HRP20141194T1 - Postupci lijeäśenja gihta - Google Patents

Postupci lijeäśenja gihta Download PDF

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Publication number
HRP20141194T1
HRP20141194T1 HRP20141194TT HRP20141194T HRP20141194T1 HR P20141194 T1 HRP20141194 T1 HR P20141194T1 HR P20141194T T HRP20141194T T HR P20141194TT HR P20141194 T HRP20141194 T HR P20141194T HR P20141194 T1 HRP20141194 T1 HR P20141194T1
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HR
Croatia
Prior art keywords
antibody
fragment
use according
binding fragment
administration
Prior art date
Application number
HRP20141194TT
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English (en)
Inventor
Alan M. Solinger
Original Assignee
Xoma (Us) Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Xoma (Us) Llc filed Critical Xoma (Us) Llc
Publication of HRP20141194T1 publication Critical patent/HRP20141194T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Claims (15)

1. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu u liječenju gihta, gdje protutijelo ili njegov fragment ima varijabilnu regiju lakog lanca prema SEQ ID NO: 5 i varijabilnu regiju teškog lanca prema SEQ ID NO:6.
2. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevu 1, gdje je to kronični ili akutni giht.
3. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevu 1-2, gdje se protutijelo ili fragment protutijela primjenjuje u jednoj ili više doza od 1 mg/kg ili manje protutijela ili fragmenta protutijela.
4. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevu 3, gdje je jedna ili više doza od barem 0,001 mg/kg protutijela ili fragmenta.
5. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-4, gdje se anti-IL-1β protutijelo ili fragment primjenjuje potkožnom, intravenskom ili intramuskularnom injekcijom.
6. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-5, gdje nakon primjene početne doze protutijela ili fragmenta protutijela slijedi primjena jedne ili više sljedećih doza.
7. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-5, gdje nakon primjene početne doze protutijela ili fragmenta protutijela slijedi primjena jedne ili više sljedećih doza, i gdje je ta jedna ili više sljedećih doza u količini koja je otprilike jednaka ili manja od početne doze.
8. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-5, gdje nakon primjene početne doze protutijela ili fragmenta protutijela slijedi primjena jedne ili više sljedećih doza, i gdje je barem jedna od tih sljedećih doza u količini većoj od početne doze.
9. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-8, gdje je doza protutijela ili fragmenta dovoljna za postizanje barem 50% smanjenja boli u zglobovima.
10. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-9, gdje je doza protutijela ili fragmenta dovoljna za postizanje barem 20% smanjenja razine C-reaktivnog proteina (CRP).
11. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-10, gdje je doza protutijela ili fragmenta dovoljna za postizanje barem 20% smanjenja sedimentacije eritrocita (ESR).
12. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-9, gdje je doza protutijela ili fragmenta dovoljna za postizanje barem 50% smanjenja boli u zglobovima, barem 20% smanjenja CRP i barem 20% smanjenja ESR.
13. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-12, gdje je taj postupak povezan s barem jednim dodatnim postupkom liječenja, taj dodatni postupak liječenja obuhvaća primjenu barem jednog farmaceutskog oblika koji sadrži djelatnu tvar koja nije IL-1β protutijelo ili fragment.
14. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevu 13, gdje se taj barem jedan farmaceutski oblik koji sadrži djelatnu tvar koja nije IL-1β protutijelo ili fragment izabire iz skupine koja obuhvaća nesteroidni protuupalni lijek (NSAID), kortikosteroid, adrenokortikotropni hormon i kolhicin.
15. Anti-IL-1β protutijelo ili njegov IL-1β-vezujući fragment za uporabu prema zahtjevima 1-14, gdje protutijelo ili njegov fragment ima niži IC50 od antagonista IL-1β receptora u testu inhibicije IL-1β u ljudskoj punoj krvi koji mjeri proizvodnju IL-8 induciranu od strane IL-1β.
HRP20141194TT 2007-12-20 2014-12-10 Postupci lijeäśenja gihta HRP20141194T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1563307P 2007-12-20 2007-12-20
US5937808P 2008-06-06 2008-06-06
US9519108P 2008-09-08 2008-09-08
PCT/US2008/087519 WO2009086003A1 (en) 2007-12-20 2008-12-18 Methods for the treatment of gout
EP08866346.3A EP2391650B1 (en) 2007-12-20 2008-12-18 Methods for the treatment of gout

Publications (1)

Publication Number Publication Date
HRP20141194T1 true HRP20141194T1 (hr) 2015-04-24

Family

ID=40529690

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20141194TT HRP20141194T1 (hr) 2007-12-20 2014-12-10 Postupci lijeäśenja gihta

Country Status (17)

Country Link
US (4) US8637029B2 (hr)
EP (2) EP2391650B1 (hr)
JP (1) JP5536666B2 (hr)
CN (1) CN101945891A (hr)
AU (1) AU2008343085B2 (hr)
CA (1) CA2710252C (hr)
CY (1) CY1115871T1 (hr)
DK (1) DK2391650T3 (hr)
ES (1) ES2527326T3 (hr)
HK (1) HK1208237A1 (hr)
HR (1) HRP20141194T1 (hr)
MX (1) MX2010006823A (hr)
PL (1) PL2391650T3 (hr)
PT (1) PT2391650E (hr)
RU (1) RU2018100129A (hr)
SI (1) SI2391650T1 (hr)
WO (1) WO2009086003A1 (hr)

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