ATE188740T1 - Viruspartikel mit veraendertem wirtspektrum - Google Patents
Viruspartikel mit veraendertem wirtspektrumInfo
- Publication number
- ATE188740T1 ATE188740T1 AT91915104T AT91915104T ATE188740T1 AT E188740 T1 ATE188740 T1 AT E188740T1 AT 91915104 T AT91915104 T AT 91915104T AT 91915104 T AT91915104 T AT 91915104T AT E188740 T1 ATE188740 T1 AT E188740T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- altered host
- incorporation
- virus particles
- disclosed
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 2
- 238000001228 spectrum Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 241000713869 Moloney murine leukemia virus Species 0.000 abstract 2
- 238000010348 incorporation Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13051—Methods of production or purification of viral material
- C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13061—Methods of inactivation or attenuation
- C12N2740/13062—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65863291A | 1991-02-19 | 1991-02-19 | |
| PCT/US1991/005699 WO1992014829A1 (en) | 1991-02-19 | 1991-08-09 | Viral particles having altered host range |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188740T1 true ATE188740T1 (de) | 2000-01-15 |
Family
ID=24642035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91915104T ATE188740T1 (de) | 1991-02-19 | 1991-08-09 | Viruspartikel mit veraendertem wirtspektrum |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0572401B2 (de) |
| JP (1) | JP3547129B2 (de) |
| AT (1) | ATE188740T1 (de) |
| CA (1) | CA2104396C (de) |
| DE (1) | DE69131908T3 (de) |
| WO (1) | WO1992014829A1 (de) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512421A (en) * | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| WO1993020221A1 (en) * | 1992-04-03 | 1993-10-14 | Young Alexander T | Gene therapy using targeted viral vectors |
| AU689755B2 (en) * | 1992-09-22 | 1998-04-09 | Biofocus Discovery Limited | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| ATE263252T1 (de) * | 1992-11-09 | 2004-04-15 | Us Health | Erzielbare vektorenpartikel |
| JPH09503656A (ja) * | 1993-09-03 | 1997-04-15 | チロン ビアジーン インコーポレイティド | 移植片拒絶の抑制方法 |
| AU3635695A (en) * | 1994-09-19 | 1996-04-09 | Board Of Trustees Of The Leland Stanford Junior University | Methods for genetically modifying hematopoietic stem cells |
| US5871986A (en) | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US6818439B1 (en) | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
| US5681746A (en) * | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US6117681A (en) * | 1995-03-29 | 2000-09-12 | Bavarian Nordic Research Inst. A/S | Pseudotyped retroviral particles |
| US5750396A (en) * | 1995-05-08 | 1998-05-12 | St. Judes Children's Research Hospital | Stable virus packaging cell lines |
| AU7470096A (en) * | 1995-10-05 | 1997-04-28 | Chiron Corporation | Retroviral vectors pseudotyped with srv-3 envelope glycoprotein sequences |
| US5910434A (en) * | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| US6723531B2 (en) | 1996-04-05 | 2004-04-20 | The Salk Institute For Biological Studies | Method for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| US5928638A (en) * | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
| US6133027A (en) * | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
| US5739018A (en) * | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
| US6183993B1 (en) | 1996-09-11 | 2001-02-06 | The General Hospital Corporation | Complement-resistant non-mammalian DNA viruses and uses thereof |
| WO1998012311A2 (en) | 1996-09-11 | 1998-03-26 | The General Hospital Corporation | Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell |
| BR9712978A (pt) | 1996-09-11 | 2000-04-18 | Gen Hospital Corp | Vìrus de dna de não-mamìferos possuindo uma proteìna de revestimento alterada |
| US6818209B1 (en) | 1998-05-22 | 2004-11-16 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
| US6300488B1 (en) | 1997-07-10 | 2001-10-09 | The Salk Institute For Biological Studies | Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression |
| US7078483B2 (en) | 1998-04-29 | 2006-07-18 | University Of Southern California | Retroviral vectors including modified envelope escort proteins |
| US6333318B1 (en) | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| ATE435297T1 (de) * | 1998-05-22 | 2009-07-15 | Oxford Biomedica Ltd | Retrovirales verabreichungssystem |
| AU5122499A (en) | 1998-07-27 | 2000-02-21 | Genentech Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US7504253B2 (en) | 1999-06-11 | 2009-03-17 | The Burnham Institute For Medical Research | Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof |
| US7057015B1 (en) | 1999-10-20 | 2006-06-06 | The Salk Institute For Biological Studies | Hormone receptor functional dimers and methods of their use |
| US6864085B2 (en) | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
| US7335646B2 (en) | 2000-03-13 | 2008-02-26 | Engene, Inc. | Compositions and methods for regulated protein expression in gut |
| US6656718B2 (en) | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
| EP1373536B9 (de) | 2001-03-13 | 2009-09-02 | Novartis AG | Lentivirale verpackungskonstrukte |
| CA2524619A1 (en) | 2005-11-22 | 2007-05-22 | Ottawa Health Research Institute | Novel stem cells, nucleotide sequences and proteins therefrom |
| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類cd134(ox40)之人類單株抗體及其製造及使用方法 |
| CA2683287A1 (en) | 2006-11-27 | 2008-12-18 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
| CA2677273A1 (en) | 2007-02-06 | 2008-08-14 | Tai-June Yoo | Use of a composition comprising a cytokine encoding nucleic acid for treating alzheimer's disease |
| EP2537522A1 (de) | 2007-08-02 | 2012-12-26 | California Stem Cell, Inc. | Neuronale Vorläuferzellen und Verfahren zur Ableitung und Reinigung neuronaler Vorläuferzellen aus embryonischen Stammzellen |
| EP2215231A4 (de) | 2007-10-15 | 2010-12-01 | Univ Queensland | Expressionssystem zur modulation einer immunantwort |
| AU2008323853B8 (en) | 2007-11-08 | 2014-07-24 | Beth Israel Deaconess Medical Center | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-CD3/CD28 |
| US8877896B2 (en) | 2008-02-15 | 2014-11-04 | Tufts University | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders |
| AU2009215118B2 (en) | 2008-02-15 | 2015-01-22 | Tufts University | A humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration |
| DK3192874T3 (da) | 2008-06-18 | 2019-12-16 | Oxford Biomedica Ltd | Virusoprensning |
| US8999919B2 (en) | 2008-10-22 | 2015-04-07 | Trustees Of Dartmouth College | Compositions and methods for inhibiting the interaction between CFTR and CAL |
| US8211487B2 (en) | 2008-11-26 | 2012-07-03 | Srinivasan Damodaran | Inhibition of ice crystal growth |
| WO2010117057A1 (ja) | 2009-04-10 | 2010-10-14 | 協和発酵キリン株式会社 | 抗tim-3抗体を用いた血液腫瘍治療法 |
| PT2426148E (pt) | 2009-04-27 | 2015-10-26 | Kyowa Hakko Kirin Co Ltd | Anticorpo anti-rá-il-3 para se utilizar no tratamento de tumores do sangue |
| WO2011060233A1 (en) | 2009-11-11 | 2011-05-19 | The Trustees Of The University Of Pennsylvania | Anti-tem1 antibodies and uses thereof |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| CA2843684A1 (en) | 2010-08-13 | 2012-02-16 | Tufts University | Compositions, kits and methods for treatment of macular degeneration using soluble membrane-independent cd59 protein |
| WO2013040517A2 (en) | 2011-09-15 | 2013-03-21 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH |
| US9783610B2 (en) | 2012-04-27 | 2017-10-10 | The Trustees Of The University Of Pennsylvania | Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof |
| EP2953970A4 (de) | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | Transthyretinantikörper und verwendungen davon |
| EP3003393A4 (de) | 2013-06-04 | 2017-01-11 | The Johns Hopkins University | Dreiteilige theranostische krebs-nukleinsäurekonstrukte |
| WO2014197599A1 (en) | 2013-06-04 | 2014-12-11 | The Johns Hopkins University | Peg-prom mediated surface expression of avidin/streptavidin |
| EP3004153B1 (de) | 2013-06-04 | 2019-10-30 | Virginia Commonwealth University | Rekombinantes cytokin für eine krebstherapie |
| WO2014197586A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
| EP3003022B1 (de) | 2013-06-04 | 2017-11-22 | Virginia Commonwealth University | Verwendung eines trunkierten ccn1-promotors für krebsdiagnostik, therapeutika und theranostika |
| US20160152952A1 (en) | 2013-06-25 | 2016-06-02 | Temple University-Of The Commonwealth System Of Higher Education | Cortical Bone-Derived Stem Cells |
| ES2872537T3 (es) | 2014-08-28 | 2021-11-02 | Univ Tufts | Composiciones, métodos y kits para el tratamiento de trastornos relacionados con el complemento |
| US9901639B2 (en) | 2015-02-13 | 2018-02-27 | Temple University—Of the Commonwealth System of Higher Education | Bone marrow origin progenitor cell or endothelial progenitor cell in combination with DNMT1 gene therapy for vascular repair in metabolic disease |
| CN105372433A (zh) * | 2015-08-21 | 2016-03-02 | 深圳出入境检验检疫局动植物检验检疫技术中心 | 一种水泡性口炎病毒抗体快速检测试纸条 |
| US10149887B2 (en) | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| KR102895580B1 (ko) | 2015-12-09 | 2025-12-03 | 진강 메디신 (오스트레일리아) 피티와이 엘티디 | 치료를 위한 면역조절용 조성물 |
| AU2017250191A1 (en) | 2016-04-13 | 2018-11-08 | Orimabs Ltd. | Anti-PSMA antibodies and use thereof |
| EP3299460A1 (de) | 2016-09-26 | 2018-03-28 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Neuartige verbindungen und verfahren zur modulation der ubiquitinierung |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| JP2020531514A (ja) | 2017-08-22 | 2020-11-05 | モナシュ・ユニヴァーシティ | 終末糖化産物受容体(rage)の活性化のスクリーニングアッセイ、モジュレーター及び調節 |
| CA3090997A1 (en) | 2018-02-12 | 2019-08-15 | Trustees Of Tufts College | Cd59 for inhibiting inflammasome activation |
| US12233135B2 (en) | 2018-04-11 | 2025-02-25 | Precision Molecular Inc. | Therapeutic constructs for treating cancer |
| US12098212B2 (en) | 2019-08-12 | 2024-09-24 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells |
| TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| EP4413038A1 (de) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1-bindende affimere |
| EP4412711A1 (de) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Serumhalbwertszeiterweiterte pd-l1-bindende polypeptide |
| CN118369333A (zh) | 2021-11-19 | 2024-07-19 | 詹森生物科技公司 | 用表达可溶性cd59的基因疗法载体治疗地图样萎缩的方法 |
| EP4514389A1 (de) | 2022-04-29 | 2025-03-05 | Purinomia Biotech, Inc. | Verfahren und zusammensetzungen zur behandlung von eosinophil-bedingten erkrankungen und störungen |
| WO2025074268A1 (en) | 2023-10-02 | 2025-04-10 | Janssen Biotech, Inc. | Methods for treating macular degeneration |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
| FR2619012B1 (fr) * | 1987-08-07 | 1989-12-22 | Pasteur Institut | Vaccins dont l'epitope caracteristique est incorpore dans une proteine de picornavirus, notamment de poliovirus |
| WO1990005538A1 (en) * | 1988-11-14 | 1990-05-31 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Parvovirus capsids |
| JPH04504361A (ja) * | 1989-04-05 | 1992-08-06 | ノバセル コーポレイション | 感染性標的化複製―欠陥ビリオン |
| AU5848390A (en) * | 1989-06-01 | 1991-01-07 | Applied Biotechnology, Inc. | Self-assembled, defective, non-self-propagating viral particles |
| AU5642690A (en) * | 1989-08-21 | 1991-04-03 | Hans-Peter Brackmann | Portable device for the acquisition of data concerning therapy-relevant events |
| WO1991006658A2 (en) * | 1989-10-24 | 1991-05-16 | Cetus Corporation | Infective protein delivery system |
-
1991
- 1991-08-09 AT AT91915104T patent/ATE188740T1/de not_active IP Right Cessation
- 1991-08-09 EP EP91915104A patent/EP0572401B2/de not_active Expired - Lifetime
- 1991-08-09 CA CA002104396A patent/CA2104396C/en not_active Expired - Lifetime
- 1991-08-09 DE DE69131908T patent/DE69131908T3/de not_active Expired - Lifetime
- 1991-08-09 WO PCT/US1991/005699 patent/WO1992014829A1/en not_active Ceased
- 1991-08-09 JP JP51451891A patent/JP3547129B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69131908T3 (de) | 2008-04-03 |
| CA2104396A1 (en) | 1992-08-20 |
| JPH06504905A (ja) | 1994-06-09 |
| EP0572401A1 (de) | 1993-12-08 |
| EP0572401B1 (de) | 2000-01-12 |
| AU663470B2 (en) | 1995-10-12 |
| DE69131908T2 (de) | 2000-08-17 |
| CA2104396C (en) | 2000-10-10 |
| WO1992014829A1 (en) | 1992-09-03 |
| DE69131908D1 (de) | 2000-02-17 |
| JP3547129B2 (ja) | 2004-07-28 |
| AU8430291A (en) | 1992-09-15 |
| EP0572401B2 (de) | 2007-11-07 |
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