ATE416784T1 - Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz - Google Patents

Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz

Info

Publication number
ATE416784T1
ATE416784T1 AT01998183T AT01998183T ATE416784T1 AT E416784 T1 ATE416784 T1 AT E416784T1 AT 01998183 T AT01998183 T AT 01998183T AT 01998183 T AT01998183 T AT 01998183T AT E416784 T1 ATE416784 T1 AT E416784T1
Authority
AT
Austria
Prior art keywords
bioactive substance
preparation
producing
solid material
amount
Prior art date
Application number
AT01998183T
Other languages
English (en)
Inventor
Yoshihiro Ohmachi
Masafumi Misaki
Shigeyuki Takada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE416784T1 publication Critical patent/ATE416784T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01998183T 2000-12-01 2001-11-29 Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz ATE416784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000367183 2000-12-01

Publications (1)

Publication Number Publication Date
ATE416784T1 true ATE416784T1 (de) 2008-12-15

Family

ID=18837665

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01998183T ATE416784T1 (de) 2000-12-01 2001-11-29 Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz

Country Status (8)

Country Link
US (2) US7090869B2 (de)
EP (2) EP2062593A3 (de)
JP (1) JP2009062389A (de)
AT (1) ATE416784T1 (de)
AU (1) AU2002224124A1 (de)
CA (1) CA2430934C (de)
DE (1) DE60136958D1 (de)
WO (1) WO2002043709A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10353856A1 (de) * 2003-11-18 2005-06-16 Goldschmidt Ag Emulgatorfreie Öl in Wasser-Emulsionen von Organopolysiloxanen und deren Verwendung in technischen Anwendungen
PT1586310E (pt) * 2004-04-15 2007-02-28 Helm Ag Processo para a preparação de adsorvatos de valsartan na forma de pó solto
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
NZ552093A (en) * 2004-06-17 2009-06-26 Wyeth Corp Processes for preparing gonadotropin releasing hormone receptor antagonists
JP2008503469A (ja) 2004-06-17 2008-02-07 ワイス ゴナドトロピン放出ホルモン受容体アンタゴニスト
CN101048383A (zh) * 2004-11-23 2007-10-03 惠氏公司 促性腺激素释放激素受体拮抗剂
US7538113B2 (en) * 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) * 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) * 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US7531542B2 (en) * 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) * 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
US8945598B2 (en) * 2005-12-29 2015-02-03 Cordis Corporation Low temperature drying methods for forming drug-containing polymeric compositions
US20070158880A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast tubes
US20070160672A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast films
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8304386B2 (en) * 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
WO2007092252A2 (en) 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8476234B2 (en) * 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8207236B2 (en) * 2006-05-23 2012-06-26 Ferro Corporation Method for the production of porous particles
US20080166436A1 (en) * 2007-01-10 2008-07-10 Apperon Inc. Composition for normalizing otitis externa in mammals
WO2008084504A2 (en) * 2007-01-12 2008-07-17 Rubicon Research Private Limited Pharmaceutical compositions of angiotensin ii receptor blockers
US11039707B2 (en) * 2007-05-17 2021-06-22 International Flavors & Fragrances Inc. Microencapsulated delivery system
US20090095164A1 (en) * 2007-05-17 2009-04-16 Salvatore Albert Celeste Method of enhancing beverages by means of a unique microencapsulated delivery system
WO2008156356A1 (en) * 2007-06-19 2008-12-24 Feyecon Development & Implementation B.V. Preparation of a pharmaceutically active ingredient comprising a desolventising step
EP2315571A4 (de) * 2008-07-16 2013-05-01 Surmodics Pharmaceuticals Inc Verfahren zur herstellung von mikropartikeln mit bioaktiven peptiden
GB0907251D0 (en) * 2009-04-28 2009-06-10 Univ Leiden Coplymers
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
AU2010336168A1 (en) * 2009-12-22 2012-06-14 Takeda Pharmaceutical Company Limited Sustained-release formulation
JP2012184364A (ja) * 2011-03-07 2012-09-27 Seiko Instruments Inc アクリル樹脂およびその製造方法
WO2013038399A1 (en) 2011-09-18 2013-03-21 Bio Plasmar Ltd Bio-degradable compositions and use thereof
JP6068787B2 (ja) * 2011-09-30 2017-01-25 大王製紙株式会社 ティシュペーパーの製造方法
PE20142405A1 (es) 2012-04-19 2015-01-25 Opko Biolog Ltd Variantes de oxintomodulina de accion prolongada y metodos de produccion de las mismas
EP2727584A1 (de) * 2012-10-31 2014-05-07 Takeda GmbH Abgase zur Verwendung beim Trocknen, Lagern bzw. Rekonstituieren von Biomolekülen
EP2922867B1 (de) 2012-11-20 2021-07-21 OPKO Biologics Ltd. Verfahren zur erhöhung des hydrodynamischen volumens von polypeptiden durch bindung an gonadotrophin-carboxy-terminale peptide
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
PH12017501089B1 (en) 2014-12-10 2022-06-22 Opko Biologics Ltd Methods of producing long acting ctp-modified growth hormone polypeptides
AU2016280867B2 (en) 2015-06-19 2020-02-27 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
JP2017190424A (ja) * 2016-04-15 2017-10-19 竹本油脂株式会社 ビニル共重合体
CN109071911B (zh) * 2016-04-27 2021-01-15 株式会社可乐丽 丙烯酸类热塑性树脂组合物、成型体、膜及其制造方法、以及层叠体
KR102618424B1 (ko) 2016-07-11 2023-12-26 옵코 바이오로직스 리미티드 지속성 응고 인자 vii 및 그 제조 방법
FR3068977B1 (fr) * 2017-07-12 2020-09-04 Arkema France Composition comprenant un polymere a phases multiples et un polymere (meth)acrylique, son procede de preparation et son utilisation
EP3502180A1 (de) * 2017-12-19 2019-06-26 Chi Mei Corporation Polymethacrylatzusammensetzung und daraus hergestellte optische vorrichtung sowie anzeigevorrichtung
JP7670487B2 (ja) * 2018-11-15 2025-04-30 三菱ケミカル株式会社 導電性組成物及びその製造方法と、導電体及びその製造方法
JP7391043B2 (ja) 2018-12-27 2023-12-04 株式会社カネカ 樹脂組成物およびその利用
EP3950749A4 (de) * 2019-03-28 2022-12-21 Kaneka Corporation Körniger körper und seine verwendung

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS528375B2 (de) 1973-07-02 1977-03-09
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
JPS5944308B2 (ja) 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
JPS54148722A (en) 1978-05-12 1979-11-21 Takeda Chem Ind Ltd Nonapeptide and its preparation
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
JPH0678425B2 (ja) 1984-07-06 1994-10-05 和光純薬工業株式会社 重合体の新規製造法
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
WO1987006941A1 (en) 1986-05-05 1987-11-19 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
JP2861267B2 (ja) 1989-06-01 1999-02-24 萬有製薬株式会社 生理活性物質be―18257類
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
JPH0363232A (ja) 1989-07-10 1991-03-19 Syntex Usa Inc 溶剤抽出方法
ATE122248T1 (de) * 1989-07-31 1995-05-15 Ciba Geigy Ag Extraktion organischer lösungsmittel aus geformten stoffen durch überkritische fluide und gase, nahe am kritischen punkt.
GB8919726D0 (en) 1989-08-31 1989-10-11 Fujisawa Pharmaceutical Co Ws7338 substances and preparation thereof
IL95975A (en) 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
CA2032559C (en) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
CA2073856C (en) 1990-01-24 2002-12-03 Douglas I. Buckley Glp-1 analogs useful for diabetes treatment
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5284828A (en) 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
CA2059380A1 (en) 1991-01-24 1992-07-25 Yiu-Kuen T. Lam Endothelin receptor antagonists isolated from microbispora
IL102183A (en) 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
US5312958A (en) 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
KR0154880B1 (ko) 1992-06-15 1998-10-15 피터 알.셰어러 글루카곤-유사 펩티드 및 인슐리노트로핀 유도체
US5484955A (en) 1992-07-06 1996-01-16 Takeda Chemical Industries, Ltd. Tri-higher alkyl tin azide and its use
JPH0680584A (ja) 1992-07-13 1994-03-22 Nisshin Flour Milling Co Ltd グリセンチンを有効成分とする医薬
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
NZ250844A (en) 1993-04-07 1996-03-26 Pfizer Treatment of non-insulin dependant diabetes with peptides; composition
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
AU7531094A (en) 1993-08-24 1995-03-21 Novo Nordisk A/S Protracted glp-1
JPH07101877A (ja) 1993-10-04 1995-04-18 Mitsui Toatsu Chem Inc 血小板減少症治療剤
US6280771B1 (en) * 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
CA2137206A1 (en) 1993-12-09 1995-06-10 John A. Galloway Glucagon-like insulinotropic peptides, compositions and methods
CA2178592C (en) * 1993-12-09 2009-07-28 Jurgen Engel Long-acting injection suspensions and a process for their preparation
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
PT668272E (pt) 1994-01-28 2000-10-31 Takeda Chemical Industries Ltd Processo para a producao de compostos de tetrazolilo
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
DE69519382T3 (de) 1994-09-09 2008-09-18 Takeda Pharmaceutical Co. Ltd. Zubereitung mit verzögerter freigabe eines metallsalz eines peptids
JP3862304B2 (ja) 1994-09-09 2006-12-27 武田薬品工業株式会社 徐放性製剤
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US20010006943A1 (en) 1994-12-23 2001-07-05 Ejvind Jensen Protracted GLP-1 compositions
AU4298596A (en) 1994-12-23 1996-07-19 Novo Nordisk A/S Protracted glp-1 compositions
WO1997001331A2 (en) 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
DE19530865A1 (de) 1995-08-22 1997-02-27 Michael Dr Med Nauck Wirkstoff sowie Mittel zur parenteralen Ernährung
JP3902272B2 (ja) 1995-09-04 2007-04-04 武田薬品工業株式会社 徐放性製剤の製造法
TW448055B (en) 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5766620A (en) 1995-10-23 1998-06-16 Theratech, Inc. Buccal delivery of glucagon-like insulinotropic peptides
US5849322A (en) 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
JPH10265404A (ja) 1996-02-02 1998-10-06 Mitsui Chem Inc ヒト成長ホルモンを含有する医薬製剤
DK0891378T3 (da) 1996-03-01 2003-01-06 Novo Nordisk As Anvendelse af farmaceutisk formulering omfattende et appetitundertrykkende peptid
CZ300837B6 (cs) 1996-08-30 2009-08-26 Novo Nordisk A/S Deriváty GLP-1(7-37) nebo jeho analogy, farmaceutický prostredek je obsahující a jejich použití
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
JP4459315B2 (ja) 1996-12-20 2010-04-28 武田薬品工業株式会社 徐放性製剤の製造法
AU6586298A (en) 1997-03-31 1998-10-22 Eli Lilly And Company Glucagon-like peptide-1 analogs
JP2002510193A (ja) 1997-03-31 2002-04-02 イーライ・リリー・アンド・カンパニー グルカゴン様ペプチド−1類似体
DE69838552T2 (de) 1997-07-14 2008-05-21 Bolder Biotechnology, Inc., Louisville Derivate des wachstumshormons und verwandte proteine
US6391452B1 (en) * 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
AU749914B2 (en) 1997-08-08 2002-07-04 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
CA2312190A1 (en) 1997-12-05 1999-06-17 Eli Lilly And Company Glp-1 formulations
WO1999055310A1 (en) 1998-04-27 1999-11-04 Altus Biologics Inc. Stabilized protein crystals, formulations containing them and methods of making them
DE69942306D1 (de) 1998-02-27 2010-06-10 Novo Nordisk As Abkömmlinge von glp-1 analogen
EP1062240B1 (de) 1998-02-27 2010-04-28 Novo Nordisk A/S N-terminal veränderte glp-1 abkömmlinge
DE69916811T2 (de) 1998-02-27 2005-04-14 Novo Nordisk A/S Glp-1 derivate mit einem helix-gehalt über 25 %, die partiell strukturierte mizellenartige aggregate bilden
WO1999043708A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
WO1999043705A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S N-terminally truncated glp-1 derivatives
US6613358B2 (en) * 1998-03-18 2003-09-02 Theodore W. Randolph Sustained-release composition including amorphous polymer
CN1301172A (zh) 1998-03-20 2001-06-27 武田药品工业株式会社 生理活性多肽的缓释制剂及其生产
JP4758525B2 (ja) 1998-03-20 2011-08-31 武田薬品工業株式会社 生理活性ポリペプチドの徐放性製剤およびその製造法
CA2270320A1 (en) 1998-04-28 1999-10-28 Patricia Lee Brubaker Novel microsphere composition
OA11694A (en) 1998-06-12 2005-01-12 Bionebraska Inc Glucagon-like peptide-1 improves beta-cell response to glucose in subjects with impaired glucose tolerance.
EP1105460B1 (de) 1998-08-10 2009-10-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung
US6429197B1 (en) 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド
US6403672B1 (en) * 1998-11-30 2002-06-11 University Technology Corporation Preparation and use of photopolymerized microparticles
DE69938669D1 (de) 1998-12-07 2008-06-19 Sod Conseils Rech Applic Analoge des glucagon ähnlichen peptides-1 (glp-1)
RU2214418C2 (ru) 1998-12-07 2003-10-20 Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик Сас Аналоги glp-1
DK1140148T3 (da) 1998-12-22 2006-01-30 Lilly Co Eli Lagerholdbar formulering af glucagon-agtigt peptid-1
DK1140145T4 (da) 1999-01-14 2019-07-22 Amylin Pharmaceuticals Llc Hidtil ukendte exendinagonistformuleringer og fremgangsmåder til indgivelse deraf
NZ514916A (en) 1999-04-30 2004-06-25 Amylin Pharmaceuticals Inc Exendins and exendin agonists linked to polyethylene glycol polymers
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
DK1133312T3 (da) 1999-06-21 2008-01-02 Lilly Co Eli Synergistisk anvendelse af thiazolidindioner med glucagonlignende peptid-1 og agonister deraf til behandling af ikke-insulinafhængig diabetes
IT1318404B1 (it) * 2000-03-17 2003-08-25 Eurand Int Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
US20040121008A1 (en) * 2001-03-16 2004-06-24 Keiko Shiraishi Process for producing sustained release preparation
WO2003000192A2 (en) * 2001-06-22 2003-01-03 Raveendran Poovathinthodiyil Renewable, carbohydrate based co2-philes

Also Published As

Publication number Publication date
CA2430934C (en) 2011-06-21
EP1346722B1 (de) 2008-12-10
CA2430934A1 (en) 2002-06-06
EP1346722A1 (de) 2003-09-24
US20060241045A1 (en) 2006-10-26
US20040018240A1 (en) 2004-01-29
AU2002224124A1 (en) 2002-06-11
EP2062593A3 (de) 2011-08-17
WO2002043709A1 (fr) 2002-06-06
JP2009062389A (ja) 2009-03-26
EP2062593A2 (de) 2009-05-27
US7090869B2 (en) 2006-08-15
EP1346722A4 (de) 2005-08-03
DE60136958D1 (de) 2009-01-22

Similar Documents

Publication Publication Date Title
DE60136958D1 (de) Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
DE60144104D1 (de) Membranen mit gemischter matrix und pyrolisierten kohlenstoffsiebteilchen und verfahren zur herstellung derselben
DE50103340D1 (de) Verfahren zur herstellung aktivstoffhaltiger kapseln mit ultradünner wandschicht
DE60124469D1 (de) Polyimidesiloxanharz, Verfahren zur Herstellung und Polyimidesiloxanharzzusammensetzung
ATE426575T1 (de) Peptidenanostrukturen die fremdmaterial enthalten,und verfahren zur herstellung derselben
WO2002064193A3 (en) Microneedle devices and production thereof
DE69500992D1 (de) WäSSRIGES POLYURETHANPOLYMER, TRENNBESCHICHTUNG, KLEBEFILM UND VERFAHREN ZUR HERSTELLUNG
DE60116810D1 (de) Polyhydroxyalkanoat enthaltend 3-Hydroxythienyl-Alkansäure als Monomer und ein Verfahren zur Herstellung desselben
ATE330586T1 (de) Pharmazeutische tablette und eine verfahren zu deren herstellung
DE60036560D1 (de) Fluorkohlenstoff-polymerzusammensetzungen mit hydrophilen funktionellen gruppen und verfahren zur herstellung davon
DE3884214D1 (de) Verfahren zur herstellung einer festen form mit beibehaltender freisetzung aus einer funktionellen aktiven komposition und die bei dem verfahren erhaltene dosierungsform.
DE69617435D1 (de) Absorbierendes material, formkörper aus diesem material und verfahren zur herstellung des materials.
DE60121340D1 (de) Verfahren zur herstellung eines photochromen formteils
DE50207803D1 (de) Verfahren zur herstellung gesättigter alkohole, ketone, aldehyde und carbonsäuren
DE60207154D1 (de) Verfahren zur Herstellung amphoteren Polyurethanharzes, sowie daraus erhaltenes amphoteres Polyurethanharz und Harzzusammensetzung
DE50103605D1 (de) Verfahren zur Herstellung eines Spritzlings für pharmazeutische Anwendungen
DE60030183D1 (de) Verfahren zur Herstellung einer Membranvorrichtung mit interner Spülung
DE69008122D1 (de) Phenolnovolakharz, dessen härtungsprodukt und verfahren zur herstellung.
DE60119914D1 (de) Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden
DE60122725D1 (de) Organosiliciumverbindungen die polyorganosiloxane mit ethylenisch ungesättigten durch imidgruppen aktivierte gruppen enthalten und verfahren zur deren herstellung
ATE240205T1 (de) Verfahren zur entformung eines durchsichtigen gegenstandes und dessen anwendung zur herstellung eines gegenstandes aus durchsichtigem kunststoff wie z.b. einer kontaktlinse
DE60035130D1 (de) Verfahren zur Herstellung eines photochromen, gehärteten Produkts
DE50110813D1 (de) Kautschukfreie copolymerisate mit niedrigen monomerrestgehalten und verfahren und vorrichtung zur ihrer herstellung
ATE269396T1 (de) Verfahren zur herstellung von formkörpern
ATE503507T1 (de) Verfahren zur herstellung bioabsorbierbarer wirkstofffreisetzungsvorrichtungen aus lösungsmittelgegossenen filmen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties