RU2015134422A - Применение левоцитиризина и монтелукаста при лечении васкулита - Google Patents
Применение левоцитиризина и монтелукаста при лечении васкулита Download PDFInfo
- Publication number
- RU2015134422A RU2015134422A RU2015134422A RU2015134422A RU2015134422A RU 2015134422 A RU2015134422 A RU 2015134422A RU 2015134422 A RU2015134422 A RU 2015134422A RU 2015134422 A RU2015134422 A RU 2015134422A RU 2015134422 A RU2015134422 A RU 2015134422A
- Authority
- RU
- Russia
- Prior art keywords
- vasculitis
- active agent
- administered
- combination
- montelukast
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Claims (22)
1. Способ лечения васкулита у нуждающегося в этом пациента, включающий введение эффективного количества комбинации левоцетиризина и монтелукаста.
2. Способ по п. 1, отличающийся тем, что васкулит представляет собой васкулит мелких сосудов.
3. Способ по п. 1, отличающийся тем, что васкулит представляет собой васкулит средних сосудов.
4. Способ по п. 1, отличающийся тем, что васкулит представляет собой васкулит крупных сосудов.
5. Способ по п. 2, отличающийся тем, что васкулит мелких сосудов включает васкулит, ассоциируемый с антинейтрофильными цитоплазматическими антителами.
6. Способ по п. 2, отличающийся тем, что васкулит мелких сосудов включает васкулит, не ассоциируемый с антинейтрофильными цитоплазматическими антителами.
7. Способ по п. 1, отличающийся тем, что васкулит включает пурпуру Шенлейна-Геноха.
8. Способ по п. 1, отличающийся тем, что васкулит включает синдром Черджа-Стросс.
9. Способ по п. 1, отличающийся тем, что указанную комбинацию вводят последовательным образом.
10. Способ по п. 1, отличающийся тем, что указанную комбинацию вводят по существу одновременно.
11. Способ по п. 1, отличающийся тем, что указанную комбинацию вводят при возникновении симптомов.
12. Способ по п. 1, отличающийся тем, что указанную комбинацию вводят пациенту одним или более путей из группы, состоящей из энтерального, внутривенного, внутрибрюшинного, ингаляционного, внутримышечного, подкожного и перорального путей.
13. Способ по п. 1, отличающийся тем, что левоцитиризин и монтелукаст вводят одинаковым путем.
14. Способ по п. 1, отличающийся тем, что указанную комбинацию вводят при возникновении симптомов.
15. Способ по пп. 1-4, дополнительно включающий введение активного агента.
16. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой глюкокортикоид.
17. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой стероидный противовоспалительный агент.
18. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой нестероидный противовоспалительный агент.
19. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой антигистамин.
20. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой цитотоксическое лекарственное средство.
21. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой иммунодепрессивный агент.
22. Способ по п. 15, отличающийся тем, что указанный активный агент представляет собой моноклональное антитело.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361780380P | 2013-03-13 | 2013-03-13 | |
US61/780,380 | 2013-03-13 | ||
PCT/US2014/021723 WO2014164285A2 (en) | 2013-03-13 | 2014-03-07 | Use of levocetirizine and montelukast in the treatment of vasculitis |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2015134422A true RU2015134422A (ru) | 2017-04-18 |
Family
ID=51659295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015134422A RU2015134422A (ru) | 2013-03-13 | 2014-03-07 | Применение левоцитиризина и монтелукаста при лечении васкулита |
Country Status (10)
Country | Link |
---|---|
US (2) | US9669025B2 (ru) |
EP (1) | EP2968309A4 (ru) |
JP (1) | JP2016512262A (ru) |
KR (1) | KR20160125283A (ru) |
CN (1) | CN105263579B (ru) |
AU (1) | AU2014249534B2 (ru) |
CA (1) | CA2901413A1 (ru) |
MX (1) | MX2015011905A (ru) |
RU (1) | RU2015134422A (ru) |
WO (1) | WO2014164285A2 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2582373A4 (en) | 2010-06-16 | 2013-10-30 | Bruce Chandler May | USE OF LEVOCETIRIZIN AND MONTELUKAST IN THE TREATMENT OF INFLUENZA, COLLECTIONS AND INFLAMMATION |
ES2745041T3 (es) | 2013-03-13 | 2020-02-27 | Inflammatory Response Res Inc | Uso de levocetirizina y montelukast en el tratamiento de trastornos autoinmunitarios |
AU2014249534B2 (en) | 2013-03-13 | 2018-08-30 | IRR, Inc. | Use of levocetirizine and montelukast in the treatment of vasculitis |
RU2672871C2 (ru) | 2013-03-13 | 2018-11-20 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцетиризина и монтелукаста при лечении травматических повреждений |
EP3193875B1 (en) | 2014-09-15 | 2022-02-16 | Inflammatory Response Research, Inc. | Levocetirizine and montelukast in the treatment of inflammation mediated conditions |
EP3585809A4 (en) * | 2017-01-30 | 2021-02-24 | Western New England University | THIOLISOMERASE INHIBITORS AND USES THEREOF |
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RU2672871C2 (ru) | 2013-03-13 | 2018-11-20 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцетиризина и монтелукаста при лечении травматических повреждений |
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2014
- 2014-03-07 AU AU2014249534A patent/AU2014249534B2/en active Active
- 2014-03-07 KR KR1020157027767A patent/KR20160125283A/ko not_active Application Discontinuation
- 2014-03-07 JP JP2016500818A patent/JP2016512262A/ja active Pending
- 2014-03-07 CA CA2901413A patent/CA2901413A1/en not_active Abandoned
- 2014-03-07 EP EP14779115.6A patent/EP2968309A4/en not_active Withdrawn
- 2014-03-07 WO PCT/US2014/021723 patent/WO2014164285A2/en active Application Filing
- 2014-03-07 MX MX2015011905A patent/MX2015011905A/es unknown
- 2014-03-07 CN CN201480013797.7A patent/CN105263579B/zh active Active
- 2014-03-07 RU RU2015134422A patent/RU2015134422A/ru unknown
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2015
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2017
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AU2014249534B2 (en) | 2018-08-30 |
US10206919B2 (en) | 2019-02-19 |
WO2014164285A2 (en) | 2014-10-09 |
EP2968309A2 (en) | 2016-01-20 |
CA2901413A1 (en) | 2014-10-09 |
EP2968309A4 (en) | 2016-08-31 |
JP2016512262A (ja) | 2016-04-25 |
CN105263579B (zh) | 2020-01-10 |
AU2014249534A1 (en) | 2015-08-27 |
MX2015011905A (es) | 2016-01-08 |
KR20160125283A (ko) | 2016-10-31 |
CN105263579A (zh) | 2016-01-20 |
WO2014164285A3 (en) | 2015-10-29 |
US20150352101A1 (en) | 2015-12-10 |
US9669025B2 (en) | 2017-06-06 |
US20170231980A1 (en) | 2017-08-17 |
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