ATE99546T1 - Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen. - Google Patents

Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.

Info

Publication number
ATE99546T1
ATE99546T1 AT90907640T AT90907640T ATE99546T1 AT E99546 T1 ATE99546 T1 AT E99546T1 AT 90907640 T AT90907640 T AT 90907640T AT 90907640 T AT90907640 T AT 90907640T AT E99546 T1 ATE99546 T1 AT E99546T1
Authority
AT
Austria
Prior art keywords
molecules
particles
biologically active
active molecules
production
Prior art date
Application number
AT90907640T
Other languages
English (en)
Inventor
Wayne R Gombotz
Michael S Healy
Larry R Brown
Henry E Auer
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE99546T1 publication Critical patent/ATE99546T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT90907640T 1989-05-01 1990-05-01 Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen. ATE99546T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34568489A 1989-05-01 1989-05-01
PCT/US1990/002421 WO1990013285A1 (en) 1989-05-01 1990-05-01 Process for producing small particles of biologically active molecules
EP90907640A EP0432232B1 (de) 1989-05-01 1990-05-01 Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen

Publications (1)

Publication Number Publication Date
ATE99546T1 true ATE99546T1 (de) 1994-01-15

Family

ID=23356054

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90907640T ATE99546T1 (de) 1989-05-01 1990-05-01 Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.

Country Status (10)

Country Link
US (1) US6569458B1 (de)
EP (1) EP0432232B1 (de)
JP (1) JPH0739339B2 (de)
AT (1) ATE99546T1 (de)
AU (1) AU620253B2 (de)
CA (1) CA2030551C (de)
DE (1) DE69005800T2 (de)
DK (1) DK0432232T3 (de)
ES (1) ES2062530T3 (de)
WO (1) WO1990013285A1 (de)

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EP0432232B1 (de) 1994-01-05
EP0432232A1 (de) 1991-06-19
ES2062530T3 (es) 1994-12-16
CA2030551A1 (en) 1990-11-02
DE69005800T2 (de) 1994-05-19
DK0432232T3 (da) 1994-01-31
CA2030551C (en) 1998-08-25
AU5635990A (en) 1990-11-29
DE69005800D1 (de) 1994-02-17
JPH04500527A (ja) 1992-01-30
AU620253B2 (en) 1992-02-13
US6569458B1 (en) 2003-05-27
WO1990013285A1 (en) 1990-11-15
JPH0739339B2 (ja) 1995-05-01

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