TR200000374T2 - Akut akciğer harabiyeti ve fibrozitinin alfavbeta6 antagonistleriyle tedavisi. - Google Patents
Akut akciğer harabiyeti ve fibrozitinin alfavbeta6 antagonistleriyle tedavisi.Info
- Publication number
- TR200000374T2 TR200000374T2 TR2000/00374T TR200000374T TR200000374T2 TR 200000374 T2 TR200000374 T2 TR 200000374T2 TR 2000/00374 T TR2000/00374 T TR 2000/00374T TR 200000374 T TR200000374 T TR 200000374T TR 200000374 T2 TR200000374 T2 TR 200000374T2
- Authority
- TR
- Turkey
- Prior art keywords
- fibrosis
- antagonists
- treatment
- alfavbeta6
- acute lung
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 230000004761 fibrosis Effects 0.000 title abstract 2
- 206010069351 acute lung injury Diseases 0.000 title 1
- 208000005069 pulmonary fibrosis Diseases 0.000 title 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 231100000516 lung damage Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Akut akciger harabiyeti ve fibrozitinin tedavisi için HL47412 ve HL53949 antagonistlerini içeren terkipler ve yöntem.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5506097P | 1997-08-08 | 1997-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000374T2 true TR200000374T2 (tr) | 2000-09-21 |
Family
ID=21995323
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00374T TR200000374T2 (tr) | 1997-08-08 | 1998-08-07 | Akut akciğer harabiyeti ve fibrozitinin alfavbeta6 antagonistleriyle tedavisi. |
TR2002/02323T TR200202323T2 (tr) | 1997-08-08 | 1998-08-07 | Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/02323T TR200202323T2 (tr) | 1997-08-08 | 1998-08-07 | Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi |
Country Status (23)
Country | Link |
---|---|
US (5) | US20020004482A1 (tr) |
EP (3) | EP1930022B1 (tr) |
JP (2) | JP2001513333A (tr) |
KR (1) | KR100586202B1 (tr) |
CN (1) | CN1267224A (tr) |
AT (3) | ATE410179T1 (tr) |
AU (1) | AU739283B2 (tr) |
BR (1) | BR9814040A (tr) |
CA (1) | CA2297736A1 (tr) |
CY (2) | CY1110462T1 (tr) |
CZ (1) | CZ299768B6 (tr) |
DE (2) | DE69828614T2 (tr) |
DK (2) | DK1504764T3 (tr) |
EE (1) | EE04752B1 (tr) |
ES (3) | ES2235350T3 (tr) |
HU (1) | HU228900B1 (tr) |
IL (2) | IL134288A0 (tr) |
NZ (2) | NZ515955A (tr) |
PL (2) | PL199014B1 (tr) |
PT (3) | PT1930022E (tr) |
RU (1) | RU2221589C2 (tr) |
TR (2) | TR200000374T2 (tr) |
WO (1) | WO1999007405A1 (tr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962643A (en) * | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
DE69828614T2 (de) * | 1997-08-08 | 2006-02-09 | The Regents Of The University Of California, Oakland | Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6 |
CN1332714C (zh) * | 1999-04-22 | 2007-08-22 | 比奥根艾迪克Ma公司 | 整联蛋白α4亚单位的拮抗剂在制备治疗纤维变性的药物组合物中的用途 |
DE19929410A1 (de) * | 1999-06-26 | 2000-12-28 | Merck Patent Gmbh | Inhibitoren des Integrins avß6 |
US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
AUPR230500A0 (en) * | 2000-12-22 | 2001-01-25 | University Of Newcastle Research Associates Limited, The | A method of modulating map kinase mediated cellular activity and agents useful in same |
WO2002088307A2 (en) * | 2001-04-30 | 2002-11-07 | Eli Lilly And Company | Humanized antibodies |
WO2003100033A2 (en) * | 2002-03-13 | 2003-12-04 | Biogen Idec Ma Inc. | ANTI-αvβ6 ANTIBODIES |
WO2003087340A2 (en) * | 2002-04-12 | 2003-10-23 | Raven Biotechnologies, Inc. | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof |
PT1734996E (pt) * | 2004-04-02 | 2013-07-18 | Univ California | Métodos e composição para tratamento e prevenção de doenças associadas a integrina αvβ5 |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
BRPI0714381A2 (pt) | 2006-07-10 | 2013-03-05 | Biogen Idec Inc | composiÇÕes e mÉtodos para inibir crescimento de cÂnceres deficientes em smad4 |
ES2746925T3 (es) * | 2006-08-03 | 2020-03-09 | Medimmune Ltd | Anticuerpos dirigidos hacia alfaVbeta6 y uso de los mismos |
JP2010506944A (ja) * | 2006-10-19 | 2010-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | インテグリンαVβ6のアンタゴニストを用いる慢性喘息の処置および予防 |
HUE025283T2 (en) | 2007-08-02 | 2016-03-29 | Gilead Biologics Inc | LOX and LOX2 inhibitors and their use |
KR101046317B1 (ko) * | 2008-07-04 | 2011-07-05 | 이종대 | 조력발전 방법 및 그 장치 |
US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
CN102481347A (zh) | 2009-07-24 | 2012-05-30 | 加州大学董事会 | 治疗和预防整合素αvβ5相关疾病的方法及组合物 |
CA2771702A1 (en) | 2009-08-21 | 2011-02-24 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and loxl2 |
NZ598464A (en) * | 2009-08-21 | 2014-07-25 | Gilead Biologics Inc | Methods and compositions for treatment of pulmonary fibrotic disorders |
KR20130008021A (ko) * | 2010-02-04 | 2013-01-21 | 길리아드 바이오로직스, 인크. | 리실 산화효소-유사 2 (loxl2)에 결합하는 항체, 및 그를 위한 사용 방법 |
AU2013221585B2 (en) | 2012-02-17 | 2017-03-30 | Seagen Inc. | Antibodies to integrin alphavbeta6 and use of same to treat cancer |
WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
EP2784511A1 (en) | 2013-03-27 | 2014-10-01 | Universität Zürich | Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma |
JP6104312B2 (ja) * | 2014-06-19 | 2017-03-29 | 日東電工株式会社 | 組織再生促進剤 |
KR20200044066A (ko) | 2017-08-22 | 2020-04-28 | 바이오젠 엠에이 인코포레이티드 | 항-알파(v)베타(6) 항체를 함유하는 약제학적 조성물 및 투약 요법 |
US11827709B2 (en) | 2019-12-05 | 2023-11-28 | Seagen Inc. | Anti-AVB6 antibodies and antibody-drug conjugates |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5654270A (en) * | 1988-06-28 | 1997-08-05 | La Jolla Cancer Research Foundation | Use of fibromodulin to prevent or reduce dermal scarring |
JPH04503951A (ja) | 1988-12-20 | 1992-07-16 | ラ ホヤ キャンサー リサーチ ファウンデーション | 創傷治癒に活性のあるポリペプチド―ポリマー複合体 |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5514788A (en) * | 1993-05-17 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
US5962643A (en) | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
US5770565A (en) * | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
US6492332B1 (en) * | 1995-12-12 | 2002-12-10 | Omeros Corporation | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation |
PT719859E (pt) * | 1994-12-20 | 2003-11-28 | Merck Patent Gmbh | Anticorpo monoclonal anti-alfa v-integrina |
DE69828614T2 (de) * | 1997-08-08 | 2006-02-09 | The Regents Of The University Of California, Oakland | Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6 |
-
1998
- 1998-08-07 DE DE69828614T patent/DE69828614T2/de not_active Expired - Lifetime
- 1998-08-07 PL PL341029A patent/PL199014B1/pl unknown
- 1998-08-07 JP JP2000506994A patent/JP2001513333A/ja not_active Withdrawn
- 1998-08-07 NZ NZ515955A patent/NZ515955A/xx not_active IP Right Cessation
- 1998-08-07 TR TR2000/00374T patent/TR200000374T2/tr unknown
- 1998-08-07 DK DK04022921T patent/DK1504764T3/da active
- 1998-08-07 AU AU87743/98A patent/AU739283B2/en not_active Expired
- 1998-08-07 CA CA002297736A patent/CA2297736A1/en not_active Abandoned
- 1998-08-07 RU RU2000105905/14A patent/RU2221589C2/ru active
- 1998-08-07 PT PT08004714T patent/PT1930022E/pt unknown
- 1998-08-07 PL PL384372A patent/PL201716B1/pl unknown
- 1998-08-07 KR KR1020007001337A patent/KR100586202B1/ko not_active IP Right Cessation
- 1998-08-07 TR TR2002/02323T patent/TR200202323T2/tr unknown
- 1998-08-07 BR BR9814040-0A patent/BR9814040A/pt not_active Application Discontinuation
- 1998-08-07 CN CN98807892A patent/CN1267224A/zh active Pending
- 1998-08-07 AT AT04022921T patent/ATE410179T1/de active
- 1998-08-07 EP EP08004714A patent/EP1930022B1/en not_active Expired - Lifetime
- 1998-08-07 AT AT98939278T patent/ATE286742T1/de active
- 1998-08-07 EP EP98939278A patent/EP0996460B1/en not_active Expired - Lifetime
- 1998-08-07 ES ES98939278T patent/ES2235350T3/es not_active Expired - Lifetime
- 1998-08-07 ES ES08004714T patent/ES2364703T3/es not_active Expired - Lifetime
- 1998-08-07 CZ CZ20000413A patent/CZ299768B6/cs not_active IP Right Cessation
- 1998-08-07 HU HU0003547A patent/HU228900B1/hu unknown
- 1998-08-07 PT PT04022921T patent/PT1504764E/pt unknown
- 1998-08-07 DE DE69840113T patent/DE69840113D1/de not_active Expired - Lifetime
- 1998-08-07 EP EP04022921A patent/EP1504764B1/en not_active Expired - Lifetime
- 1998-08-07 AT AT08004714T patent/ATE511850T1/de active
- 1998-08-07 ES ES04022921T patent/ES2311131T3/es not_active Expired - Lifetime
- 1998-08-07 DK DK08004714.5T patent/DK1930022T3/da active
- 1998-08-07 IL IL13428898A patent/IL134288A0/xx unknown
- 1998-08-07 PT PT98939278T patent/PT996460E/pt unknown
- 1998-08-07 WO PCT/US1998/016439 patent/WO1999007405A1/en active Application Filing
- 1998-08-07 EE EEP200000068A patent/EE04752B1/xx unknown
- 1998-08-07 US US09/130,870 patent/US20020004482A1/en not_active Abandoned
- 1998-08-07 NZ NZ502546A patent/NZ502546A/en not_active IP Right Cessation
-
1999
- 1999-08-02 US US09/365,695 patent/US6316601B1/en not_active Expired - Lifetime
-
2000
- 2000-01-30 IL IL134288A patent/IL134288A/en not_active IP Right Cessation
-
2001
- 2001-03-27 US US09/818,416 patent/US6692741B2/en not_active Expired - Lifetime
-
2004
- 2004-01-09 US US10/754,435 patent/US7150871B2/en not_active Expired - Lifetime
-
2006
- 2006-11-13 US US11/559,172 patent/US7544358B2/en not_active Expired - Fee Related
-
2008
- 2008-08-11 JP JP2008206826A patent/JP2009001587A/ja active Pending
-
2009
- 2009-01-08 CY CY20091100011T patent/CY1110462T1/el unknown
-
2011
- 2011-08-26 CY CY20111100822T patent/CY1111792T1/el unknown
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