JP2004533208A5 - - Google Patents
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- Publication number
- JP2004533208A5 JP2004533208A5 JP2002536324A JP2002536324A JP2004533208A5 JP 2004533208 A5 JP2004533208 A5 JP 2004533208A5 JP 2002536324 A JP2002536324 A JP 2002536324A JP 2002536324 A JP2002536324 A JP 2002536324A JP 2004533208 A5 JP2004533208 A5 JP 2004533208A5
- Authority
- JP
- Japan
- Prior art keywords
- plasmid
- seq
- polynucleotide
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013612 plasmid Substances 0.000 description 42
- 102000040430 polynucleotide Human genes 0.000 description 23
- 108091033319 polynucleotide Proteins 0.000 description 23
- 239000002157 polynucleotide Substances 0.000 description 23
- 102000039446 nucleic acids Human genes 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 21
- 150000007523 nucleic acids Chemical class 0.000 description 21
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 description 18
- 239000008194 pharmaceutical composition Substances 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 239000013600 plasmid vector Substances 0.000 description 5
- 241000701161 unidentified adenovirus Species 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- 230000005875 antibody response Effects 0.000 description 4
- 108020001507 fusion proteins Proteins 0.000 description 4
- 102000037865 fusion proteins Human genes 0.000 description 4
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 101710091045 Envelope protein Proteins 0.000 description 2
- 101710188315 Protein X Proteins 0.000 description 2
- 102100021696 Syncytin-1 Human genes 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22509700P | 2000-08-14 | 2000-08-14 | |
| US60/225,097 | 2000-08-14 | ||
| US25211500P | 2000-11-14 | 2000-11-14 | |
| US60/252,115 | 2000-11-14 | ||
| US27925701P | 2001-03-28 | 2001-03-28 | |
| US60/279,257 | 2001-03-28 | ||
| PCT/US2001/025721 WO2002032943A2 (en) | 2000-08-14 | 2001-08-14 | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533208A JP2004533208A (ja) | 2004-11-04 |
| JP2004533208A5 true JP2004533208A5 (enExample) | 2008-08-14 |
| JP5052732B2 JP5052732B2 (ja) | 2012-10-17 |
Family
ID=27397438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002536324A Expired - Fee Related JP5052732B2 (ja) | 2000-08-14 | 2001-08-14 | 遺伝的免疫化のための免疫原性を強化するＨＩＶＥｎｖ、Ｇａｇ、およびＰｏｌの改変 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7470430B2 (enExample) |
| EP (3) | EP2065468A1 (enExample) |
| JP (1) | JP5052732B2 (enExample) |
| AU (2) | AU2001284999B2 (enExample) |
| CA (1) | CA2419822C (enExample) |
| WO (1) | WO2002032943A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002032943A2 (en) | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
| CA2422882A1 (en) * | 2000-09-15 | 2002-03-21 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
| JP4601956B2 (ja) * | 2001-09-20 | 2010-12-22 | グラクソ グループ リミテッド | Ｈｉｖ−ｇａｇのコドン最適化ｄｎａワクチン |
| DE10249594A1 (de) * | 2002-10-24 | 2004-05-13 | Jassoy, Christian, Dr. | Immunisierung gegen Bestandteile des Humanen Immunschwächevirus (HIV) |
| GB0225788D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| EP1578766B1 (en) * | 2002-12-03 | 2013-02-13 | University of Massachusetts | Polyvalent, primary hiv-1 glycoprotein dna vaccines and vaccination methods |
| EP1675613B1 (en) * | 2003-09-15 | 2012-05-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Hiv vaccines based on env of multiple clades of hiv |
| GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
| CA2539864A1 (en) * | 2003-09-24 | 2005-04-07 | Oxxon Therapeutics Limited | Hiv pharmaccines |
| WO2006078279A2 (en) * | 2004-04-28 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations |
| TW200613554A (en) * | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| AU2005274948B2 (en) * | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| WO2006029338A2 (en) * | 2004-09-09 | 2006-03-16 | The Henry M. Jackson Foundation | Modified hiv-1 envelope proteins |
| ES2281252B1 (es) * | 2005-07-27 | 2009-02-16 | Consejo Superior De Investigaciones Cientificas | Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida. |
| CA2623517A1 (en) * | 2005-09-23 | 2007-04-05 | Walter Reed Army Institute Of Research (Wrair) | Antibodies with simultaneous subsite specificities to protein and lipid epitopes |
| CN101591379B (zh) * | 2008-05-27 | 2017-01-18 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于eiav减毒活疫苗的氨基酸突变而构建的抗hiv疫苗 |
| WO2011047316A1 (en) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Nucleic acid sequences encoding expandable hiv mosaic proteins |
| EP2492279A1 (en) * | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
| EP2766030A4 (en) | 2011-10-12 | 2015-09-16 | Univ Washington | MANIPULATED OUTER DOMAIN OF HV-GP120 AND MUTANTS THEREOF |
| EP2620446A1 (en) * | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| EP2698377A1 (en) * | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
| WO2014151687A2 (en) | 2013-03-15 | 2014-09-25 | University Of Massachusetts | Compositions and methods to treat aids |
| EP3126502A4 (en) * | 2014-03-31 | 2018-01-17 | Duke University | Compositions comprising ch848 envelopes and uses thereof |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| IL89567A0 (en) * | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
| DE4002636A1 (de) * | 1990-01-30 | 1991-08-01 | Boehringer Mannheim Gmbh | Expression von hiv1- und 2-polypeptiden und deren verwendung |
| EP0449116B2 (en) * | 1990-03-21 | 2004-08-25 | Geneart GmbH | DNA sequences encoding modified retroviral gag polypeptides and vaccines containing them or aggregates thereof |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| US7255862B1 (en) * | 1996-11-14 | 2007-08-14 | Connaught Technology Corporation | ALVAC/FIV constructs |
| WO1998041536A1 (en) * | 1997-03-14 | 1998-09-24 | President And Fellows Of Harvard College | Glycosylation deficient siv and hiv envelope glycoproteins |
| AUPP700798A0 (en) * | 1998-11-09 | 1998-12-03 | Australian National University, The | Recombinant viral constructs and methods relating thereto |
| EP1980617A1 (en) * | 1998-12-31 | 2008-10-15 | Novartis Vaccines and Diagnostics, Inc. | Improved expression of HIV polypeptides and production of virus-like particles |
| WO2002032943A2 (en) | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
-
2001
- 2001-08-14 WO PCT/US2001/025721 patent/WO2002032943A2/en not_active Ceased
- 2001-08-14 AU AU2001284999A patent/AU2001284999B2/en not_active Ceased
- 2001-08-14 EP EP09000424A patent/EP2065468A1/en not_active Withdrawn
- 2001-08-14 JP JP2002536324A patent/JP5052732B2/ja not_active Expired - Fee Related
- 2001-08-14 CA CA2419822A patent/CA2419822C/en not_active Expired - Lifetime
- 2001-08-14 EP EP01964108A patent/EP1311686A2/en not_active Withdrawn
- 2001-08-14 EP EP10011764A patent/EP2302059A1/en not_active Withdrawn
- 2001-08-15 AU AU8499901A patent/AU8499901A/xx active Pending
-
2003
- 2003-02-04 US US10/359,120 patent/US7470430B2/en not_active Expired - Fee Related
-
2008
- 2008-11-10 US US12/291,533 patent/US20090175910A1/en not_active Abandoned
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