|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
JPH0788399B2
(ja)
|
1985-04-12 |
1995-09-27 |
ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド |
新規プロコアギュラント蛋白質
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US5595886A
(en)
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US5543502A
(en)
|
1986-06-24 |
1996-08-06 |
Novo Nordisk A/S |
Process for producing a coagulation active complex of factor VIII fragments
|
|
US6060447A
(en)
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
US5171844A
(en)
|
1987-06-12 |
1992-12-15 |
Gist-Brocades N.W. |
Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
FR2619314B1
(fr)
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
|
ATE322547T1
(de)
|
1993-06-10 |
2006-04-15 |
Genetic Therapy Inc |
Adenovirale vektoren für die behandlung der hämophilie
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
US6013516A
(en)
|
1995-10-06 |
2000-01-11 |
The Salk Institute For Biological Studies |
Vector and method of use for nucleic acid delivery to non-dividing cells
|
|
US6458563B1
(en)
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
|
US6114148C1
(en)
|
1996-09-20 |
2012-05-01 |
Gen Hospital Corp |
High level expression of proteins
|
|
US5994136A
(en)
|
1997-12-12 |
1999-11-30 |
Cell Genesys, Inc. |
Method and means for producing high titer, safe, recombinant lentivirus vectors
|
|
US6924365B1
(en)
|
1998-09-29 |
2005-08-02 |
Transkaryotic Therapies, Inc. |
Optimized messenger RNA
|
|
US6221349B1
(en)
*
|
1998-10-20 |
2001-04-24 |
Avigen, Inc. |
Adeno-associated vectors for expression of factor VIII by target cells
|
|
US6200560B1
(en)
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
CN1179976C
(zh)
*
|
2000-12-29 |
2004-12-15 |
中国科学院上海生物化学研究所 |
产生凝血因子ⅷ的生产方法和宿主细胞
|
|
CA2461443C
(en)
|
2001-10-05 |
2011-07-12 |
Emory University |
Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
|
|
WO2003052051A2
(en)
|
2001-12-17 |
2003-06-26 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 8 sequences
|
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
|
US7943374B2
(en)
|
2005-08-21 |
2011-05-17 |
Markus Hildinger |
Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
|
|
KR100959454B1
(ko)
|
2007-12-10 |
2010-05-25 |
주식회사 동부하이텍 |
반도체 소자 및 그 제조 방법
|
|
GB0911870D0
(en)
|
2009-07-08 |
2009-08-19 |
Ucl Business Plc |
Optimised coding sequence and promoter
|
|
US20130017997A1
(en)
*
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
|
BR112014017111A8
(pt)
*
|
2012-01-12 |
2018-05-15 |
Biogen Idec Inc |
métodos de redução de imunogenicidade contra o fator viii em indivíduos submetidos à terapia de fator viii
|
|
CN111548418A
(zh)
*
|
2012-02-15 |
2020-08-18 |
比奥贝拉蒂治疗公司 |
因子viii组合物及其制备和使用方法
|
|
WO2013123503A1
(en)
|
2012-02-17 |
2013-08-22 |
The Children's Hospital Of Philadelphia |
Aav vector compositions and methods for gene transfer to cells, organs and tissues
|
|
HK1206612A1
(en)
|
2012-04-02 |
2016-01-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of secreted proteins
|
|
GB201210357D0
(en)
|
2012-06-12 |
2012-07-25 |
Ucl Business Plc |
Factor VIII sequences
|
|
WO2014008172A2
(en)
|
2012-07-03 |
2014-01-09 |
Expression Therapeutics, Llc |
High yield suspension cell line, system and method for making same
|
|
DK2911687T3
(da)
|
2012-10-26 |
2019-05-13 |
Univ Brussel Vrije |
Vektor til levermålrettet genterapi af hæmofili og fremgangsmåder og anvendelse deraf
|
|
EP3513802B1
(en)
|
2012-10-26 |
2023-11-29 |
Vrije Universiteit Brussel |
Vector for liver-directed gene therapy of hemophilia and methods and use thereof
|
|
DK2956477T4
(da)
|
2013-02-15 |
2024-04-15 |
Bioverativ Therapeutics Inc |
Optimeret faktor viii-gen
|
|
ES2813698T3
(es)
*
|
2013-09-12 |
2021-03-24 |
Biomarin Pharm Inc |
Vectores de AAV que comprenden un gen que codifica el factor VIII
|
|
AU2015301598B2
(en)
|
2014-08-13 |
2020-07-16 |
Liron Elkouby |
An improved expression cassette for packaging and expression of variant Factor VIII for the treatment of hemostasis disorders
|
|
JP6879486B2
(ja)
|
2015-03-17 |
2021-06-02 |
フリーイェ・ユニヴェルシテイト・ブリュッセルVrije Universieit Brussel |
Fviiiおよびfix用の最適化された肝臓特異的発現系
|
|
SG11201804070XA
(en)
*
|
2015-11-13 |
2018-06-28 |
Baxalta Inc |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
EP3374388A1
(en)
*
|
2015-11-13 |
2018-09-19 |
Baxalta Incorporated |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|