DE60119914D1 - Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden - Google Patents

Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden

Info

Publication number
DE60119914D1
DE60119914D1 DE60119914T DE60119914T DE60119914D1 DE 60119914 D1 DE60119914 D1 DE 60119914D1 DE 60119914 T DE60119914 T DE 60119914T DE 60119914 T DE60119914 T DE 60119914T DE 60119914 D1 DE60119914 D1 DE 60119914D1
Authority
DE
Germany
Prior art keywords
active ingredient
compressed fluid
preparing compounds
compressed
compressed fluids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60119914T
Other languages
English (en)
Inventor
Italo Colombo
Paolo Pallado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Eurand International SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA filed Critical Eurand International SpA
Application granted granted Critical
Publication of DE60119914D1 publication Critical patent/DE60119914D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE60119914T 2000-03-17 2001-03-07 Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden Expired - Lifetime DE60119914D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000560A IT1318404B1 (it) 2000-03-17 2000-03-17 Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
PCT/EP2001/002538 WO2001068054A1 (en) 2000-03-17 2001-03-07 Process for the preparation of accelerated release formulations using compressed fluids

Publications (1)

Publication Number Publication Date
DE60119914D1 true DE60119914D1 (de) 2006-06-29

Family

ID=11444510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60119914T Expired - Lifetime DE60119914D1 (de) 2000-03-17 2001-03-07 Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden

Country Status (13)

Country Link
US (1) US6913779B2 (de)
EP (1) EP1267836B1 (de)
JP (1) JP2003526653A (de)
KR (1) KR20030070815A (de)
CN (1) CN1418090A (de)
AT (1) ATE326950T1 (de)
AU (1) AU4068201A (de)
BR (1) BR0109312A (de)
CA (1) CA2403343C (de)
DE (1) DE60119914D1 (de)
IT (1) IT1318404B1 (de)
MX (1) MXPA02009056A (de)
WO (1) WO2001068054A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7090869B2 (en) * 2000-12-01 2006-08-15 Takeda Pharmaceutical Company Limited Method for producing preparation containing bioactive substance
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
AU2003218685A1 (en) * 2002-03-07 2003-09-16 Eurand Pharmaceuticals Ltd Process for loading and thermodynamically activating drugs on polymers by means of supercritical fluids
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8389013B2 (en) * 2006-10-06 2013-03-05 Newsouth Innovations Pty Limited Process for producing particles via atomized rapid injection for solvent extraction
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (fr) * 2009-05-15 2012-10-05 Pf Medicament Procede d'impregnation par co2 supercritique
WO2010144865A2 (en) 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
CN105687141A (zh) * 2016-03-04 2016-06-22 中国药科大学 超临界抗溶剂法制备尼美舒利-左旋聚乳酸(Nim-PLLA)复合微球的工艺研究
CN110859807A (zh) * 2018-08-28 2020-03-06 康芝药业股份有限公司 一种尼美舒利的固体分散微粉及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225192A (en) * 1988-10-17 1993-07-06 Vectorpharma International S.P.A. Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
IT1230566B (it) * 1988-10-17 1991-10-28 Vectorpharma Int Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione
CA2017332A1 (en) * 1989-06-29 1990-12-29 Richard W. Greiner Pharmaceutically impregnated catheters
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation
DE69618938T2 (de) * 1995-03-28 2002-10-31 Fidia Advanced Biopolymers Srl Nanosphären mit einem biokompatiblen polysaccharid
IT1296464B1 (it) * 1997-11-19 1999-06-25 Vectorpharma Int Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
MXPA02011427A (es) * 2000-05-16 2004-09-10 Johnson & Johnson Procedimiento para revestir dispositivos medicos utilizando dioxido de carbono supercritico.

Also Published As

Publication number Publication date
CN1418090A (zh) 2003-05-14
ITMI20000560A1 (it) 2001-09-17
WO2001068054A1 (en) 2001-09-20
ITMI20000560A0 (it) 2000-03-17
CA2403343C (en) 2010-05-11
MXPA02009056A (es) 2004-09-06
IT1318404B1 (it) 2003-08-25
US20030161957A1 (en) 2003-08-28
ATE326950T1 (de) 2006-06-15
EP1267836B1 (de) 2006-05-24
US6913779B2 (en) 2005-07-05
CA2403343A1 (en) 2001-09-20
JP2003526653A (ja) 2003-09-09
AU4068201A (en) 2001-09-24
BR0109312A (pt) 2002-12-17
EP1267836A1 (de) 2003-01-02
KR20030070815A (ko) 2003-09-02

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Legal Events

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