DE69634043D1 - Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie - Google Patents

Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

Info

Publication number
DE69634043D1
DE69634043D1 DE69634043T DE69634043T DE69634043D1 DE 69634043 D1 DE69634043 D1 DE 69634043D1 DE 69634043 T DE69634043 T DE 69634043T DE 69634043 T DE69634043 T DE 69634043T DE 69634043 D1 DE69634043 D1 DE 69634043D1
Authority
DE
Germany
Prior art keywords
circular dna
genetherapy
manufacturing process
dna molecular
reaction treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634043T
Other languages
English (en)
Other versions
DE69634043T2 (de
Inventor
Joel Crouzet
Fabienne Soubrier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTELION, VITRY SUR SEINE, FR
Original Assignee
Gencell SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9482580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69634043(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gencell SAS filed Critical Gencell SAS
Publication of DE69634043D1 publication Critical patent/DE69634043D1/de
Application granted granted Critical
Publication of DE69634043T2 publication Critical patent/DE69634043T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • C07K14/501—Fibroblast growth factors [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
DE69634043T 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie Expired - Lifetime DE69634043T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9510825 1995-09-15
FR9510825A FR2738842B1 (fr) 1995-09-15 1995-09-15 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
PCT/FR1996/001414 WO1997010343A1 (fr) 1995-09-15 1996-09-13 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique

Publications (2)

Publication Number Publication Date
DE69634043D1 true DE69634043D1 (de) 2005-01-20
DE69634043T2 DE69634043T2 (de) 2005-08-18

Family

ID=9482580

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69634043T Expired - Lifetime DE69634043T2 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie
DE69636878T Expired - Lifetime DE69636878T2 (de) 1995-09-15 1996-09-13 Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie
DE69638314T Expired - Lifetime DE69638314D1 (de) 1995-09-15 1996-09-13 Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69636878T Expired - Lifetime DE69636878T2 (de) 1995-09-15 1996-09-13 Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie
DE69638314T Expired - Lifetime DE69638314D1 (de) 1995-09-15 1996-09-13 Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie

Country Status (20)

Country Link
US (3) US6977174B2 (de)
EP (3) EP0850310B1 (de)
JP (3) JP3818665B2 (de)
KR (1) KR100522369B1 (de)
AT (3) ATE352630T1 (de)
BR (1) BRPI9610511B8 (de)
CA (1) CA2229307C (de)
CZ (1) CZ294525B6 (de)
DE (3) DE69634043T2 (de)
DK (3) DK0850310T3 (de)
ES (3) ES2281721T3 (de)
FR (1) FR2738842B1 (de)
HU (1) HU224400B1 (de)
IL (4) IL123641A0 (de)
NO (1) NO323975B1 (de)
PT (3) PT1724354E (de)
SK (1) SK285317B6 (de)
TW (1) TWI231826B (de)
WO (1) WO1997010343A1 (de)
ZA (1) ZA967640B (de)

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US7279313B2 (en) * 1995-09-15 2007-10-09 Centelion Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
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US6821759B1 (en) 1997-06-23 2004-11-23 The Rockefeller University Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof
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Also Published As

Publication number Publication date
DE69634043T2 (de) 2005-08-18
WO1997010343A1 (fr) 1997-03-20
EP1724354B1 (de) 2010-12-22
PT850310E (pt) 2005-05-31
HU224400B1 (hu) 2005-08-29
EP1724354A3 (de) 2008-10-29
JP2006136328A (ja) 2006-06-01
ES2281721T3 (es) 2007-10-01
EP0850310A1 (de) 1998-07-01
PT1508620E (pt) 2007-05-31
SK285317B6 (sk) 2006-10-05
IL123641A (en) 2006-06-11
ES2233975T3 (es) 2005-06-16
US20090149406A1 (en) 2009-06-11
AU6992496A (en) 1997-04-01
US6977174B2 (en) 2005-12-20
DE69638314D1 (de) 2011-02-03
FR2738842B1 (fr) 1997-10-31
EP1724354A2 (de) 2006-11-22
JP3818665B2 (ja) 2006-09-06
HUP9900018A3 (en) 2001-10-29
EP1508620B1 (de) 2007-01-24
US20010014476A1 (en) 2001-08-16
CA2229307A1 (fr) 1997-03-20
JP4585435B2 (ja) 2010-11-24
DK0850310T3 (da) 2005-04-25
CA2229307C (fr) 2013-06-11
JP2007325603A (ja) 2007-12-20
MX9802005A (es) 1998-08-30
DK1724354T3 (da) 2011-04-04
BR9610511B1 (pt) 2010-10-19
JP2000501281A (ja) 2000-02-08
SK34798A3 (en) 1998-11-04
DE69636878T2 (de) 2007-11-08
BR9610511A (pt) 1999-01-26
DK1508620T3 (da) 2007-05-29
US20090130674A1 (en) 2009-05-21
KR100522369B1 (ko) 2006-10-24
ATE284966T1 (de) 2005-01-15
IL207348A0 (en) 2010-12-30
NO981044L (no) 1998-03-10
ATE352630T1 (de) 2007-02-15
ATE492642T1 (de) 2011-01-15
KR19990044683A (ko) 1999-06-25
IL123641A0 (en) 1998-10-30
EP1508620A1 (de) 2005-02-23
FR2738842A1 (fr) 1997-03-21
JP4756014B2 (ja) 2011-08-24
NO981044D0 (no) 1998-03-10
EP0850310B1 (de) 2004-12-15
AU728231B2 (en) 2001-01-04
CZ294525B6 (cs) 2005-01-12
CZ78898A3 (cs) 1998-06-17
ES2357098T3 (es) 2011-04-18
BRPI9610511B8 (pt) 2016-11-08
DE69636878D1 (de) 2007-03-15
PT1724354E (pt) 2011-03-09
TWI231826B (en) 2005-05-01
NO323975B1 (no) 2007-07-30
ZA967640B (en) 1997-03-25
HUP9900018A1 (hu) 1999-04-28
IL173399A (en) 2010-11-30
IL173399A0 (en) 2006-06-11

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