JP2012532601A5 - - Google Patents
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- Publication number
- JP2012532601A5 JP2012532601A5 JP2012519119A JP2012519119A JP2012532601A5 JP 2012532601 A5 JP2012532601 A5 JP 2012532601A5 JP 2012519119 A JP2012519119 A JP 2012519119A JP 2012519119 A JP2012519119 A JP 2012519119A JP 2012532601 A5 JP2012532601 A5 JP 2012532601A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- clotting
- ctp
- coagulation
- coagulation factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 41
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 41
- 239000003114 blood coagulation factor Substances 0.000 claims 41
- 101800005309 Carboxy-terminal peptide Proteins 0.000 claims 26
- 210000004899 c-terminal region Anatomy 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 9
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 9
- 229940015047 chorionic gonadotropin Drugs 0.000 claims 9
- 102100022641 Coagulation factor IX Human genes 0.000 claims 7
- 108010076282 Factor IX Proteins 0.000 claims 7
- 229960004222 factor ix Drugs 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102100023804 Coagulation factor VII Human genes 0.000 claims 6
- 108010023321 Factor VII Proteins 0.000 claims 6
- 108010054265 Factor VIIa Proteins 0.000 claims 6
- 229940012413 factor vii Drugs 0.000 claims 6
- 229940012414 factor viia Drugs 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 102000006771 Gonadotropins Human genes 0.000 claims 4
- 108010086677 Gonadotropins Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002622 gonadotropin Substances 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22436609P | 2009-07-09 | 2009-07-09 | |
| US61/224,366 | 2009-07-09 | ||
| PCT/IL2010/000532 WO2011004361A2 (en) | 2009-07-09 | 2010-07-01 | Long-acting coagulation factors and methods of producing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015199912A Division JP6162769B2 (ja) | 2009-07-09 | 2015-10-08 | 長期作用性凝固因子およびそれを製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532601A JP2012532601A (ja) | 2012-12-20 |
| JP2012532601A5 true JP2012532601A5 (enExample) | 2013-05-16 |
| JP5823960B2 JP5823960B2 (ja) | 2015-11-25 |
Family
ID=43429620
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519119A Active JP5823960B2 (ja) | 2009-07-09 | 2010-07-01 | 長期作用性凝固因子およびそれを製造する方法 |
| JP2015199912A Active JP6162769B2 (ja) | 2009-07-09 | 2015-10-08 | 長期作用性凝固因子およびそれを製造する方法 |
| JP2017117769A Active JP6430592B2 (ja) | 2009-07-09 | 2017-06-15 | 長期作用性凝固因子およびそれを製造する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015199912A Active JP6162769B2 (ja) | 2009-07-09 | 2015-10-08 | 長期作用性凝固因子およびそれを製造する方法 |
| JP2017117769A Active JP6430592B2 (ja) | 2009-07-09 | 2017-06-15 | 長期作用性凝固因子およびそれを製造する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8476234B2 (enExample) |
| EP (2) | EP3130346A1 (enExample) |
| JP (3) | JP5823960B2 (enExample) |
| KR (3) | KR102014844B1 (enExample) |
| CN (2) | CN105153314B (enExample) |
| AU (1) | AU2010269884B2 (enExample) |
| CA (1) | CA2767503C (enExample) |
| CY (1) | CY1118733T1 (enExample) |
| DK (1) | DK2451473T3 (enExample) |
| ES (1) | ES2618209T3 (enExample) |
| HR (1) | HRP20170051T1 (enExample) |
| HU (1) | HUE032973T2 (enExample) |
| IL (2) | IL235377A (enExample) |
| LT (1) | LT2451473T (enExample) |
| MX (4) | MX346920B (enExample) |
| PL (1) | PL2451473T3 (enExample) |
| PT (1) | PT2451473T (enExample) |
| SI (1) | SI2451473T1 (enExample) |
| WO (1) | WO2011004361A2 (enExample) |
Families Citing this family (56)
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| US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
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| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
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| LT2956477T (lt) | 2013-02-15 | 2021-02-10 | Bioverativ Therapeutics Inc. | Optimizuotas faktoriaus viii genas |
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| IL320404A (en) | 2016-02-01 | 2025-06-01 | Bioverativ Therapeutics Inc | Effective Factor VIII genes |
| US11976106B2 (en) * | 2016-07-11 | 2024-05-07 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN106279436B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 活化的人凝血因子vii融合蛋白及其制备方法与用途 |
| CN106317226B (zh) * | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN110438022A (zh) * | 2018-10-10 | 2019-11-12 | 福建师范大学 | 一种前体蛋白Kex2过表达毕赤酵母菌株及其构建方法 |
| AU2020242945B2 (en) | 2019-03-19 | 2025-06-26 | CSL Innovation Pty Ltd | Factor IX variants and uses thereof in therapy |
| CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
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