DE60003933D1 - Verfahren zur herstellung von mikropartikeln - Google Patents

Verfahren zur herstellung von mikropartikeln

Info

Publication number
DE60003933D1
DE60003933D1 DE60003933T DE60003933T DE60003933D1 DE 60003933 D1 DE60003933 D1 DE 60003933D1 DE 60003933 T DE60003933 T DE 60003933T DE 60003933 T DE60003933 T DE 60003933T DE 60003933 D1 DE60003933 D1 DE 60003933D1
Authority
DE
Germany
Prior art keywords
polymer
active substance
producing microparticles
atomized
emulsified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60003933T
Other languages
English (en)
Other versions
DE60003933T2 (de
Inventor
Brita Sjoeblom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60003933D1 publication Critical patent/DE60003933D1/de
Application granted granted Critical
Publication of DE60003933T2 publication Critical patent/DE60003933T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DE60003933T 1999-09-10 2000-09-01 Verfahren zur herstellung von mikropartikeln Expired - Lifetime DE60003933T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9903236 1999-09-10
SE9903236A SE9903236D0 (sv) 1999-09-10 1999-09-10 Method to obtain microparticles
PCT/SE2000/001682 WO2001019345A1 (en) 1999-09-10 2000-09-01 Method to obtain microparticles

Publications (2)

Publication Number Publication Date
DE60003933D1 true DE60003933D1 (de) 2003-08-21
DE60003933T2 DE60003933T2 (de) 2004-06-03

Family

ID=20416948

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003933T Expired - Lifetime DE60003933T2 (de) 1999-09-10 2000-09-01 Verfahren zur herstellung von mikropartikeln

Country Status (12)

Country Link
US (2) US6753014B1 (de)
EP (1) EP1214058B1 (de)
JP (1) JP2003509361A (de)
AT (1) ATE245022T1 (de)
AU (1) AU775458B2 (de)
CA (1) CA2382005A1 (de)
DE (1) DE60003933T2 (de)
DK (1) DK1214058T3 (de)
ES (1) ES2200933T3 (de)
NZ (1) NZ517525A (de)
SE (1) SE9903236D0 (de)
WO (1) WO2001019345A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ276088A (en) 1993-11-19 1999-07-29 Janssen Pharmaceutica Nv [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone)
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
US6284283B1 (en) * 1999-10-21 2001-09-04 Alkermes Controlled Therapeutics, Inc. Method of producing sub-micron particles of biologically active agents and uses thereof
CN1407884B (zh) 1999-10-29 2012-06-20 欧罗赛铁克股份有限公司 控释氢可酮制剂
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
GB0004827D0 (en) * 2000-02-29 2000-04-19 Quadrant Holdings Cambridge Compositions
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US6824822B2 (en) 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
WO2002036099A1 (en) 2000-10-30 2002-05-10 Euro-Celtique S.A. Controlled release hydrocodone formulations
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles
AU2002366616A1 (en) * 2001-12-10 2003-06-23 Hte Aktiengesellschaft The High Throughput Experimentation Company Production and shaping of shaped bodies by means of low-temperature cooling and drying processes
GB2399084B (en) 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
CN100366249C (zh) * 2002-09-29 2008-02-06 天津帝士力投资控股集团有限公司 一种替莫唑胺控释给药系统
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
BRPI0417264A (pt) * 2003-12-19 2007-03-06 Alk Abello As processos para a preparação de uma batelada de um ingrediente farmacêutico ativo, um recipiente compreendendo criogránulos de um produto alérgeno, e um criogránulo de um produto alérgeno
AU2005209476B9 (en) * 2004-01-28 2008-10-16 Unilever Plc Porous materials and method of production thereof
GB0401947D0 (en) 2004-01-28 2004-03-03 Unilever Plc Porous bodies and method of production thereof
GB0401950D0 (en) * 2004-01-28 2004-03-03 Unilever Plc Porous bodies and method of production thereof
KR20100129799A (ko) 2004-04-15 2010-12-09 알케르메스,인코포레이티드 중합체 기재 지속적 방출 방법
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
ITRM20040539A1 (it) * 2004-11-02 2005-02-02 Mavi Sud S R L Preparati a base di chitina o suoi derivati per uso cosmetico o medico.
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8017152B2 (en) 2005-05-27 2011-09-13 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
EP1726299A3 (de) 2005-05-27 2007-04-18 StratoSphere Pharma AB Kerne und Mikrokapsel zur parenteralen Verabreichung sowie Verfahren zu deren Herstellung
JP2009514884A (ja) * 2005-11-04 2009-04-09 イーストマン ケミカル カンパニー 難溶性医薬活性剤の投与のためのカルボキシアルキルセルロースエステル
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US20080075777A1 (en) * 2006-07-31 2008-03-27 Kennedy Michael T Apparatus and methods for preparing solid particles
KR101200728B1 (ko) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 삼투성 전달 시스템 및 피스톤 조립체
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
GB0707612D0 (en) * 2007-04-19 2007-05-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US9504274B2 (en) 2009-01-27 2016-11-29 Frito-Lay North America, Inc. Methods of flavor encapsulation and matrix-assisted concentration of aqueous foods and products produced therefrom
US20100189845A1 (en) * 2009-01-27 2010-07-29 Frito-Lay North America Inc. Flavor Encapsulation and Method Thereof
MX352878B (es) 2009-09-28 2017-12-13 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
JP2013526523A (ja) 2010-05-11 2013-06-24 シマ ラブス インク． メトプロロールを含むアルコール耐性持続放出性経口剤形
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US20150118300A1 (en) 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP4278996A3 (de) 2015-06-03 2024-01-24 i2o Therapeutics, Inc. Systeme zum einsetzen eines implantats
EP3458084B1 (de) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Für den glucagonrezeptor selektive polypeptide und verfahren zu deren verwendung
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
JP2019131511A (ja) * 2018-01-31 2019-08-08 理研ビタミン株式会社 薬物含有粒子の製造方法
EP3965733A4 (de) 2019-05-07 2023-01-11 Clexio Biosciences Ltd. Esketamin enthaltende missbrauchssichere darreichungsformen
US20220062200A1 (en) 2019-05-07 2022-03-03 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4845950A (de) * 1971-10-13 1973-06-30
GB1403584A (en) * 1972-05-19 1975-08-28 Beecham Group Ltd Control medicaments
DK152744C (da) * 1982-08-13 1988-10-31 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat
JPS61218516A (ja) * 1985-03-25 1986-09-29 Ichimaru Fuarukosu Kk 徐放性マイクロカプセルの製造法
ATE99546T1 (de) 1989-05-01 1994-01-15 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.
US5017383A (en) * 1989-08-22 1991-05-21 Taisho Pharmaceutical Co., Ltd. Method of producing fine coated pharmaceutical preparation
US5102983A (en) * 1990-04-02 1992-04-07 United States Surgical Corporation Process for preparing foamed, bioabsorbable polymer particles
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
CA2182988A1 (en) * 1994-02-09 1995-08-17 Kinerton Limited Process for drying a material from solution
AU710347B2 (en) * 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
GB2329124B (en) * 1997-09-12 2002-05-08 Hiran Asoka Malinga Ratwatte Method of forming dose units of active agents

Also Published As

Publication number Publication date
US20040219222A1 (en) 2004-11-04
AU775458B2 (en) 2004-08-05
EP1214058B1 (de) 2003-07-16
JP2003509361A (ja) 2003-03-11
DE60003933T2 (de) 2004-06-03
SE9903236D0 (sv) 1999-09-10
NZ517525A (en) 2003-08-29
EP1214058A1 (de) 2002-06-19
ES2200933T3 (es) 2004-03-16
DK1214058T3 (da) 2003-11-03
CA2382005A1 (en) 2001-03-22
AU7463700A (en) 2001-04-17
US6753014B1 (en) 2004-06-22
ATE245022T1 (de) 2003-08-15
WO2001019345A1 (en) 2001-03-22

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Legal Events

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