DE69832158D1 - Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18 - Google Patents

Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18

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Publication number
DE69832158D1
DE69832158D1 DE69832158T DE69832158T DE69832158D1 DE 69832158 D1 DE69832158 D1 DE 69832158D1 DE 69832158 T DE69832158 T DE 69832158T DE 69832158 T DE69832158 T DE 69832158T DE 69832158 D1 DE69832158 D1 DE 69832158D1
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DE
Germany
Prior art keywords
dolastatin
cryostatic
linears
depsipeptides
cyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE69832158T
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English (en)
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DE69832158T2 (de
Inventor
R Pettit
Jun-Ping Xu
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ARIZONA BOARD OF REGENTS TEMPE
Arizona Board of Regents of ASU
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ARIZONA BOARD OF REGENTS TEMPE
Arizona Board of Regents of ASU
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Publication of DE69832158D1 publication Critical patent/DE69832158D1/de
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Publication of DE69832158T2 publication Critical patent/DE69832158T2/de
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Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043Leu-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DE69832158T 1997-02-25 1998-02-23 Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18 Expired - Fee Related DE69832158T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4442697P 1997-02-25 1997-02-25
US44426P 1997-02-25
PCT/US1998/003455 WO1998036765A1 (en) 1997-02-25 1998-02-23 Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18

Publications (2)

Publication Number Publication Date
DE69832158D1 true DE69832158D1 (de) 2005-12-08
DE69832158T2 DE69832158T2 (de) 2006-08-10

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Family Applications (1)

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DE69832158T Expired - Fee Related DE69832158T2 (de) 1997-02-25 1998-02-23 Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18

Country Status (6)

Country Link
US (1) US6239104B1 (de)
EP (1) EP0973540B1 (de)
JP (1) JP2002513402A (de)
CA (1) CA2282504A1 (de)
DE (1) DE69832158T2 (de)
WO (1) WO1998036765A1 (de)

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