BR0213220A - Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso - Google Patents

Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso

Info

Publication number
BR0213220A
BR0213220A BR0213220-6A BR0213220A BR0213220A BR 0213220 A BR0213220 A BR 0213220A BR 0213220 A BR0213220 A BR 0213220A BR 0213220 A BR0213220 A BR 0213220A
Authority
BR
Brazil
Prior art keywords
interaction
active substance
aqueous medium
poorly soluble
soluble active
Prior art date
Application number
BR0213220-6A
Other languages
English (en)
Inventor
Bernard Freiss
Florence Marciacp
Jacques Fages
Martial Sauceau
Hubert Lochard
Jean-Jacques Letourneau
Christophe Joussot-Dubien
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR0213220A publication Critical patent/BR0213220A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

"PROCESSO DE PREPARAçãO DE COMPOSTOS DE INTERAçãO DE UMA SUBSTâNCIA ATIVA POUCO SOLúVEL EM UM MEIO AQUOSO COM UM SUPORTE POROSO, E, COMPOSTO DE INTERAçãO DE INTERAçãO DE UMA SUBSTâNCIA ATIVA POUCO SOLúVEL EM UM MEIO AQUOSO EM UM SUPORTE AQUOSO". A presente invenção tem por objeto um processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, caracterizado em que ele compreende as etapas seguintes: (a) misturar a substância ativa gerada por fluido supercrítico e a quantidade determinada de suporte poroso; (b) realizar uma etapa de difusão molecular por colocação em contato, em modo estático, de um fluido supercrítico com a mistura obtida na etapa (a) durante o tempo necessário para melhorar a dissolução em um meio aquoso da mistura obtida na etapa (a); (c) lavar o composto de interação obtido na etapa (b) por um fluxo de fluido supercrítico; (d) recuperar as partículas do composto de interação assim formado. Ela refere-se igualmente a um composto susceptível de ser obtido por este processo.
BR0213220-6A 2001-10-12 2002-10-11 Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso BR0213220A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0113178A FR2830760B1 (fr) 2001-10-12 2001-10-12 Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
PCT/FR2002/003474 WO2003043604A1 (fr) 2001-10-12 2002-10-11 Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique

Publications (1)

Publication Number Publication Date
BR0213220A true BR0213220A (pt) 2004-08-31

Family

ID=8868228

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0213220A BRPI0213220B1 (pt) 2001-10-12 2002-10-11 processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso
BR0213220-6A BR0213220A (pt) 2001-10-12 2002-10-11 Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0213220A BRPI0213220B1 (pt) 2001-10-12 2002-10-11 processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso

Country Status (18)

Country Link
US (1) US7390411B2 (pt)
EP (1) EP1434567B1 (pt)
JP (1) JP4401778B2 (pt)
CN (1) CN100396277C (pt)
AT (1) ATE381318T1 (pt)
AU (1) AU2002361279B2 (pt)
BR (2) BRPI0213220B1 (pt)
CA (1) CA2462537C (pt)
CY (1) CY1107306T1 (pt)
DE (1) DE60224215T2 (pt)
DK (1) DK1434567T3 (pt)
ES (1) ES2295446T3 (pt)
FR (1) FR2830760B1 (pt)
HK (1) HK1087019A1 (pt)
MX (1) MXPA04003300A (pt)
PT (1) PT1434567E (pt)
WO (1) WO2003043604A1 (pt)
ZA (1) ZA200402580B (pt)

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FR2854079B1 (fr) * 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
FR2868315B1 (fr) * 2004-04-01 2006-07-14 Pierre Fabre Medicament Sa Procede de preparation d'un compose d'inclusion soluble de substances actives dans une molecule hote avec l'aide d'un agent d'interaction par fluide supercritique
PL2260871T3 (pl) 2004-04-01 2013-10-31 Pf Medicament Kompleksy inkluzyjne zawierające piroksykam, cyklodekstrynę i argininę
FR2876910B1 (fr) * 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
FR2876914A1 (fr) * 2004-10-21 2006-04-28 Pierre Fabre Medicament Sa Complexe comprenant un antibiotique, une cyclodextrine et un agent d'interaction
ITSA20050008A1 (it) * 2005-03-10 2006-09-11 Univ Degli Studi Salerno Processo per la produzione di membrane caricate con uno o piu' principi attivi
ATE466065T1 (de) * 2006-02-10 2010-05-15 Carotech Sdn Bhd Verfahren zur gewinnung hochangereicherter naturstoff-fraktionen aus palmöl unter verwendung von superkritischen und beinahe superkritischen flüssigmedien
FR2944207B1 (fr) * 2009-04-09 2011-05-06 Galderma Res & Dev Compositions comprenant au moins un complexe compose d'un derive d'acide naphtoique et d'au moins une cyclodestrine et leurs utilisations
FR2944280B1 (fr) 2009-04-09 2012-08-03 Galderma Res & Dev Procede de preparation de complexes moleculaires entre adapalene et des cyclodextrines
ES2683950T3 (es) * 2011-04-22 2018-09-28 Pepsico, Inc. Encapsulación de extracto en partículas porosas
EP2884523B1 (en) * 2013-12-16 2020-02-05 IMEC vzw Method for activating a porous layer surface
CN105343893B (zh) * 2015-12-11 2018-07-20 中国药科大学 对乙酰氨基酚-2-羟丙基-β-环糊精包合物制备方法
WO2017118266A1 (en) * 2016-01-08 2017-07-13 Chen Shing-Jye Acellular corneas, methods of producing the same and uses thereof

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Also Published As

Publication number Publication date
DK1434567T3 (da) 2008-05-05
CA2462537A1 (fr) 2003-05-30
CN100396277C (zh) 2008-06-25
CA2462537C (fr) 2011-06-21
FR2830760B1 (fr) 2004-06-04
EP1434567A1 (fr) 2004-07-07
ATE381318T1 (de) 2008-01-15
FR2830760A1 (fr) 2003-04-18
US20050274671A1 (en) 2005-12-15
AU2002361279A1 (en) 2003-06-10
CY1107306T1 (el) 2012-11-21
ES2295446T3 (es) 2008-04-16
WO2003043604A1 (fr) 2003-05-30
DE60224215D1 (de) 2008-01-31
JP2005512621A (ja) 2005-05-12
US7390411B2 (en) 2008-06-24
JP4401778B2 (ja) 2010-01-20
PT1434567E (pt) 2008-02-08
MXPA04003300A (es) 2004-07-23
ZA200402580B (en) 2004-11-04
BRPI0213220B1 (pt) 2018-09-18
CN1713894A (zh) 2005-12-28
AU2002361279B2 (en) 2007-02-08
DE60224215T2 (de) 2008-12-04
HK1087019A1 (en) 2006-10-06
EP1434567B1 (fr) 2007-12-19

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERACAO PARA:INT.CI.A61K 9/16, A61K 47/48, A61P, 29/00, A61P 37/00, A61P 1/00, A61P 3/00

Ipc: A61K 9/16 (2011.01), A61K 47/48 (2011.01), A61P 29

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 9/16 (2006.01), A61P 29/00 (2006.01), A61P 37

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

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