IT1247472B - Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. - Google Patents

Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.

Info

Publication number
IT1247472B
IT1247472B ITPD910102A ITPD910102A IT1247472B IT 1247472 B IT1247472 B IT 1247472B IT PD910102 A ITPD910102 A IT PD910102A IT PD910102 A ITPD910102 A IT PD910102A IT 1247472 B IT1247472 B IT 1247472B
Authority
IT
Italy
Prior art keywords
preparation
biologically active
active components
microspheres containing
containing biologically
Prior art date
Application number
ITPD910102A
Other languages
English (en)
Inventor
Lanfranco Callegaro
Aurelio Romeo
Luca Benedetti
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of ITPD910102A0 publication Critical patent/ITPD910102A0/it
Priority to ITPD910102A priority Critical patent/IT1247472B/it
Priority to DE69231507T priority patent/DE69231507T2/de
Priority to EP99202579A priority patent/EP0979648A3/en
Priority to AT92401433T priority patent/ATE196991T1/de
Priority to EP92401433A priority patent/EP0517565B1/en
Priority to ES92401433T priority patent/ES2153355T3/es
Priority to CA002070095A priority patent/CA2070095C/en
Priority to JP4139012A priority patent/JPH07179363A/ja
Publication of ITPD910102A1 publication Critical patent/ITPD910102A1/it
Priority to US08/169,558 priority patent/US6066340A/en
Application granted granted Critical
Publication of IT1247472B publication Critical patent/IT1247472B/it
Priority to US09/231,353 priority patent/US6039970A/en
Priority to GR20000402482T priority patent/GR3034789T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Oggetto dell'invenzione è una composizione di microsfere ed un processo per la loro preparazione, a partire da polimeri semisintetici biodegradabili e bioriassorbibili e da singole molecole o loro miscele aventi attività farmacologiche, che permetta di mantenere inalterate le caratteristiche chimiche del polimero semisintetico impiegato, l'attività farmacologica o biologica delle molecole, garantendo un rilascio controllato in funzione dell'idrofilicità del sostituente chimico presente sul polimero semisintetico.
ITPD910102A 1991-05-31 1991-05-31 Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. IT1247472B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITPD910102A IT1247472B (it) 1991-05-31 1991-05-31 Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
DE69231507T DE69231507T2 (de) 1991-05-31 1992-05-26 Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren
EP99202579A EP0979648A3 (en) 1991-05-31 1992-05-26 Microspheres of esters of hyaluronic acid for controlled release of an active
AT92401433T ATE196991T1 (de) 1991-05-31 1992-05-26 Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospheren
EP92401433A EP0517565B1 (en) 1991-05-31 1992-05-26 Process for the preparation of microspheres containing biologically active components
ES92401433T ES2153355T3 (es) 1991-05-31 1992-05-26 Procedimiento para la preparacion de microesferas que contienen compuestos biologicamente activos.
CA002070095A CA2070095C (en) 1991-05-31 1992-05-29 Microspheres containing biologically-active components, processes for the preparation and uses
JP4139012A JPH07179363A (ja) 1991-05-31 1992-05-29 生物学的に活性な成分を含有するミクロスフェアの製造方法
US08/169,558 US6066340A (en) 1991-05-31 1993-12-20 Process for the preparation of microspheres containing biologically active components
US09/231,353 US6039970A (en) 1991-05-31 1999-01-13 Process for the preparation of microspheres containing biologically active components
GR20000402482T GR3034789T3 (en) 1991-05-31 2000-11-08 Process for the preparation of microspheres containing biologically active components.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD910102A IT1247472B (it) 1991-05-31 1991-05-31 Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.

Publications (3)

Publication Number Publication Date
ITPD910102A0 ITPD910102A0 (it) 1991-05-31
ITPD910102A1 ITPD910102A1 (it) 1992-12-01
IT1247472B true IT1247472B (it) 1994-12-17

Family

ID=11389598

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD910102A IT1247472B (it) 1991-05-31 1991-05-31 Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.

Country Status (9)

Country Link
US (2) US6066340A (it)
EP (2) EP0979648A3 (it)
JP (1) JPH07179363A (it)
AT (1) ATE196991T1 (it)
CA (1) CA2070095C (it)
DE (1) DE69231507T2 (it)
ES (1) ES2153355T3 (it)
GR (1) GR3034789T3 (it)
IT (1) IT1247472B (it)

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US5833891A (en) * 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
WO1997045532A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair

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US6066340A (en) 2000-05-23
EP0517565B1 (en) 2000-10-18
GR3034789T3 (en) 2001-02-28
DE69231507T2 (de) 2001-05-03
CA2070095A1 (en) 1992-12-01
JPH07179363A (ja) 1995-07-18
ATE196991T1 (de) 2000-11-15
US6039970A (en) 2000-03-21
EP0979648A2 (en) 2000-02-16
ITPD910102A1 (it) 1992-12-01
ES2153355T3 (es) 2001-03-01
ITPD910102A0 (it) 1991-05-31
CA2070095C (en) 2000-04-25
EP0979648A3 (en) 2000-10-04
EP0517565A2 (en) 1992-12-09
EP0517565A3 (en) 1992-12-30
DE69231507D1 (de) 2000-11-23

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