ATE556788T1 - Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie - Google Patents

Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie

Info

Publication number
ATE556788T1
ATE556788T1 AT02725473T AT02725473T ATE556788T1 AT E556788 T1 ATE556788 T1 AT E556788T1 AT 02725473 T AT02725473 T AT 02725473T AT 02725473 T AT02725473 T AT 02725473T AT E556788 T1 ATE556788 T1 AT E556788T1
Authority
AT
Austria
Prior art keywords
acoustic energy
focused acoustic
production
pharmaceutical active
active particles
Prior art date
Application number
AT02725473T
Other languages
English (en)
Inventor
David Lee
Original Assignee
Picoliter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Picoliter Inc filed Critical Picoliter Inc
Application granted granted Critical
Publication of ATE556788T1 publication Critical patent/ATE556788T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT02725473T 2001-03-30 2002-04-01 Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie ATE556788T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/823,899 US6596206B2 (en) 2001-03-30 2001-03-30 Generation of pharmaceutical agent particles using focused acoustic energy
PCT/US2002/010266 WO2002078863A1 (en) 2001-03-30 2002-04-01 Generation of pharmaceutical agent particles using focused acoustic energy

Publications (1)

Publication Number Publication Date
ATE556788T1 true ATE556788T1 (de) 2012-05-15

Family

ID=25240048

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02725473T ATE556788T1 (de) 2001-03-30 2002-04-01 Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie

Country Status (5)

Country Link
US (1) US6596206B2 (de)
EP (1) EP1379337B1 (de)
JP (1) JP2004532102A (de)
AT (1) ATE556788T1 (de)
WO (1) WO2002078863A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6642061B2 (en) * 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US20050260273A1 (en) * 2001-06-07 2005-11-24 Chinea Vanessa I Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology
US7354141B2 (en) * 2001-12-04 2008-04-08 Labcyte Inc. Acoustic assessment of characteristics of a fluid relevant to acoustic ejection
EP1515732B1 (de) 2002-06-12 2009-01-14 Air Liquide Deutschland GmbH Cerebrale protektion mit einem xenonhaltigen gas
EP1515731A1 (de) * 2002-06-12 2005-03-23 Air Liquide Deutschland GmbH Xenonhaltiges spasmolytikum
US7070260B2 (en) * 2003-01-09 2006-07-04 Labcyte Inc. Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge
US7537803B2 (en) * 2003-04-08 2009-05-26 New Jersey Institute Of Technology Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process
WO2005051511A1 (ja) * 2003-11-28 2005-06-09 Mitsubishi Chemical Corporation 有機化合物微粒子の製造方法
KR100603974B1 (ko) * 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
JP2007516259A (ja) * 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
US20060210443A1 (en) 2005-03-14 2006-09-21 Stearns Richard G Avoidance of bouncing and splashing in droplet-based fluid transport
US20070120281A1 (en) * 2005-11-08 2007-05-31 Boris Khusid Manufacture of fine particles and nano particles and coating thereof
WO2007129829A1 (en) * 2006-05-04 2007-11-15 Bio-Synectics Inc. Method for preparing nano-scale particle of active material
WO2008030473A2 (en) * 2006-09-05 2008-03-13 University Of Wyoming Process for forming nanoparticles by micellization of blocky copolymers in subcritical and supercritical solvents
BRPI0720550A2 (pt) * 2006-10-06 2014-07-08 Newsouth Innovations Pty Ltd Formação de partículas
JP5307382B2 (ja) * 2007-11-14 2013-10-02 日機装株式会社 微粒子化方法
CN102858682B (zh) 2010-03-22 2014-07-16 株式会社Bio-Synectics 纳米颗粒制备方法
CN102058996A (zh) * 2010-10-29 2011-05-18 华侨大学 非溶剂法改进超临界抗溶剂过程制备药物超细微粒的方法
US10105316B2 (en) 2012-07-05 2018-10-23 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising muscarinic receptor antagonist
US10111957B2 (en) * 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
US20150290135A1 (en) * 2012-11-16 2015-10-15 Merck Sharp & Dohme Corp. Process for making agglomerates using acoustic mixing technology
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
WO2019040346A1 (en) * 2017-08-25 2019-02-28 Merck Sharp & Dohme Corp. METHODS FOR PREPARING STORED AMORPHOUS MEDICATION FORMULATIONS USING ACOUSTIC FUSION
JP2020023472A (ja) * 2018-07-30 2020-02-13 株式会社リコー 粒子の製造方法、並びに、それにより製造された粒子及び医薬

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308547A (en) 1978-04-13 1981-12-29 Recognition Equipment Incorporated Liquid drop emitter
US5041849A (en) 1989-12-26 1991-08-20 Xerox Corporation Multi-discrete-phase Fresnel acoustic lenses and their application to acoustic ink printing
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
ATE470704T1 (de) * 1995-11-01 2010-06-15 Dnavec Research Inc Rekombinantes sendai-virus
US5874029A (en) 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
JP3986086B2 (ja) * 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
EP1173265B1 (de) 1999-01-29 2005-12-21 Bristol-Myers Squibb Company Vorrichtung und verfahren zur mit ultraschall beaufschlagten strahlkristallisation
US6620351B2 (en) 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB0016002D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US8122880B2 (en) 2000-12-18 2012-02-28 Palo Alto Research Center Incorporated Inhaler that uses focused acoustic waves to deliver a pharmaceutical product
US7121275B2 (en) 2000-12-18 2006-10-17 Xerox Corporation Method of using focused acoustic waves to deliver a pharmaceutical product
US6622720B2 (en) 2000-12-18 2003-09-23 Xerox Corporation Using capillary wave driven droplets to deliver a pharmaceutical product
CA2462259A1 (en) * 2001-09-28 2003-04-10 Dnavec Research Inc. Mammalian cell-infecting virus vector encoding epitope-bound .beta.2m and utilization thereof

Also Published As

Publication number Publication date
WO2002078863A1 (en) 2002-10-10
JP2004532102A (ja) 2004-10-21
US6596206B2 (en) 2003-07-22
EP1379337A1 (de) 2004-01-14
US20020142049A1 (en) 2002-10-03
EP1379337B1 (de) 2012-05-09

Similar Documents

Publication Publication Date Title
ATE556788T1 (de) Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie
AU2002311798A1 (en) Granulation method and device using focused acoustic energy
DK1214058T3 (da) Fremgangsmåde til opnåelse af mikorpartikler
DE60142043D1 (de) Ausgabevorrichtungen und flüssigformulierungen
ATE547162T1 (de) Begasungsverfahren
CO5540369A2 (es) Perfil farmococinetico mejorado de sustancias hidrofobas
ATE408755T1 (de) Osmoseverfahren zur energieerzeugung
JP5115929B2 (ja) 液状物質の処理装置
DE60127290D1 (de) Erzeugung eines therapeutischen mikroschaums
BRPI0513264A (pt) dispositivo de pulverização
AU2002212412A1 (en) Method for making very fine particles consisting of a principle inserted in a host molecule
WO2004112882A3 (en) Method of and system for selective cell destruction
CA2584638A1 (en) Medical device for generating transient bubbles
CY1107332T1 (el) Δοχειο για τον ψεκασμο μιας ουσιας
DK1330199T3 (da) Indretning til arfri fjernelse af tatoveringer
EP2759308A3 (de) Vorrichtung und Verfahren zum Dekontaminieren mittels Ultraschallzerstäubung eines Disinfektionsmittels
TR200200822T2 (tr) Uçucu bileşiklerin sıvı solüsyon içindeki katı maddelerden çıkarılması süreci
BR0306737A (pt) Uso de um agente deionizante lìquido, processo para deionização de um meio de resfriamento de uma célula de combustìvel, e, aparelho de célula de combustìvel
NZ526942A (en) A process for preparing particles of a substance using an anti-solvent technique
DK1492586T3 (da) Nålelös spröjte til subkutan injektion af dråber af flydende stoffer
Battula et al. A miniature shock wave driven micro‐jet injector for needle‐free vaccine/drug delivery
WO2009071788A3 (fr) Procede et dispositif de gravure selective
BR0213220A (pt) Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso
ATE389429T1 (de) Nadellose injektionsvorrichtung
DE50110812D1 (de) Verfahren zur hochdruck-gastrennung