DE60136958D1 - Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz - Google Patents

Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz

Info

Publication number
DE60136958D1
DE60136958D1 DE60136958T DE60136958T DE60136958D1 DE 60136958 D1 DE60136958 D1 DE 60136958D1 DE 60136958 T DE60136958 T DE 60136958T DE 60136958 T DE60136958 T DE 60136958T DE 60136958 D1 DE60136958 D1 DE 60136958D1
Authority
DE
Germany
Prior art keywords
bioactive substance
preparation
producing
solid material
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136958T
Other languages
English (en)
Inventor
Yoshihiro Ohmachi
Masafumi Misaki
Shigeyuki Takada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60136958D1 publication Critical patent/DE60136958D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
DE60136958T 2000-12-01 2001-11-29 Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz Expired - Lifetime DE60136958D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000367183 2000-12-01
PCT/JP2001/010416 WO2002043709A1 (fr) 2000-12-01 2001-11-29 Procede de production d'une preparation contenant une substance bioactive

Publications (1)

Publication Number Publication Date
DE60136958D1 true DE60136958D1 (de) 2009-01-22

Family

ID=18837665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136958T Expired - Lifetime DE60136958D1 (de) 2000-12-01 2001-11-29 Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz

Country Status (8)

Country Link
US (2) US7090869B2 (de)
EP (2) EP1346722B1 (de)
JP (1) JP2009062389A (de)
AT (1) ATE416784T1 (de)
AU (1) AU2002224124A1 (de)
CA (1) CA2430934C (de)
DE (1) DE60136958D1 (de)
WO (1) WO2002043709A1 (de)

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CA2430934C (en) 2011-06-21
US20060241045A1 (en) 2006-10-26
CA2430934A1 (en) 2002-06-06
JP2009062389A (ja) 2009-03-26
EP1346722A1 (de) 2003-09-24
EP2062593A3 (de) 2011-08-17
EP1346722A4 (de) 2005-08-03
US20040018240A1 (en) 2004-01-29
US7090869B2 (en) 2006-08-15
ATE416784T1 (de) 2008-12-15
EP2062593A2 (de) 2009-05-27

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