DE69005800T2 - Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen. - Google Patents

Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.

Info

Publication number
DE69005800T2
DE69005800T2 DE69005800T DE69005800T DE69005800T2 DE 69005800 T2 DE69005800 T2 DE 69005800T2 DE 69005800 T DE69005800 T DE 69005800T DE 69005800 T DE69005800 T DE 69005800T DE 69005800 T2 DE69005800 T2 DE 69005800T2
Authority
DE
Germany
Prior art keywords
molecules
biologically active
particles
active molecules
small particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69005800T
Other languages
English (en)
Other versions
DE69005800D1 (de
Inventor
Wayne Gombotz
Michael Healy
Larry Brown
Henry Auer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Publication of DE69005800D1 publication Critical patent/DE69005800D1/de
Application granted granted Critical
Publication of DE69005800T2 publication Critical patent/DE69005800T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
DE69005800T 1989-05-01 1990-05-01 Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen. Expired - Lifetime DE69005800T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34568489A 1989-05-01 1989-05-01
PCT/US1990/002421 WO1990013285A1 (en) 1989-05-01 1990-05-01 Process for producing small particles of biologically active molecules

Publications (2)

Publication Number Publication Date
DE69005800D1 DE69005800D1 (de) 1994-02-17
DE69005800T2 true DE69005800T2 (de) 1994-05-19

Family

ID=23356054

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69005800T Expired - Lifetime DE69005800T2 (de) 1989-05-01 1990-05-01 Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.

Country Status (10)

Country Link
US (1) US6569458B1 (de)
EP (1) EP0432232B1 (de)
JP (1) JPH0739339B2 (de)
AT (1) ATE99546T1 (de)
AU (1) AU620253B2 (de)
CA (1) CA2030551C (de)
DE (1) DE69005800T2 (de)
DK (1) DK0432232T3 (de)
ES (1) ES2062530T3 (de)
WO (1) WO1990013285A1 (de)

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WO1990013285A1 (en) 1990-11-15
CA2030551C (en) 1998-08-25
ATE99546T1 (de) 1994-01-15
DE69005800D1 (de) 1994-02-17
EP0432232B1 (de) 1994-01-05
JPH0739339B2 (ja) 1995-05-01
US6569458B1 (en) 2003-05-27
AU5635990A (en) 1990-11-29
DK0432232T3 (da) 1994-01-31
AU620253B2 (en) 1992-02-13
CA2030551A1 (en) 1990-11-02
JPH04500527A (ja) 1992-01-30
EP0432232A1 (de) 1991-06-19
ES2062530T3 (es) 1994-12-16

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