DE69535897D1 - Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin - Google Patents

Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin

Info

Publication number
DE69535897D1
DE69535897D1 DE69535897T DE69535897T DE69535897D1 DE 69535897 D1 DE69535897 D1 DE 69535897D1 DE 69535897 T DE69535897 T DE 69535897T DE 69535897 T DE69535897 T DE 69535897T DE 69535897 D1 DE69535897 D1 DE 69535897D1
Authority
DE
Germany
Prior art keywords
insulin
pulmonary delivery
composition
pulmonary
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535897T
Other languages
English (en)
Inventor
John S Patton
Linda Foster
Robert M Platz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26902263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69535897(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of DE69535897D1 publication Critical patent/DE69535897D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE69535897T 1994-03-07 1995-02-07 Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin Expired - Fee Related DE69535897D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20747294A 1994-03-07 1994-03-07
US38347595A 1995-02-01 1995-02-01

Publications (1)

Publication Number Publication Date
DE69535897D1 true DE69535897D1 (de) 2009-01-22

Family

ID=26902263

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69535897T Expired - Fee Related DE69535897D1 (de) 1994-03-07 1995-02-07 Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
DE69532884T Revoked DE69532884T2 (de) 1994-03-07 1995-02-07 Verfahren und mittel zur verabreichung von insulin über die lunge

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69532884T Revoked DE69532884T2 (de) 1994-03-07 1995-02-07 Verfahren und mittel zur verabreichung von insulin über die lunge

Country Status (23)

Country Link
US (6) US6685967B1 (de)
EP (3) EP2036541A1 (de)
JP (2) JPH10501519A (de)
KR (1) KR100419037B1 (de)
CN (1) CN1098679C (de)
AT (2) ATE416755T1 (de)
AU (1) AU689217B2 (de)
BR (1) BR9507023A (de)
CA (1) CA2183577C (de)
CZ (1) CZ295827B6 (de)
DE (2) DE69535897D1 (de)
DK (1) DK0748213T3 (de)
ES (2) ES2316917T3 (de)
FI (1) FI116195B (de)
HU (1) HUT75676A (de)
IL (1) IL112618A (de)
MX (1) MX9603936A (de)
MY (1) MY124282A (de)
NO (1) NO316661B1 (de)
NZ (1) NZ281112A (de)
PL (1) PL179443B1 (de)
PT (1) PT748213E (de)
WO (1) WO1995024183A1 (de)

Families Citing this family (301)

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AU1744995A (en) 1995-09-25
US20020192164A1 (en) 2002-12-19
ATE416755T1 (de) 2008-12-15
ES2316917T3 (es) 2009-04-16
DE69532884D1 (de) 2004-05-19
FI963468A (fi) 1996-09-04
ES2218543T3 (es) 2004-11-16
EP2036541A1 (de) 2009-03-18
JP2006077032A (ja) 2006-03-23
EP1462096B1 (de) 2008-12-10
FI963468A0 (fi) 1996-09-04
FI116195B (fi) 2005-10-14
HU9602454D0 (en) 1996-11-28
IL112618A0 (en) 1995-06-29
US20030053959A1 (en) 2003-03-20
US6685967B1 (en) 2004-02-03
CN1098679C (zh) 2003-01-15
AU689217B2 (en) 1998-03-26
US5997848A (en) 1999-12-07
HUT75676A (en) 1997-05-28
DK0748213T3 (da) 2004-08-02
KR970701534A (ko) 1997-04-12
ATE264096T1 (de) 2004-04-15
US7521069B2 (en) 2009-04-21
US20040096400A1 (en) 2004-05-20
PT748213E (pt) 2004-08-31
NO963745L (no) 1996-11-06
CN1152867A (zh) 1997-06-25
DE69532884T2 (de) 2004-09-02
WO1995024183A1 (en) 1995-09-14
EP0748213A1 (de) 1996-12-18
EP0748213A4 (de) 1998-03-04
US6737045B2 (en) 2004-05-18
MX9603936A (es) 1997-05-31
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IL112618A (en) 1999-10-28
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KR100419037B1 (ko) 2004-06-12
JPH10501519A (ja) 1998-02-10
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CA2183577A1 (en) 1995-09-14
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US20040096401A1 (en) 2004-05-20
CZ295827B6 (cs) 2005-11-16

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