TR200202323T2 - Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi - Google Patents

Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi

Info

Publication number
TR200202323T2
TR200202323T2 TR2002/02323T TR200202323T TR200202323T2 TR 200202323 T2 TR200202323 T2 TR 200202323T2 TR 2002/02323 T TR2002/02323 T TR 2002/02323T TR 200202323 T TR200202323 T TR 200202323T TR 200202323 T2 TR200202323 T2 TR 200202323T2
Authority
TR
Turkey
Prior art keywords
fibrosis
antagonists
treatment
alfavß6
acute lung
Prior art date
Application number
TR2002/02323T
Other languages
English (en)
Inventor
Huang Xiazozhu
Sheppard Dean
Pytela Robert
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of TR200202323T2 publication Critical patent/TR200202323T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

Akut akciger harabiyeti ve fibrozitinin tedavisi için alfav 6 antagonistlerini içeren terkipler ve yöntem.
TR2002/02323T 1997-08-08 1998-08-07 Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi TR200202323T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5506097P 1997-08-08 1997-08-08

Publications (1)

Publication Number Publication Date
TR200202323T2 true TR200202323T2 (tr) 2002-12-23

Family

ID=21995323

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/00374T TR200000374T2 (tr) 1997-08-08 1998-08-07 Akut akciğer harabiyeti ve fibrozitinin alfavbeta6 antagonistleriyle tedavisi.
TR2002/02323T TR200202323T2 (tr) 1997-08-08 1998-08-07 Akut akciğer harabiyeti ve fibrozitinin alfavß6 antagonistleriyle tedavisi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/00374T TR200000374T2 (tr) 1997-08-08 1998-08-07 Akut akciğer harabiyeti ve fibrozitinin alfavbeta6 antagonistleriyle tedavisi.

Country Status (23)

Country Link
US (5) US20020004482A1 (tr)
EP (3) EP1930022B1 (tr)
JP (2) JP2001513333A (tr)
KR (1) KR100586202B1 (tr)
CN (1) CN1267224A (tr)
AT (3) ATE410179T1 (tr)
AU (1) AU739283B2 (tr)
BR (1) BR9814040A (tr)
CA (1) CA2297736A1 (tr)
CY (2) CY1110462T1 (tr)
CZ (1) CZ299768B6 (tr)
DE (2) DE69828614T2 (tr)
DK (2) DK1504764T3 (tr)
EE (1) EE04752B1 (tr)
ES (3) ES2235350T3 (tr)
HU (1) HU228900B1 (tr)
IL (2) IL134288A0 (tr)
NZ (2) NZ515955A (tr)
PL (2) PL199014B1 (tr)
PT (3) PT996460E (tr)
RU (1) RU2221589C2 (tr)
TR (2) TR200000374T2 (tr)
WO (1) WO1999007405A1 (tr)

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US5962643A (en) * 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
WO1999007405A1 (en) * 1997-08-08 1999-02-18 The Regents Of The University Of California TREATMENT OF ACUTE LUNG INJURY AND FIBROSIS WITH ANTAGONISTS OF αvβ6
CA2370814C (en) * 1999-04-22 2010-07-06 Biogen, Inc. Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit
DE19929410A1 (de) * 1999-06-26 2000-12-28 Merck Patent Gmbh Inhibitoren des Integrins avß6
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
AUPR230500A0 (en) * 2000-12-22 2001-01-25 University Of Newcastle Research Associates Limited, The A method of modulating map kinase mediated cellular activity and agents useful in same
US7320790B2 (en) * 2001-04-30 2008-01-22 Eli Lilly And Company Humanized antibodies
EP2287198A3 (en) * 2002-03-13 2011-05-25 Biogen Idec MA Inc. Anti-alpha V beta 6 antibodies
US20040048312A1 (en) * 2002-04-12 2004-03-11 Ronghao Li Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
PL1734996T3 (pl) * 2004-04-02 2013-09-30 Univ California Sposoby i kompozycje do leczenia i profilaktyki choroby związanej z integryną alfa v beta 5
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
US8795668B2 (en) * 2005-12-23 2014-08-05 The Regents Of The University Of Michigan Methods for treating pulmonary fibrosis
US7927590B2 (en) 2006-07-10 2011-04-19 Biogen Idec Ma Inc. Compositions and methods for inhibiting growth of smad4-deficient cancers
CN103524619B (zh) * 2006-08-03 2016-10-05 阿斯利康(瑞典)有限公司 针对αVβ6的抗体及其应用
AU2007354317A1 (en) * 2006-10-19 2008-12-04 Biogen Idec Ma Inc. Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6
US8461303B2 (en) 2007-08-02 2013-06-11 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
KR101046317B1 (ko) * 2008-07-04 2011-07-05 이종대 조력발전 방법 및 그 장치
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
WO2011011775A1 (en) 2009-07-24 2011-01-27 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with avb5 integrin
US20110044981A1 (en) * 2009-08-21 2011-02-24 Spangler Rhyannon Methods and compositions for treatment of pulmonary fibrotic disorders
RU2012110585A (ru) 2009-08-21 2013-09-27 Джилид Байолоджикс, Инк. Каталичические домены лизилоксидазы и loxl2
CN105622757A (zh) * 2010-02-04 2016-06-01 吉联亚生物科技有限公司 结合赖氨酰氧化酶样2（loxl2）的抗体和其使用方法
JP6273214B2 (ja) 2012-02-17 2018-01-31 シアトル ジェネティックス， インコーポレイテッド がんを処置するためのインテグリンαｖβ６に対する抗体およびその使用
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
JP6104312B2 (ja) * 2014-06-19 2017-03-29 日東電工株式会社 組織再生促進剤
CN111201036A (zh) 2017-08-22 2020-05-26 比奥根Ma公司 包含抗α(V)β(6)抗体的药物组合物和剂量方案
WO2021113697A1 (en) 2019-12-05 2021-06-10 Seagen Inc. Anti-avb6 antibodies and antibody-drug conjugates

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WO1990006767A1 (en) 1988-12-20 1990-06-28 La Jolla Cancer Research Foundation Polypeptide-polymer conjugates active in wound healing
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US5514788A (en) * 1993-05-17 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
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WO1999007405A1 (en) * 1997-08-08 1999-02-18 The Regents Of The University Of California TREATMENT OF ACUTE LUNG INJURY AND FIBROSIS WITH ANTAGONISTS OF αvβ6

Also Published As

Publication number Publication date
DK1930022T3 (da) 2011-07-25
PT1930022E (pt) 2011-08-01
EP1504764B1 (en) 2008-10-08
EP1930022B1 (en) 2011-06-08
ATE286742T1 (de) 2005-01-15
EP1504764A1 (en) 2005-02-09
PT1504764E (pt) 2009-01-14
ES2311131T3 (es) 2009-02-01
TR200000374T2 (tr) 2000-09-21
IL134288A (en) 2008-07-08
PT996460E (pt) 2005-04-29
CY1111792T1 (el) 2015-10-07
CZ299768B6 (cs) 2008-11-19
CZ2000413A3 (cs) 2000-11-15
HUP0003547A2 (hu) 2001-02-28
BR9814040A (pt) 2000-10-03
EP0996460A1 (en) 2000-05-03
CN1267224A (zh) 2000-09-20
US6316601B1 (en) 2001-11-13
US7150871B2 (en) 2006-12-19
US20040208878A1 (en) 2004-10-21
EP1930022A1 (en) 2008-06-11
US20070148173A1 (en) 2007-06-28
DK1504764T3 (da) 2008-11-17
IL134288A0 (en) 2001-04-30
AU739283B2 (en) 2001-10-11
EE200000068A (et) 2000-10-16
RU2221589C2 (ru) 2004-01-20
EE04752B1 (et) 2006-12-15
JP2001513333A (ja) 2001-09-04
HUP0003547A3 (en) 2002-05-28
WO1999007405A1 (en) 1999-02-18
KR20010022740A (ko) 2001-03-26
HU228900B1 (en) 2013-06-28
DE69840113D1 (de) 2008-11-20
EP0996460A4 (en) 2001-03-07
PL201716B1 (pl) 2009-05-29
ATE511850T1 (de) 2011-06-15
AU8774398A (en) 1999-03-01
PL341029A1 (en) 2001-03-26
KR100586202B1 (ko) 2006-06-07
US6692741B2 (en) 2004-02-17
US7544358B2 (en) 2009-06-09
ES2235350T3 (es) 2005-07-01
ES2364703T3 (es) 2011-09-12
NZ502546A (en) 2002-02-01
DE69828614D1 (de) 2005-02-17
JP2009001587A (ja) 2009-01-08
EP0996460B1 (en) 2005-01-12
US20010056076A1 (en) 2001-12-27
CA2297736A1 (en) 1999-02-18
ATE410179T1 (de) 2008-10-15
US20020004482A1 (en) 2002-01-10
PL199014B1 (pl) 2008-08-29
NZ515955A (en) 2003-04-29
DE69828614T2 (de) 2006-02-09
CY1110462T1 (el) 2015-04-29

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