CA2419822C - Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization - Google Patents
Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization Download PDFInfo
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- CA2419822C CA2419822C CA2419822A CA2419822A CA2419822C CA 2419822 C CA2419822 C CA 2419822C CA 2419822 A CA2419822 A CA 2419822A CA 2419822 A CA2419822 A CA 2419822A CA 2419822 C CA2419822 C CA 2419822C
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- C07K—PEPTIDES
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- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (7)
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| US22509700P | 2000-08-14 | 2000-08-14 | |
| US60/225,097 | 2000-08-14 | ||
| US25211500P | 2000-11-14 | 2000-11-14 | |
| US60/252,115 | 2000-11-14 | ||
| US27925701P | 2001-03-28 | 2001-03-28 | |
| US60/279,257 | 2001-03-28 | ||
| PCT/US2001/025721 WO2002032943A2 (en) | 2000-08-14 | 2001-08-14 | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
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| CA2419822A1 CA2419822A1 (en) | 2002-04-25 |
| CA2419822C true CA2419822C (en) | 2011-02-08 |
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| AU (2) | AU2001284999B2 (enExample) |
| CA (1) | CA2419822C (enExample) |
| WO (1) | WO2002032943A2 (enExample) |
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| WO2002032943A2 (en) | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
| CA2422882A1 (en) * | 2000-09-15 | 2002-03-21 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
| JP4601956B2 (ja) * | 2001-09-20 | 2010-12-22 | グラクソ グループ リミテッド | Ｈｉｖ−ｇａｇのコドン最適化ｄｎａワクチン |
| DE10249594A1 (de) * | 2002-10-24 | 2004-05-13 | Jassoy, Christian, Dr. | Immunisierung gegen Bestandteile des Humanen Immunschwächevirus (HIV) |
| GB0225788D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| EP1578766B1 (en) * | 2002-12-03 | 2013-02-13 | University of Massachusetts | Polyvalent, primary hiv-1 glycoprotein dna vaccines and vaccination methods |
| EP1675613B1 (en) * | 2003-09-15 | 2012-05-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Hiv vaccines based on env of multiple clades of hiv |
| GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
| CA2539864A1 (en) * | 2003-09-24 | 2005-04-07 | Oxxon Therapeutics Limited | Hiv pharmaccines |
| WO2006078279A2 (en) * | 2004-04-28 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations |
| TW200613554A (en) * | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| AU2005274948B2 (en) * | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| WO2006029338A2 (en) * | 2004-09-09 | 2006-03-16 | The Henry M. Jackson Foundation | Modified hiv-1 envelope proteins |
| ES2281252B1 (es) * | 2005-07-27 | 2009-02-16 | Consejo Superior De Investigaciones Cientificas | Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida. |
| CA2623517A1 (en) * | 2005-09-23 | 2007-04-05 | Walter Reed Army Institute Of Research (Wrair) | Antibodies with simultaneous subsite specificities to protein and lipid epitopes |
| CN101591379B (zh) * | 2008-05-27 | 2017-01-18 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于eiav减毒活疫苗的氨基酸突变而构建的抗hiv疫苗 |
| WO2011047316A1 (en) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Nucleic acid sequences encoding expandable hiv mosaic proteins |
| EP2492279A1 (en) * | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
| EP2766030A4 (en) | 2011-10-12 | 2015-09-16 | Univ Washington | MANIPULATED OUTER DOMAIN OF HV-GP120 AND MUTANTS THEREOF |
| EP2620446A1 (en) * | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| EP2698377A1 (en) * | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
| WO2014151687A2 (en) | 2013-03-15 | 2014-09-25 | University Of Massachusetts | Compositions and methods to treat aids |
| EP3126502A4 (en) * | 2014-03-31 | 2018-01-17 | Duke University | Compositions comprising ch848 envelopes and uses thereof |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
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| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| IL89567A0 (en) * | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
| DE4002636A1 (de) * | 1990-01-30 | 1991-08-01 | Boehringer Mannheim Gmbh | Expression von hiv1- und 2-polypeptiden und deren verwendung |
| EP0449116B2 (en) * | 1990-03-21 | 2004-08-25 | Geneart GmbH | DNA sequences encoding modified retroviral gag polypeptides and vaccines containing them or aggregates thereof |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| US7255862B1 (en) * | 1996-11-14 | 2007-08-14 | Connaught Technology Corporation | ALVAC/FIV constructs |
| WO1998041536A1 (en) * | 1997-03-14 | 1998-09-24 | President And Fellows Of Harvard College | Glycosylation deficient siv and hiv envelope glycoproteins |
| AUPP700798A0 (en) * | 1998-11-09 | 1998-12-03 | Australian National University, The | Recombinant viral constructs and methods relating thereto |
| EP1980617A1 (en) * | 1998-12-31 | 2008-10-15 | Novartis Vaccines and Diagnostics, Inc. | Improved expression of HIV polypeptides and production of virus-like particles |
| WO2002032943A2 (en) | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
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| EP1311686A2 (en) | 2003-05-21 |
| US20040033487A1 (en) | 2004-02-19 |
| US20090175910A1 (en) | 2009-07-09 |
| AU2001284999B2 (en) | 2006-09-21 |
| CA2419822A1 (en) | 2002-04-25 |
| WO2002032943A3 (en) | 2003-01-09 |
| JP2004533208A (ja) | 2004-11-04 |
| WO2002032943A9 (en) | 2003-09-04 |
| US7470430B2 (en) | 2008-12-30 |
| JP5052732B2 (ja) | 2012-10-17 |
| EP2065468A1 (en) | 2009-06-03 |
| AU8499901A (en) | 2002-04-29 |
| WO2002032943A2 (en) | 2002-04-25 |
| EP2302059A1 (en) | 2011-03-30 |
| EP2302059A8 (en) | 2011-08-03 |
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