ATE196991T1 - Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospheren - Google Patents
Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospherenInfo
- Publication number
- ATE196991T1 ATE196991T1 AT92401433T AT92401433T ATE196991T1 AT E196991 T1 ATE196991 T1 AT E196991T1 AT 92401433 T AT92401433 T AT 92401433T AT 92401433 T AT92401433 T AT 92401433T AT E196991 T1 ATE196991 T1 AT E196991T1
- Authority
- AT
- Austria
- Prior art keywords
- biologically active
- active components
- microspheres containing
- containing biologically
- preparing microspheres
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE196991T1 true ATE196991T1 (de) | 2000-11-15 |
Family
ID=11389598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92401433T ATE196991T1 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospheren |
Country Status (9)
Country | Link |
---|---|
US (2) | US6066340A (de) |
EP (2) | EP0517565B1 (de) |
JP (1) | JPH07179363A (de) |
AT (1) | ATE196991T1 (de) |
CA (1) | CA2070095C (de) |
DE (1) | DE69231507T2 (de) |
ES (1) | ES2153355T3 (de) |
GR (1) | GR3034789T3 (de) |
IT (1) | IT1247472B (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
IT1263144B (it) * | 1993-02-04 | 1996-08-01 | Lanfranco Callegaro | Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive |
JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
AU695207B2 (en) * | 1995-03-28 | 1998-08-06 | Fidia Farmaceutici S.P.A. | Nanospheres comprising a biocompatible polysaccharide |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
US7276251B2 (en) * | 1997-04-01 | 2007-10-02 | Lg Life Sciences, Ltd., Inc. | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
AU3055099A (en) | 1998-05-20 | 1999-12-06 | Charna Chemicals Ltd. | A pharmaceutical formulation for nasal administration |
JP4610735B2 (ja) * | 1998-06-01 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | ワクチン抗原およびアジュバントの粘膜送達のためのヒアルロン酸ポリマーの使用 |
US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
JP2002537355A (ja) | 1999-02-26 | 2002-11-05 | カイロン コーポレイション | 抗原の粘膜送達のための生体接着剤およびアジュバントの使用 |
AU5624400A (en) * | 1999-06-18 | 2001-01-09 | Collaborative Group, Ltd., The | Hyaluronic acid film and matrix for sustained gene transfer |
US7582311B1 (en) * | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
GB0004827D0 (en) * | 2000-02-29 | 2000-04-19 | Quadrant Holdings Cambridge | Compositions |
US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
DE10064219B9 (de) * | 2000-12-22 | 2009-02-12 | Nasalis Pain Relief International Gmbh | Neue Fentanyl und/oder dessen Derivate enthaltende pharmazeutische Zusammensetzung zur nasalen Anwendung |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
DE60218375D1 (de) * | 2001-03-30 | 2007-04-12 | Chisso Corp | Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen |
FR2825273B1 (fr) * | 2001-05-29 | 2006-11-24 | Oreal | Composition pour le traitement des signes cutanes du vieillissement |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
US7276254B2 (en) * | 2002-05-07 | 2007-10-02 | Xerox Corporation | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same |
CA2486113A1 (en) * | 2002-05-17 | 2003-12-04 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
US20040197264A1 (en) * | 2003-04-04 | 2004-10-07 | Alexander Schwarz | Microspheres comprising therapeutic and diagnostic radioactive isotopes |
ES2226567B1 (es) * | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
ES2232287B1 (es) * | 2003-07-04 | 2006-11-01 | Advanced In Vitro Cell Technologies, S.L. | Nanoparticulas de derivados polioxietilenados. |
US8124120B2 (en) * | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
ES2246694B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
ES2246695B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
SI1899378T1 (sl) | 2005-06-21 | 2010-02-26 | Xoma Technology Ltd | IL-1Beta vezavna protitelesa in njihovi fragmenti |
EP3124045A3 (de) | 2006-12-20 | 2017-05-03 | Xoma (Us) Llc | Behandlung von il-1-beta-bedingten erkrankungen |
WO2008137747A1 (en) | 2007-05-02 | 2008-11-13 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
MX2010006823A (es) | 2007-12-20 | 2010-09-30 | Xoma Technology Ltd | Metodos para el tratamiento de la gota. |
ITMI20080981A1 (it) * | 2008-05-27 | 2009-11-28 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di microsfere di polimeri semi-sintetici |
EP2349209A2 (de) | 2008-09-26 | 2011-08-03 | Nanobio Corporation | Therapeutische zusammensetzungen in nanoemulsionsform und anwendungsverfahren dafür |
EP2376089B1 (de) | 2008-11-17 | 2018-03-14 | The Regents of the University of Michigan | Krebsvakzine-zusammensetzungen und anwendungsverfahren dafür |
ES2566646T3 (es) | 2009-06-16 | 2016-04-14 | The Regents Of The University Of Michigan | Vacunas en nanoemulsión |
US8658603B2 (en) | 2010-06-16 | 2014-02-25 | The Regents Of The University Of Michigan | Compositions and methods for inducing an immune response |
GB201017889D0 (en) * | 2010-10-22 | 2010-12-01 | Univ Dublin | A polymeric nanoparticle |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
JP2015509091A (ja) | 2012-01-09 | 2015-03-26 | ザ スクリプス リサーチ インスティテュート | ヒト化抗体 |
CA2863224A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
US9687573B2 (en) | 2013-03-13 | 2017-06-27 | Biosphere Medical, Inc. | Compositions and associated methods for radioisotope-binding microparticles |
WO2015017146A2 (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
CN111518199A (zh) | 2013-07-18 | 2020-08-11 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
ES2845924T3 (es) | 2013-10-15 | 2021-07-28 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos peptídicos y usos de los mismos |
WO2015057852A1 (en) | 2013-10-15 | 2015-04-23 | The California Institute For Biomedical Research | Chimeric antigen receptor t cell switches and uses thereof |
US10208102B2 (en) | 2013-11-01 | 2019-02-19 | University Of Oslo | Albumin variants and uses thereof |
DK3069138T3 (en) | 2013-11-15 | 2019-04-08 | Univ Oslo Hf | CTL PEPTID EPITOPES AND ANTIGEN-SPECIFIC T-CELLS, METHODS OF RECOGNITION THEREOF, AND APPLICATIONS THEREOF |
CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
WO2016057921A1 (en) | 2014-10-10 | 2016-04-14 | Baker Jr James R | Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease |
WO2016141320A2 (en) | 2015-03-05 | 2016-09-09 | Northwestern University | Non-neuroinvasive viruses and uses thereof |
WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
US11091546B2 (en) | 2015-04-15 | 2021-08-17 | The Scripps Research Institute | Optimized PNE-based chimeric receptor T cell switches and uses thereof |
US20190000928A1 (en) | 2015-06-17 | 2019-01-03 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
WO2016207730A1 (en) | 2015-06-22 | 2016-12-29 | The University Of Oslo | Targeting of vaccine antigen to an intracellular compartment |
CN105663052B (zh) * | 2016-02-05 | 2019-03-15 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子缓释微球制剂及其制备方法 |
WO2017201390A1 (en) | 2016-05-19 | 2017-11-23 | The Regents Of The University Of Michigan | Novel adjuvant compositions |
WO2018075807A1 (en) | 2016-10-19 | 2018-04-26 | California Institute For Biomedical Research | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
JP2020533338A (ja) | 2017-09-07 | 2020-11-19 | ユニバーシティ オブ オスロUniversity of Oslo | ワクチン分子 |
US12005112B2 (en) | 2017-09-07 | 2024-06-11 | University Of Oslo | Vaccine molecules |
CA3149494A1 (en) | 2019-08-12 | 2021-02-18 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
WO2021081440A2 (en) | 2019-10-24 | 2021-04-29 | Minotaur Therapeutics, Inc. | Chimeric cytokine modified antibodies and methods of use thereof |
KR102296304B1 (ko) | 2020-11-30 | 2021-09-01 | 조광용 | 고팽윤성 히알루론산 비드 겔 제조 방법 |
KR102366394B1 (ko) | 2021-01-05 | 2022-02-23 | 조광용 | 고팽윤성 히알루론산 비드 겔 |
US20240156935A1 (en) | 2021-03-31 | 2024-05-16 | Vib Vzw | Vaccine Compositions for Trypanosomatids |
JP2024517759A (ja) | 2021-04-28 | 2024-04-23 | ミノトール セラピューティクス インコーポレイテッド | ヒト化キメラウシ抗体および使用方法 |
Family Cites Families (28)
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DE2750090A1 (de) * | 1976-11-19 | 1978-06-01 | Sandoz Ag | Neue verabreichungsformen fuer organische verbindungen |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
SE8501022L (sv) | 1985-03-01 | 1986-09-02 | Pharmacia Ab | Format alster och forfarande for dess framstellning |
US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
WO1987003197A1 (en) * | 1985-11-29 | 1987-06-04 | Fisons Plc | Pharmaceutical composition including sodium cromoglycate |
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US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
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JP2876058B2 (ja) * | 1986-08-18 | 1999-03-31 | エミスフィア・テクノロジーズ・インコーポレイテッド | 薬物送達システム |
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
US5108759A (en) * | 1987-04-01 | 1992-04-28 | Ranney David F | Endothelial envelopment drug carriers |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
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JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
US5879359A (en) * | 1992-08-03 | 1999-03-09 | Fidia S.P.A. | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids |
IT1268955B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Esteri attivi di polisaccaridi carbossilici |
US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US5939323A (en) * | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
-
1991
- 1991-05-31 IT ITPD910102A patent/IT1247472B/it active IP Right Grant
-
1992
- 1992-05-26 EP EP92401433A patent/EP0517565B1/de not_active Expired - Lifetime
- 1992-05-26 EP EP99202579A patent/EP0979648A3/de not_active Withdrawn
- 1992-05-26 ES ES92401433T patent/ES2153355T3/es not_active Expired - Lifetime
- 1992-05-26 AT AT92401433T patent/ATE196991T1/de not_active IP Right Cessation
- 1992-05-26 DE DE69231507T patent/DE69231507T2/de not_active Expired - Lifetime
- 1992-05-29 JP JP4139012A patent/JPH07179363A/ja active Pending
- 1992-05-29 CA CA002070095A patent/CA2070095C/en not_active Expired - Lifetime
-
1993
- 1993-12-20 US US08/169,558 patent/US6066340A/en not_active Expired - Lifetime
-
1999
- 1999-01-13 US US09/231,353 patent/US6039970A/en not_active Expired - Lifetime
-
2000
- 2000-11-08 GR GR20000402482T patent/GR3034789T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3034789T3 (en) | 2001-02-28 |
EP0517565B1 (de) | 2000-10-18 |
US6039970A (en) | 2000-03-21 |
EP0979648A3 (de) | 2000-10-04 |
CA2070095C (en) | 2000-04-25 |
ES2153355T3 (es) | 2001-03-01 |
IT1247472B (it) | 1994-12-17 |
JPH07179363A (ja) | 1995-07-18 |
ITPD910102A0 (it) | 1991-05-31 |
EP0979648A2 (de) | 2000-02-16 |
DE69231507D1 (de) | 2000-11-23 |
CA2070095A1 (en) | 1992-12-01 |
DE69231507T2 (de) | 2001-05-03 |
EP0517565A3 (en) | 1992-12-30 |
EP0517565A2 (de) | 1992-12-09 |
US6066340A (en) | 2000-05-23 |
ITPD910102A1 (it) | 1992-12-01 |
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