MX2007013356A - Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas. - Google Patents
Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas.Info
- Publication number
- MX2007013356A MX2007013356A MX2007013356A MX2007013356A MX2007013356A MX 2007013356 A MX2007013356 A MX 2007013356A MX 2007013356 A MX2007013356 A MX 2007013356A MX 2007013356 A MX2007013356 A MX 2007013356A MX 2007013356 A MX2007013356 A MX 2007013356A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- preformed
- modified microparticles
- forming
- same
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Glanulating (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Se describen microparticulas modificadas en la superficie y metodos para elaborar y utilizar dichas particulas. Las microparticulas modificadas en la superficie incluyen una microparticula preformada o de nucleo que contiene al menos un agente activo. La superficie externa de la microparticula preformada o de nucleo lleva una carga de superficie neta. Una capa esta asociada con la superficie externa de la microparticula preformada o de nucleo. La monocapa incluye al menos un compuesto cargado que tiene una carga que es diferente a la carga de la superficie neta de la microparticula preformada o de nucleo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67537205P | 2005-04-27 | 2005-04-27 | |
US75090305P | 2005-12-16 | 2005-12-16 | |
PCT/US2006/015918 WO2006116546A1 (en) | 2005-04-27 | 2006-04-27 | Surface-modified microparticles and methods of forming and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007013356A true MX2007013356A (es) | 2008-03-26 |
Family
ID=36928379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007013356A MX2007013356A (es) | 2005-04-27 | 2006-04-27 | Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060260777A1 (es) |
EP (1) | EP1885335A1 (es) |
JP (1) | JP2008539259A (es) |
CN (1) | CN101188996B (es) |
AU (1) | AU2006241145B2 (es) |
CA (1) | CA2604225A1 (es) |
MX (1) | MX2007013356A (es) |
WO (1) | WO2006116546A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
WO2006023849A2 (en) | 2004-08-20 | 2006-03-02 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
AU2005277041B2 (en) | 2004-08-23 | 2012-03-22 | Mannkind Corporation | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
KR20120060245A (ko) * | 2005-09-14 | 2012-06-11 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
DE602007008125D1 (de) | 2006-10-31 | 2010-09-09 | Surmodics Pharmaceuticals Inc | Kugelförmige polymer-teilchen |
US8697098B2 (en) | 2011-02-25 | 2014-04-15 | South Dakota State University | Polymer conjugated protein micelles |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN103252007B (zh) | 2008-06-13 | 2016-06-22 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US20100009007A1 (en) * | 2008-07-10 | 2010-01-14 | Baxter International Inc. | Non-covalent modification of microparticles and process of preparing same |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
CN102348462B (zh) | 2008-12-19 | 2015-06-17 | 巴克斯特国际公司 | Tfpi抑制剂和使用方法 |
ES2319158B1 (es) * | 2008-12-23 | 2010-01-26 | Grifols, S.A | Composicion de microparticulas biocompatibles de acido alginico para la liberacion controlada de principios activos por via intravenosa. |
US20110311452A1 (en) * | 2008-12-23 | 2011-12-22 | Board Of Regents Of The University Of Texas System | Inflammation targeting particles |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
AU2010221254B2 (en) | 2009-03-04 | 2014-04-03 | Mannkind Corporation | An improved dry powder drug delivery system |
US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
ES2347119B2 (es) | 2009-04-22 | 2011-04-28 | Universidad De Santiago De Compostela | Nanocapsulas de poliarginina. |
BRPI1013154B1 (pt) | 2009-06-12 | 2020-04-07 | Mannkind Corp | Micropartículas de dicetopiperazina com áreas de superfície específicas definidas, pó seco compreendendo as referidas micropartículas, método para formação das referidasmicropartículas e formação de micropartículas de fumaril diacetopiperazina, uso das referidas micropartículas e sistema de inalação |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
JP5823405B2 (ja) | 2009-11-04 | 2015-11-25 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 核酸含有脂質粒子および関連方法 |
KR101784030B1 (ko) | 2010-03-19 | 2017-10-10 | 백스터 인터내셔널 인코포레이티드 | Tfpi 저해제 및 사용 방법 |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
JP2014515007A (ja) | 2011-02-25 | 2014-06-26 | サウス ダコタ ステート ユニバーシティー | 局所送達のためのタンパク質ナノ担体 |
KR101952599B1 (ko) | 2011-02-25 | 2019-05-22 | 사우스다코타주립대학 | 고분자 컨쥬게이트화된 단백질 마이셀 |
SG10201606220QA (en) | 2011-04-01 | 2016-09-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
KR102263685B1 (ko) | 2012-03-21 | 2021-06-11 | 다케다 야쿠힌 고교 가부시키가이샤 | Tfpi 저해제 및 사용 방법 |
JP2015527310A (ja) | 2012-06-28 | 2015-09-17 | アンサン バイオファーマ, インコーポレイテッドAnsun Biopharma, Inc. | 下気道および中枢気道への送達用微粒子製剤ならびに製造方法 |
US20140154308A1 (en) * | 2012-06-28 | 2014-06-05 | Ansun Biopharma, Inc. | Microparticle Formulations for Delivery to the Upper and Central Respiratory Tract and Methods of Manufacture |
BR112015000529B1 (pt) | 2012-07-12 | 2022-01-11 | Mannkind Corporation | Inalador de pó seco |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
KR102246914B1 (ko) | 2013-03-15 | 2021-04-30 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US11667906B2 (en) * | 2014-11-24 | 2023-06-06 | Corning Incorporated | Magnetic microcarriers |
MX2018005932A (es) | 2015-11-12 | 2019-05-20 | Graybug Vision Inc | Microparticulas aglomerantes para terapia medica. |
EP3600324A4 (en) | 2017-03-23 | 2020-12-09 | Graybug Vision, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS |
BR112019022908A2 (pt) | 2017-05-10 | 2020-05-26 | Graybug Vision, Inc. | Micropartícula de agregação sólida, sólido liofilizado ou reconstituível de micropartículas de agregação, método para tratamento de um distúrbio ocular, e, uso das micropartículas de agregação sólidas |
US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
WO2020114615A1 (en) | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
WO2020115283A1 (en) | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
EP3975841A1 (en) | 2019-05-30 | 2022-04-06 | Massachusetts Institute of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
CN114028606B (zh) * | 2021-10-26 | 2023-06-13 | 湘雅生物医药(湖州)有限公司 | 一种壳聚糖、鱼精蛋白抗菌止血微球及其制备方法 |
CN114984746B (zh) * | 2022-08-05 | 2022-11-01 | 山东建筑大学 | 一种消杀剂及养殖废水池VOCs废气处理系统方法和装置 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
JPS523342B2 (es) * | 1972-01-26 | 1977-01-27 | ||
US4197893A (en) * | 1977-12-15 | 1980-04-15 | Coin Bernard J O | Reuseable puncture shield for tire casings |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) * | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
EP0190833B1 (en) * | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Method for producing microcapsule |
JP2551756B2 (ja) * | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US5102872A (en) * | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
JP2765700B2 (ja) * | 1986-08-11 | 1998-06-18 | イノベータ・バイオメド・リミテツド | マイクロカプセルを含有する医薬調合物 |
US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
USRE39497E1 (en) * | 1989-02-16 | 2007-02-27 | Nektar Therapeutics | Storage of materials |
JPH0739339B2 (ja) * | 1989-05-01 | 1995-05-01 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | 生物活性を有する分子の小粒子の製造方法 |
CA2050911C (en) * | 1989-05-04 | 1997-07-15 | Thomas R. Tice | Encapsulation process and products therefrom |
JPH05502863A (ja) * | 1989-12-05 | 1993-05-20 | トランセル・コーポレイション | 生体内適用および埋め込み用コーティング組成物同種グルロン酸―アルギン酸塩およびその使用方法 |
MY107937A (en) * | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
GB9016885D0 (en) * | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
US5149543A (en) * | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
AU1442592A (en) * | 1991-02-20 | 1992-09-15 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
US6063910A (en) * | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
US5545423A (en) * | 1991-11-25 | 1996-08-13 | Vivorx, Inc. | Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials |
US5525519A (en) * | 1992-01-07 | 1996-06-11 | Middlesex Sciences, Inc. | Method for isolating biomolecules from a biological sample with linear polymers |
US5173454A (en) * | 1992-01-09 | 1992-12-22 | Corning Incorporated | Nanocrystalline materials |
US5912015A (en) * | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
US5286495A (en) * | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
US5417966A (en) * | 1992-06-01 | 1995-05-23 | Gc Corporation | Depilatory composition |
JP2651320B2 (ja) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
JP3277342B2 (ja) * | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
EP0595030A3 (en) * | 1992-10-01 | 1995-06-07 | Tanabe Seiyaku Co | Composition of microspheres with several delayed release nuclei and its preparation process. |
WO1994012158A1 (en) * | 1992-12-02 | 1994-06-09 | Alkermes Controlled Therapeutics, Inc. | Controlled release growth hormone containing microspheres |
US6090925A (en) * | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5554730A (en) * | 1993-03-09 | 1996-09-10 | Middlesex Sciences, Inc. | Method and kit for making a polysaccharide-protein conjugate |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
WO1995013798A1 (en) * | 1993-11-18 | 1995-05-26 | Cancer Research Institute Inc. | Controlled release preparation |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
CA2474701C (en) * | 1993-11-19 | 2009-01-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradeable microparticles containing a biologically active agent |
US5620883A (en) * | 1994-04-01 | 1997-04-15 | The Johns Hopkins University | Living cells microencapsulated in a polymeric membrane having two layers |
US6387399B1 (en) * | 1994-12-02 | 2002-05-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microencapsulated bioactive agents and method of making |
US6265389B1 (en) * | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
JP2909959B2 (ja) * | 1995-10-19 | 1999-06-23 | 三井化学株式会社 | タンパク質超薄膜固定型リアクターの製造方法及び得られたタンパク質超薄膜固定型リアクターを用いた化学反応 |
SE505146C2 (sv) * | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US6270795B1 (en) * | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
CA2192782C (en) * | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
JP2966795B2 (ja) * | 1996-09-30 | 1999-10-25 | 科学技術振興事業団 | 機能性薄膜とその製造方法 |
DE69727244T2 (de) * | 1996-10-03 | 2004-11-25 | Hermes Biosciences Inc., San Francisco | Hydrophile Mikroteilchen und Verfahren zu deren Herstellung |
US6083484A (en) * | 1996-10-17 | 2000-07-04 | Molecular Biosystems, Inc. | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents |
US6395302B1 (en) * | 1996-11-19 | 2002-05-28 | Octoplus B.V. | Method for the preparation of microspheres which contain colloidal systems |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
SE512663C2 (sv) * | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
US6395253B2 (en) * | 1998-04-23 | 2002-05-28 | The Regents Of The University Of Michigan | Microspheres containing condensed polyanionic bioactive agents and methods for their production |
WO2000003797A1 (de) * | 1998-07-15 | 2000-01-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Polyelektrolythüllen auf biologischen templaten |
US6270802B1 (en) * | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
DE19852928C1 (de) * | 1998-11-17 | 2000-08-03 | Steffen Panzner | Strukturen in Form von Hohlkugeln |
US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
US6833192B1 (en) * | 1999-06-10 | 2004-12-21 | Max-Planck Gesellschaft Zur Forderrung Der Wissenschaften E.V. | Encapsulation of crystals via multilayer coatings |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
DE10001172A1 (de) * | 2000-01-13 | 2001-07-26 | Max Planck Gesellschaft | Templatieren von Feststoffpartikeln mit Polymermultischichten |
DE10010264A1 (de) * | 2000-03-02 | 2001-09-13 | Novosom Gmbh | Stabilisierte Liposomen und Hüllstrukturen |
WO2001078687A1 (en) * | 2000-04-18 | 2001-10-25 | Peptron Inc. | Injectable sustained release pharmaceutical composition and processes for preparing the same |
EP1292385A1 (de) * | 2000-04-28 | 2003-03-19 | Rainer Pommersheim | Verfahren und anlage zur herstellung von mikromembrankapseln |
FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
US6998393B2 (en) * | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
KR100392501B1 (ko) * | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
DE10031132A1 (de) * | 2000-06-30 | 2002-01-17 | Henkel Kgaa | Verfahren zur Herstellung aktivstoffhaltiger Kapseln mit ultradünner Wandschicht |
WO2002009865A1 (de) * | 2000-08-02 | 2002-02-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Polyelektrolytkapselherstellung durch oberflächenpräzipitation |
DE60110809T2 (de) * | 2000-08-28 | 2005-10-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Mehrschichtige Polyelektrolytkapseln mit kontrollierter und verzögerter Freisetzung |
US6756062B2 (en) * | 2000-11-03 | 2004-06-29 | Board Of Regents University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
US6862890B2 (en) * | 2001-01-30 | 2005-03-08 | Board Of Regents, University Of Texas System | Process for production of nanoparticles and microparticles by spray freezing into liquid |
US6896905B2 (en) * | 2001-02-15 | 2005-05-24 | Rohm And Haas Company | Porous particles, their aqueous dispersions, and method of preparation |
FR2824754B1 (fr) * | 2001-05-15 | 2004-05-28 | Separex Sa | Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble |
US6878693B2 (en) * | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
CA2463495C (en) * | 2001-10-12 | 2011-05-24 | Elan Pharma International Ltd. | Compositions having a combination of immediate release and controlled release characteristics |
US7112361B2 (en) * | 2001-10-25 | 2006-09-26 | Massachusetts Institute Of Technology | Methods of making decomposable thin films of polyelectrolytes and uses thereof |
US20040014698A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent |
US6896926B2 (en) * | 2002-09-11 | 2005-05-24 | Novartis Ag | Method for applying an LbL coating onto a medical device |
DE10244503A1 (de) * | 2002-09-25 | 2004-04-08 | Capsulution Nanoscience Ag | Methode zur Herstellung und Stabilisierung von Mikro- und Nanosuspensionen mit Amphiphilen und Polyelektrolyten |
EP1646445A4 (en) * | 2003-07-18 | 2007-09-19 | Baxter Int | METHOD OF MANUFACTURING, USING AND COMPOSING SMALL BALLULAR PARTICLES PRODUCED BY CONTROLLED PHASE SEPARATION |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
WO2005009375A2 (en) * | 2003-07-22 | 2005-02-03 | Baxter International Inc. | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
WO2005112893A1 (en) * | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Microspheres comprising protein and showing injectability at high concentrations of said agent |
WO2005112885A2 (en) * | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1 |
DK1765294T3 (da) * | 2004-05-12 | 2008-11-10 | Baxter Int | Nukleinsyremikrokugler samt deres fremstilling og afgivelse |
-
2006
- 2006-04-27 JP JP2008509099A patent/JP2008539259A/ja active Pending
- 2006-04-27 US US11/380,556 patent/US20060260777A1/en not_active Abandoned
- 2006-04-27 WO PCT/US2006/015918 patent/WO2006116546A1/en active Application Filing
- 2006-04-27 EP EP06751564A patent/EP1885335A1/en not_active Withdrawn
- 2006-04-27 MX MX2007013356A patent/MX2007013356A/es active IP Right Grant
- 2006-04-27 CN CN2006800148125A patent/CN101188996B/zh not_active Expired - Fee Related
- 2006-04-27 AU AU2006241145A patent/AU2006241145B2/en not_active Ceased
- 2006-04-27 CA CA002604225A patent/CA2604225A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008539259A (ja) | 2008-11-13 |
CN101188996A (zh) | 2008-05-28 |
AU2006241145A1 (en) | 2006-11-02 |
WO2006116546A1 (en) | 2006-11-02 |
AU2006241145B2 (en) | 2011-04-28 |
CA2604225A1 (en) | 2006-11-02 |
CN101188996B (zh) | 2013-03-27 |
US20060260777A1 (en) | 2006-11-23 |
EP1885335A1 (en) | 2008-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007013356A (es) | Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas. | |
USD728435S1 (en) | Portions of a grille surround | |
DE60334096D1 (de) | Nkoxid, polymerzusammensetzung enthaltend dieses pulver sowie daraus hergestellte formkörper | |
MX2009003661A (es) | Microcapsulas que contienen microparticulas modificadas en la superficie y metodos para formar y utilizar las mismas. | |
AU2003227540A1 (en) | Method for the production and the use of microparticles and nanoparticles by constructive micronisation | |
EP1797319A4 (en) | DRAWER WITH LOADED PARTICLES | |
ES2191616T3 (es) | Polvos pulverizables de fluoropolimeros no fibrilables. | |
PT1257604E (pt) | Sulfato de bário, processo para a sua preparação e sua utilização | |
EP1914264A4 (en) | SURFACE TREATED POWDER AND THIS INCLUDING COSMETICS | |
EP1948852A4 (en) | REFERENCE ELECTRODE AND METHOD FOR PRODUCING THE REFERENCE ELECTRODE | |
AU2003276900A8 (en) | Charged particle beam system | |
EP1773936A4 (en) | NON-AGGLOMERED CORE / COVER NANOVER PARTY | |
EP1964903A4 (en) | THERMO-EXPANDABLE MICROSPHERES, PROCESS FOR THEIR PRODUCTION AND USES THEREOF | |
EP2072462A4 (en) | METHOD FOR MANUFACTURING FINE PARTICLE DISPERSION OF METAL COMPOUND AND DISPERSION THEREOF | |
EP1753902A4 (en) | SYSTEMS AND METHODS FOR PRODUCING NANOTUBULAR STRUCTURES | |
HK1092101A1 (en) | Fine-grain silver powder and process for producing the same | |
EP1969164A4 (en) | NON-SPHERIC SEMICONDUCTOR NANOCRYSTALS AND METHODS FOR REALIZING THE SAME | |
EP1661646A4 (en) | AGGREGATE OF MAGNETIC ALLOY PARTICLES | |
TW200505799A (en) | A process for preparing spherical zinc oxide particles | |
EP1594011A3 (en) | Negatively charged coated electrographic toner particles | |
WO2006060171A3 (en) | Methods and compositions related to phage-nanoparticle assemblies | |
AU2003263024A1 (en) | Process of forming and modifying particles and compositions produced thereby | |
GB0216780D0 (en) | Methods of particle formation | |
WO2006137856A3 (en) | Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility | |
EP1534512A4 (en) | COATED PARTICLES, MANUFACTURING AND USE METHOD |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |