DK1930022T3 - Behandling af blærefibrose med antistoffer mod alfa-V-beta-6-integrin - Google Patents

Behandling af blærefibrose med antistoffer mod alfa-V-beta-6-integrin

Info

Publication number
DK1930022T3
DK1930022T3 DK08004714.5T DK08004714T DK1930022T3 DK 1930022 T3 DK1930022 T3 DK 1930022T3 DK 08004714 T DK08004714 T DK 08004714T DK 1930022 T3 DK1930022 T3 DK 1930022T3
Authority
DK
Denmark
Prior art keywords
integrin
beta
treatment
antibodies against
against alpha
Prior art date
Application number
DK08004714.5T
Other languages
English (en)
Inventor
Xiaozhu Huang
Dean Sheppard
Robert Pytela
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK1930022T3 publication Critical patent/DK1930022T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK08004714.5T 1997-08-08 1998-08-07 Behandling af blærefibrose med antistoffer mod alfa-V-beta-6-integrin DK1930022T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5506097P 1997-08-08 1997-08-08
EP04022921A EP1504764B1 (en) 1997-08-08 1998-08-07 Treatment of liver fibrosis with antibodies against alpha V beta 6 integrin

Publications (1)

Publication Number Publication Date
DK1930022T3 true DK1930022T3 (da) 2011-07-25

Family

ID=21995323

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04022921T DK1504764T3 (da) 1997-08-08 1998-08-07 Behandling af leverfibrose med antistoffer mod alfa-V-beta-6-integrin
DK08004714.5T DK1930022T3 (da) 1997-08-08 1998-08-07 Behandling af blærefibrose med antistoffer mod alfa-V-beta-6-integrin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04022921T DK1504764T3 (da) 1997-08-08 1998-08-07 Behandling af leverfibrose med antistoffer mod alfa-V-beta-6-integrin

Country Status (23)

Country Link
US (5) US20020004482A1 (da)
EP (3) EP1504764B1 (da)
JP (2) JP2001513333A (da)
KR (1) KR100586202B1 (da)
CN (1) CN1267224A (da)
AT (3) ATE511850T1 (da)
AU (1) AU739283B2 (da)
BR (1) BR9814040A (da)
CA (1) CA2297736A1 (da)
CY (2) CY1110462T1 (da)
CZ (1) CZ299768B6 (da)
DE (2) DE69828614T2 (da)
DK (2) DK1504764T3 (da)
EE (1) EE04752B1 (da)
ES (3) ES2311131T3 (da)
HU (1) HU228900B1 (da)
IL (2) IL134288A0 (da)
NZ (2) NZ515955A (da)
PL (2) PL201716B1 (da)
PT (3) PT996460E (da)
RU (1) RU2221589C2 (da)
TR (2) TR200000374T2 (da)
WO (1) WO1999007405A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962643A (en) * 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
ATE511850T1 (de) * 1997-08-08 2011-06-15 Univ California Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin
CN1191860C (zh) * 1999-04-22 2005-03-09 比奥根公司 利用整联蛋白α4亚单位的拮抗剂治疗纤维变性的方法
DE19929410A1 (de) * 1999-06-26 2000-12-28 Merck Patent Gmbh Inhibitoren des Integrins avß6
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
AUPR230500A0 (en) * 2000-12-22 2001-01-25 University Of Newcastle Research Associates Limited, The A method of modulating map kinase mediated cellular activity and agents useful in same
EP1385544B1 (en) * 2001-04-30 2008-09-24 Eli Lilly And Company Humanized antibodies
CA2478833C (en) * 2002-03-13 2015-11-10 Biogen, Inc. Anti-.alpha.v.beta.6 antibodies
AU2003230929A1 (en) * 2002-04-12 2003-10-27 Raven Biotechnologies, Inc. Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
RS52918B (en) * 2004-04-02 2014-02-28 The Regents Of The University Of California PROCEDURES AND MIXTURES FOR TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH ALFA V BETA 5 INTEGRINE
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
US8795668B2 (en) * 2005-12-23 2014-08-05 The Regents Of The University Of Michigan Methods for treating pulmonary fibrosis
KR20090027241A (ko) 2006-07-10 2009-03-16 바이오겐 아이덱 엠에이 인코포레이티드 Ｓｍａｄ４-결핍 암의 성장을 억제하기 위한 조성물 및 방법
ES2746925T3 (es) * 2006-08-03 2020-03-09 Medimmune Ltd Anticuerpos dirigidos hacia alfaVbeta6 y uso de los mismos
AU2007354317A1 (en) * 2006-10-19 2008-12-04 Biogen Idec Ma Inc. Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6
PL2185198T3 (pl) * 2007-08-02 2015-06-30 Gilead Biologics Inc Inhibitory LOX i L0XL2 oraz ich zastosowania
KR101046317B1 (ko) * 2008-07-04 2011-07-05 이종대 조력발전 방법 및 그 장치
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US10087252B2 (en) 2009-07-24 2018-10-02 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with αvβ5 integrin
CA2771778A1 (en) * 2009-08-21 2011-02-24 Gilead Biologics, Inc. Methods and compositions for treatment of pulmonary fibrotic disorders
SG2014004816A (en) 2009-08-21 2014-03-28 Gilead Biologics Inc Catalytic domains from lysyl oxidase and loxl2
CA2789022A1 (en) * 2010-02-04 2011-08-11 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
CN105017420B (zh) 2012-02-17 2019-05-28 西雅图基因公司 针对整联蛋白αvβ6的抗体和使用该抗体治疗癌症
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
JP6104312B2 (ja) * 2014-06-19 2017-03-29 日東電工株式会社 組織再生促進剤
BR112020003498A2 (pt) 2017-08-22 2020-08-25 Biogen Ma, Inc. composições farmacêuticas e regimes de dosagem que contêm anticorpos anti-alfa(v)beta(6)
BR112022009570A2 (pt) 2019-12-05 2022-08-02 Seagen Inc Anticorpo anti-¿v¿6 isolado ou fragmento de ligação ao antígeno, conjugado anticorpo-fármaco, ácido nucleico, vetor, célula hospedeira, métodos para produção de um anticorpo anti-¿v¿6 ou fragmento de ligação ao antígeno, para produção de um conjugado anticorpo anti-¿v¿6-fármaco e para tratamento de câncer em um indivíduo, e, composição farmacêutica

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5654270A (en) * 1988-06-28 1997-08-05 La Jolla Cancer Research Foundation Use of fibromodulin to prevent or reduce dermal scarring
JPH04503951A (ja) 1988-12-20 1992-07-16 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 創傷治癒に活性のあるポリペプチド―ポリマー複合体
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5514788A (en) * 1993-05-17 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
SI0719859T1 (en) * 1994-12-20 2003-12-31 Merck Patent Gmbh Anti-alpha V-integrin monoclonal antibody
ATE511850T1 (de) * 1997-08-08 2011-06-15 Univ California Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin

Also Published As

Publication number Publication date
NZ502546A (en) 2002-02-01
TR200000374T2 (tr) 2000-09-21
EP0996460A1 (en) 2000-05-03
ES2235350T3 (es) 2005-07-01
KR100586202B1 (ko) 2006-06-07
EP1930022A1 (en) 2008-06-11
WO1999007405A1 (en) 1999-02-18
PT996460E (pt) 2005-04-29
CY1110462T1 (el) 2015-04-29
ATE410179T1 (de) 2008-10-15
AU739283B2 (en) 2001-10-11
IL134288A (en) 2008-07-08
US6692741B2 (en) 2004-02-17
DE69828614T2 (de) 2006-02-09
EE04752B1 (et) 2006-12-15
DE69840113D1 (de) 2008-11-20
JP2009001587A (ja) 2009-01-08
EP0996460A4 (en) 2001-03-07
PT1504764E (pt) 2009-01-14
CY1111792T1 (el) 2015-10-07
US20070148173A1 (en) 2007-06-28
HUP0003547A2 (hu) 2001-02-28
US20020004482A1 (en) 2002-01-10
KR20010022740A (ko) 2001-03-26
CZ2000413A3 (cs) 2000-11-15
US6316601B1 (en) 2001-11-13
EE200000068A (et) 2000-10-16
BR9814040A (pt) 2000-10-03
EP0996460B1 (en) 2005-01-12
US7544358B2 (en) 2009-06-09
EP1930022B1 (en) 2011-06-08
ES2311131T3 (es) 2009-02-01
AU8774398A (en) 1999-03-01
CA2297736A1 (en) 1999-02-18
EP1504764A1 (en) 2005-02-09
US20010056076A1 (en) 2001-12-27
ATE511850T1 (de) 2011-06-15
NZ515955A (en) 2003-04-29
RU2221589C2 (ru) 2004-01-20
CZ299768B6 (cs) 2008-11-19
PL199014B1 (pl) 2008-08-29
IL134288A0 (en) 2001-04-30
DK1504764T3 (da) 2008-11-17
PL201716B1 (pl) 2009-05-29
DE69828614D1 (de) 2005-02-17
JP2001513333A (ja) 2001-09-04
ES2364703T3 (es) 2011-09-12
PL341029A1 (en) 2001-03-26
EP1504764B1 (en) 2008-10-08
HU228900B1 (en) 2013-06-28
US20040208878A1 (en) 2004-10-21
US7150871B2 (en) 2006-12-19
HUP0003547A3 (en) 2002-05-28
ATE286742T1 (de) 2005-01-15
TR200202323T2 (tr) 2002-12-23
PT1930022E (pt) 2011-08-01
CN1267224A (zh) 2000-09-20

Similar Documents

Publication Publication Date Title
DK1930022T3 (da) Behandling af blærefibrose med antistoffer mod alfa-V-beta-6-integrin
HK1029513A1 (en) Anticoagulant humanised antibodies against factor ix, for use in the treatment of thrombosis
DE60121988D1 (de) Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln
EP1550456A3 (en) Use of botulinum toxin in the treatment of burn pain
CY2007001I1 (el) Φαρμακευτικο σκευασμα για χρηση στη θεραπεια του διαβητη
CY2013010I1 (el) ΑΝΘΡΩΠΟΠΟΙΗΜΕΝΑ ΑΝΤΙΣΩΜΑΤΑ ΑΝΤΙ-ErbB2 ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΜΕ ΑΝΤΙΣΩΜΑΤΑ ΑΝΤΙ-ErbB2
SG136804A1 (en) Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
HK1109160A1 (en) Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
FI962038A0 (fi) Kertakäyttövaippa, jossa on joustaviksi tehdyt lahjekäänteet
DK0907358T3 (da) Behandling med ensartet afgivelse af lægemiddel
DE60022930D1 (de) Wegwerfwindel mit elastischen dichten Rändern
DK1007055T3 (da) Anvendelse af amifostin
TR200103432T2 (tr) Engelleyici monoklonal VLA-1 antikoru ve enflamasyonlu hastalıkların tedavisinde kullanımı.
DE69511148T2 (de) Wegwerfwindel mit verbessertem Abschluss an den Beinteilen
FI973185A (fi) Melatoniinin käyttö lääkeriippuvuudesta kärsivien potilaiden hoitoon
ID21895A (id) Antibodi yang mengikat kepada grup laminin yang mengikat nidogen, pembuatannya dan penggunaannya
EP1013642A3 (de) Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
ATE183069T1 (de) Wergwerfwindel mit taillenpolster
IS4387A (is) Nýtt skömmtunarform hýdroxókóbalamíns og notkun þess við sýaníðeitrunum
DK0900085T3 (da) Behandling af overdreven aggression med olanzapin
DE69118702D1 (de) Neue verwendung eines monoklonalen antikörpers
RU99123884A (ru) Способ лечения параноидной шизофрении
UA38888A (uk) Спосіб лікування хронічного вірусного гепатиту