target cells
|
|
US6200560B1
(en)
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
CN1179976C
(zh)
*
|
2000-12-29 |
2004-12-15 |
中国科学院上海生物化学研究所 |
产生凝血因子ⅷ的生产方法和宿主细胞
|
|
ES2319745T3
(es)
|
2001-10-05 |
2009-05-12 |
Expression Therapeutics, Llc |
Secuencias de acidos nucleicos y aminoacidos que codifican polipeptidos de factor viii de alto nivel de expresion, y metodos de uso.
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
|
US7943374B2
(en)
|
2005-08-21 |
2011-05-17 |
Markus Hildinger |
Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
|
|
KR100959454B1
(ko)
|
2007-12-10 |
2010-05-25 |
주식회사 동부하이텍 |
반도체 소자 및 그 제조 방법
|
|
GB0911870D0
(en)
|
2009-07-08 |
2009-08-19 |
Ucl Business Plc |
Optimised coding sequence and promoter
|
|
US20130017997A1
(en)
*
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
|
EA038705B1
(ru)
*
|
2012-01-12 |
2021-10-07 |
Биовератив Терапьютикс Инк. |
Способы снижения иммуногенности фактора свёртывания крови viii у пациентов, получающих лечение фактором viii
|
|
JP6256882B2
(ja)
*
|
2012-02-15 |
2018-01-10 |
アムニクス オペレーティング インコーポレイテッド |
第viii因子組成物、ならびに組成物の作製方法および用途
|
|
MX367100B
(es)
|
2012-02-17 |
2019-08-05 |
The Children´S Hospital Of Philadelphia |
Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos.
|
|
CN104411338A
(zh)
*
|
2012-04-02 |
2015-03-11 |
现代治疗公司 |
用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
|
|
GB201210357D0
(en)
|
2012-06-12 |
2012-07-25 |
Ucl Business Plc |
Factor VIII sequences
|
|
US8986991B2
(en)
|
2012-07-03 |
2015-03-24 |
Expression Therapeutics, Llc |
High yield suspension cell line, system and method for making same
|
|
US10398787B2
(en)
|
2012-10-26 |
2019-09-03 |
Vrije Universiteit Brussel |
Vectors for liver-directed gene therapy of hemophilia and methods and use thereof
|
|
AU2013336601B2
(en)
|
2012-10-26 |
2018-01-25 |
Vrije Universiteit Brussel |
Vector for liver-directed gene therapy of hemophilia and methods and use thereof
|
|
WO2014127215A1
(en)
|
2013-02-15 |
2014-08-21 |
Biogen Idec Ma Inc. |
Optimized factor viii gene
|
|
EP3044231B1
(en)
*
|
2013-09-12 |
2020-08-05 |
BioMarin Pharmaceutical Inc. |
Aav vectors comprising a gene encoding factor viii
|
|
CN107427557B
(zh)
|
2014-08-13 |
2022-01-04 |
费城儿童医院 |
用于包装和表达变体因子viii以治疗血友病的改良表达组件
|
|
US11007280B2
(en)
|
2015-03-17 |
2021-05-18 |
Vrije Universiteit Brussel |
Optimized liver-specific expression systems for FVIII and FIX
|
|
CA3005565A1
(en)
*
|
2015-11-13 |
2017-05-18 |
Baxalta Incorporated |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
EA202190827A1
(ru)
|
2015-11-13 |
2021-11-30 |
Баксалта Инкорпорейтед |
Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
|