TWI823830B - 用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體 - Google Patents

用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體 Download PDF

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TWI823830B
TWI823830B TW105136967A TW105136967A TWI823830B TW I823830 B TWI823830 B TW I823830B TW 105136967 A TW105136967 A TW 105136967A TW 105136967 A TW105136967 A TW 105136967A TW I823830 B TWI823830 B TW I823830B
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seq
factor viii
sequence
polynucleotide
nucleotide sequence
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TW105136967A
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TW201723180A (zh
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法科－甘特 福克諾
法蘭西斯卡 霍林
喬安斯 藍格勒
漢斯彼得 羅騰史戴納
弗利茲 許夫利格
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日商武田藥品工業股份有限公司
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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TW105136967A 2015-11-13 2016-11-11 用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體 TWI823830B (zh)

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US62/255,323 2015-11-13

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TW110136356A TWI850587B (zh) 2015-11-13 2016-11-11 用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體

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TWI851647B (zh) * 2019-01-16 2024-08-11 日商武田藥品工業股份有限公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
SG11202108357PA (en) 2019-02-15 2021-08-30 Crispr Therapeutics Ag Gene editing for hemophilia a with improved factor viii expression
CN109735547B (zh) * 2019-03-19 2022-05-31 青岛蔚蓝生物集团有限公司 一种提高毕赤酵母外源蛋白表达量的启动子及其应用
CN114375205A (zh) * 2019-06-20 2022-04-19 武田药品工业株式会社 用基于病毒的基因疗法进行治疗的方法
CN112575034B (zh) * 2019-09-29 2023-04-25 济南赛尔生物科技股份有限公司 一种治疗a型血友病的产品及应用

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KR102404550B1 (ko) * 2015-11-13 2022-05-31 다케다 야쿠힌 고교 가부시키가이샤 A형 혈우병의 유전자 요법을 위한 증가된 발현을 갖는 재조합 fviii 변이체를 인코딩하는 바이러스 벡터

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TW202229555A (zh) 2022-08-01
JP2018537089A (ja) 2018-12-20
IL259295B1 (en) 2024-06-01
JP6695426B2 (ja) 2020-05-20
KR102404550B1 (ko) 2022-05-31
US20170226188A1 (en) 2017-08-10
ZA201803442B (en) 2019-07-31
US10189889B2 (en) 2019-01-29
AU2016354550A1 (en) 2018-06-07
TW201723180A (zh) 2017-07-01
WO2017083764A1 (en) 2017-05-18
EA202092049A1 (ru) 2020-11-10
IL259295A (en) 2018-07-31
BR112018009732A8 (pt) 2019-02-26
TWI850587B (zh) 2024-08-01
CL2018001301A1 (es) 2018-12-28
EA036944B1 (ru) 2021-01-19
EP3374388A1 (en) 2018-09-19
SG11201804064WA (en) 2018-06-28
EA201891138A1 (ru) 2018-12-28
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BR112018009732A2 (en) 2018-11-21
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AU2016354550B2 (en) 2020-04-16
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IL259295B2 (en) 2024-10-01
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