DK0850310T3 - Cirkulært DNA molekyle med betinget replikationsorigin, proces til fremstilling deraf og anvendelse deraf i genterapi - Google Patents

Cirkulært DNA molekyle med betinget replikationsorigin, proces til fremstilling deraf og anvendelse deraf i genterapi

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Publication number
DK0850310T3
DK0850310T3 DK96931124T DK96931124T DK0850310T3 DK 0850310 T3 DK0850310 T3 DK 0850310T3 DK 96931124 T DK96931124 T DK 96931124T DK 96931124 T DK96931124 T DK 96931124T DK 0850310 T3 DK0850310 T3 DK 0850310T3
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Denmark
Prior art keywords
replication
gene therapy
dna molecule
circular dna
preparation
Prior art date
Application number
DK96931124T
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English (en)
Inventor
Joeel Crouzet
Fabienne Soubrier
Original Assignee
Centelion
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Application filed by Centelion filed Critical Centelion
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Publication of DK0850310T3 publication Critical patent/DK0850310T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
DK96931124T 1995-09-15 1996-09-13 Cirkulært DNA molekyle med betinget replikationsorigin, proces til fremstilling deraf og anvendelse deraf i genterapi DK0850310T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9510825A FR2738842B1 (fr) 1995-09-15 1995-09-15 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
PCT/FR1996/001414 WO1997010343A1 (fr) 1995-09-15 1996-09-13 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
EP96931124A EP0850310B1 (fr) 1995-09-15 1996-09-13 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique

Publications (1)

Publication Number Publication Date
DK0850310T3 true DK0850310T3 (da) 2005-04-25

Family

ID=9482580

Family Applications (3)

Application Number Title Priority Date Filing Date
DK04016978T DK1508620T3 (da) 1995-09-15 1996-09-13 Cirkulært DNA-molekyle med konditionelt replikationsorigin, fremgangsmåder til fremstilling heraf og anvendelse heraf i genterapi
DK06017245.9T DK1724354T3 (da) 1995-09-15 1996-09-13 Cirkulær DNA-molekyle med en afhængig replikationsoprindelse, fremgangsmåde til fremstilling heraf og anvendelse heraf i genterapi
DK96931124T DK0850310T3 (da) 1995-09-15 1996-09-13 Cirkulært DNA molekyle med betinget replikationsorigin, proces til fremstilling deraf og anvendelse deraf i genterapi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK04016978T DK1508620T3 (da) 1995-09-15 1996-09-13 Cirkulært DNA-molekyle med konditionelt replikationsorigin, fremgangsmåder til fremstilling heraf og anvendelse heraf i genterapi
DK06017245.9T DK1724354T3 (da) 1995-09-15 1996-09-13 Cirkulær DNA-molekyle med en afhængig replikationsoprindelse, fremgangsmåde til fremstilling heraf og anvendelse heraf i genterapi

Country Status (20)

Country Link
US (3) US6977174B2 (da)
EP (3) EP1724354B1 (da)
JP (3) JP3818665B2 (da)
KR (1) KR100522369B1 (da)
AT (3) ATE284966T1 (da)
BR (1) BRPI9610511B8 (da)
CA (1) CA2229307C (da)
CZ (1) CZ294525B6 (da)
DE (3) DE69636878T2 (da)
DK (3) DK1508620T3 (da)
ES (3) ES2233975T3 (da)
FR (1) FR2738842B1 (da)
HU (1) HU224400B1 (da)
IL (4) IL123641A0 (da)
NO (1) NO323975B1 (da)
PT (3) PT1724354E (da)
SK (1) SK285317B6 (da)
TW (1) TWI231826B (da)
WO (1) WO1997010343A1 (da)
ZA (1) ZA967640B (da)

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ES2703341T3 (es) * 2013-03-14 2019-03-08 Genvivo Inc Ensayo diagnóstico de timidina quinasa para aplicaciones de terapia génica
DK3456821T4 (da) 2017-09-19 2024-04-15 Deutsches Krebsforsch Ikke-integrerende dna-vektorer til genetisk modifikation af celler
WO2019057774A1 (en) 2017-09-19 2019-03-28 Deutsches Krebsforschungszentrum NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS
JP2021518150A (ja) 2018-03-21 2021-08-02 ネイチャー テクノロジー コーポレーション 生成が改良されたウイルス及び非ウイルスのナノプラスミドベクター
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FR2738842B1 (fr) * 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
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Publication number Publication date
DE69636878D1 (de) 2007-03-15
MX9802005A (es) 1998-08-30
FR2738842B1 (fr) 1997-10-31
EP1724354A3 (fr) 2008-10-29
JP2007325603A (ja) 2007-12-20
US20010014476A1 (en) 2001-08-16
CA2229307C (fr) 2013-06-11
HUP9900018A3 (en) 2001-10-29
JP3818665B2 (ja) 2006-09-06
PT850310E (pt) 2005-05-31
PT1724354E (pt) 2011-03-09
FR2738842A1 (fr) 1997-03-21
DE69636878T2 (de) 2007-11-08
ZA967640B (en) 1997-03-25
JP2006136328A (ja) 2006-06-01
EP0850310A1 (fr) 1998-07-01
BR9610511A (pt) 1999-01-26
EP1508620A1 (fr) 2005-02-23
IL123641A0 (en) 1998-10-30
AU6992496A (en) 1997-04-01
EP1724354B1 (fr) 2010-12-22
SK34798A3 (en) 1998-11-04
ES2233975T3 (es) 2005-06-16
ATE352630T1 (de) 2007-02-15
US6977174B2 (en) 2005-12-20
IL123641A (en) 2006-06-11
SK285317B6 (sk) 2006-10-05
PT1508620E (pt) 2007-05-31
WO1997010343A1 (fr) 1997-03-20
HUP9900018A1 (hu) 1999-04-28
EP1508620B1 (fr) 2007-01-24
NO981044L (no) 1998-03-10
ES2281721T3 (es) 2007-10-01
EP0850310B1 (fr) 2004-12-15
KR19990044683A (ko) 1999-06-25
DK1508620T3 (da) 2007-05-29
EP1724354A2 (fr) 2006-11-22
ES2357098T3 (es) 2011-04-18
BRPI9610511B8 (pt) 2016-11-08
AU728231B2 (en) 2001-01-04
NO981044D0 (no) 1998-03-10
HU224400B1 (hu) 2005-08-29
DE69634043D1 (de) 2005-01-20
US20090149406A1 (en) 2009-06-11
DK1724354T3 (da) 2011-04-04
BR9610511B1 (pt) 2010-10-19
JP2000501281A (ja) 2000-02-08
IL173399A0 (en) 2006-06-11
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JP4756014B2 (ja) 2011-08-24
ATE492642T1 (de) 2011-01-15
CZ78898A3 (cs) 1998-06-17
US20090130674A1 (en) 2009-05-21
CA2229307A1 (fr) 1997-03-20
ATE284966T1 (de) 2005-01-15
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