ATE381318T1 - Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum - Google Patents

Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum

Info

Publication number
ATE381318T1
ATE381318T1 AT02796803T AT02796803T ATE381318T1 AT E381318 T1 ATE381318 T1 AT E381318T1 AT 02796803 T AT02796803 T AT 02796803T AT 02796803 T AT02796803 T AT 02796803T AT E381318 T1 ATE381318 T1 AT E381318T1
Authority
AT
Austria
Prior art keywords
porous support
supercritical
fluidum
production
supercritical fluid
Prior art date
Application number
AT02796803T
Other languages
English (en)
Inventor
Bernard Freiss
Florence Marciacq
Jacques Fages
Martial Sauceau
Hubert Lochard
Jean-Jacques Letourneau
Christophe Joussot-Dubien
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of ATE381318T1 publication Critical patent/ATE381318T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
AT02796803T 2001-10-12 2002-10-11 Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum ATE381318T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0113178A FR2830760B1 (fr) 2001-10-12 2001-10-12 Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique

Publications (1)

Publication Number Publication Date
ATE381318T1 true ATE381318T1 (de) 2008-01-15

Family

ID=8868228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02796803T ATE381318T1 (de) 2001-10-12 2002-10-11 Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum

Country Status (18)

Country Link
US (1) US7390411B2 (de)
EP (1) EP1434567B1 (de)
JP (1) JP4401778B2 (de)
CN (1) CN100396277C (de)
AT (1) ATE381318T1 (de)
AU (1) AU2002361279B2 (de)
BR (2) BRPI0213220B1 (de)
CA (1) CA2462537C (de)
CY (1) CY1107306T1 (de)
DE (1) DE60224215T2 (de)
DK (1) DK1434567T3 (de)
ES (1) ES2295446T3 (de)
FR (1) FR2830760B1 (de)
HK (1) HK1087019A1 (de)
MX (1) MXPA04003300A (de)
PT (1) PT1434567E (de)
WO (1) WO2003043604A1 (de)
ZA (1) ZA200402580B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854079B1 (fr) 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
FR2868315B1 (fr) * 2004-04-01 2006-07-14 Pierre Fabre Medicament Sa Procede de preparation d'un compose d'inclusion soluble de substances actives dans une molecule hote avec l'aide d'un agent d'interaction par fluide supercritique
ATE504316T1 (de) * 2004-04-01 2011-04-15 Pf Medicament Einschlusskomplexe enthaltend piroxicam, ein cyklodextrin und arginin
FR2876914A1 (fr) * 2004-10-21 2006-04-28 Pierre Fabre Medicament Sa Complexe comprenant un antibiotique, une cyclodextrine et un agent d'interaction
FR2876910B1 (fr) * 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
ITSA20050008A1 (it) * 2005-03-10 2006-09-11 Univ Degli Studi Salerno Processo per la produzione di membrane caricate con uno o piu' principi attivi
ATE466065T1 (de) * 2006-02-10 2010-05-15 Carotech Sdn Bhd Verfahren zur gewinnung hochangereicherter naturstoff-fraktionen aus palmöl unter verwendung von superkritischen und beinahe superkritischen flüssigmedien
FR2944280B1 (fr) 2009-04-09 2012-08-03 Galderma Res & Dev Procede de preparation de complexes moleculaires entre adapalene et des cyclodextrines
FR2944207B1 (fr) * 2009-04-09 2011-05-06 Galderma Res & Dev Compositions comprenant au moins un complexe compose d'un derive d'acide naphtoique et d'au moins une cyclodestrine et leurs utilisations
BR112013027129A2 (pt) * 2011-04-22 2017-01-10 Pepsico Inc encapsulamento de extrato em partículas porosas
EP2884523B1 (de) * 2013-12-16 2020-02-05 IMEC vzw Verfahren zum Aktivieren einer porösen Schichtoberfläche
CN105343893B (zh) * 2015-12-11 2018-07-20 中国药科大学 对乙酰氨基酚-2-羟丙基-β-环糊精包合物制备方法
US10660988B2 (en) * 2016-01-08 2020-05-26 Acro Biomedical Company. Ltd. Acellular corneas, methods of producing the same and uses thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US189454A (en) * 1877-04-10 Improvement in paper boxes
GB2191715B (en) 1986-06-17 1990-07-25 Midrex Int Bv Method and apparatus for dedusting and desulfurizing gases
JPH0677511B2 (ja) * 1986-12-05 1994-10-05 金印わさび株式会社 香辛成分の包接化合物の製造方法
US4822497A (en) * 1987-09-22 1989-04-18 Modar, Inc. Method for solids separation in a wet oxidation type process
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
FR2629735B1 (fr) * 1988-04-11 1991-03-22 Agronomique Inst Nat Rech Procede d'extraction au dioxyde de carbone supercritique de composes volatils, et composes obtenus
GB9100643D0 (en) 1991-01-11 1991-02-27 Shaffery Michael J Filter system
US5389263A (en) * 1992-05-20 1995-02-14 Phasex Corporation Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX
DE59406065D1 (de) * 1993-03-24 1998-07-02 Ciba Geigy Ag Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
EP0706821A1 (de) 1994-10-06 1996-04-17 Centre De Microencapsulation Verfahren zum Beschichten von Partikeln
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
FR2741619B1 (fr) * 1995-11-28 1998-02-13 Pf Medicament Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
AU709384B2 (en) 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
DE19711393C1 (de) 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
IT1296464B1 (it) 1997-11-19 1999-06-25 Vectorpharma Int Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9824298D0 (en) 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
CN1280875A (zh) * 1999-06-30 2001-01-24 刘士群 用超临界反萃剂制造微粒的方法和装置
FR2798863B1 (fr) * 1999-09-27 2001-12-28 Separex Sa Procede et installation de mise a l'etat adsorbe sur un support poreux de composes actifs contenus dans un produit
FR2799984B1 (fr) 1999-10-21 2002-05-03 Lavipharm Procede de fractionnement d'une matiere composee de plusieurs constituants a l'aide d'un solvant a pression supercritique
FR2803538B1 (fr) 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
FR2815540B1 (fr) * 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
US6896905B2 (en) * 2001-02-15 2005-05-24 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
WO2002089851A1 (fr) 2001-03-06 2002-11-14 Separex (Societe Anonyme) Procede de fabrication de complexes hote-client

Also Published As

Publication number Publication date
ES2295446T3 (es) 2008-04-16
BR0213220A (pt) 2004-08-31
FR2830760A1 (fr) 2003-04-18
ZA200402580B (en) 2004-11-04
FR2830760B1 (fr) 2004-06-04
CA2462537A1 (fr) 2003-05-30
US20050274671A1 (en) 2005-12-15
MXPA04003300A (es) 2004-07-23
EP1434567A1 (de) 2004-07-07
CN1713894A (zh) 2005-12-28
JP2005512621A (ja) 2005-05-12
JP4401778B2 (ja) 2010-01-20
HK1087019A1 (en) 2006-10-06
DE60224215T2 (de) 2008-12-04
WO2003043604A1 (fr) 2003-05-30
AU2002361279B2 (en) 2007-02-08
CA2462537C (fr) 2011-06-21
PT1434567E (pt) 2008-02-08
DE60224215D1 (de) 2008-01-31
CY1107306T1 (el) 2012-11-21
BRPI0213220B1 (pt) 2018-09-18
DK1434567T3 (da) 2008-05-05
US7390411B2 (en) 2008-06-24
CN100396277C (zh) 2008-06-25
EP1434567B1 (de) 2007-12-19
AU2002361279A1 (en) 2003-06-10

Similar Documents

Publication Publication Date Title
HK1087019A1 (en) Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid
US6883559B2 (en) Method and apparatus for gradient generation
CN105363503B (zh) 多组分微液滴微流控芯片及其加工方法
DE602004009681D1 (de) Verfahren zur erzeugung einer emulsion durch verwendung einer mikrokanalverfahrentechnologie
AR011716A1 (es) Una particula efervescente, anhidra, substancialmente , de 75 micrones-2 cm. composicion detergente que la comprende. proceso de fabricacion. metodode lavado
DK324588D0 (da) Maskinel vaskemetode
WO2004018066A3 (en) Aqueous two-phase systems for particle manipulation and encapsulation within microscopic volumes
DE60143261D1 (de) Hämatologie-blutkontrolle und verfahren zu ihrer herstellung
ATE490369T1 (de) Verfahren zur hydrophobierung von textilen materialien
CN102153774A (zh) 一种聚甲基丙烯酸甲酯微流控芯片的表面修饰方法及微流控涂层芯片和应用
Soboleva et al. Aroma molecules as dynamic volatile surfactants: functionality beyond the scent
CN102179193A (zh) 一种异位泡沫的发生方法及其装置
WO2003030867A3 (fr) Procede de preparation d'un compose d'interaction d'un derive anilide avec un support poreux par fluide supercritique
CN104043438A (zh) Fe3O4@Au-BSA磁性纳米复合物的制备及其手性分离应用
ATE368451T1 (de) Verfahren zum überziehen von feststoffteilchen
CN103374343A (zh) 调剖驱油用吸水膨胀材料及其生产方法
NO20064143L (no) Fremgangsmate for bearbeiding av flytende substanser
CN108836353A (zh) 一种油/油汗混合型指纹显现方法
DE60137199D1 (de) Testkarte und verfahren ihrer verwendung
CN103739510A (zh) 含氨基末端及双胺基的表面活性剂的制备方法及分离方法
NL2030592B1 (en) Double-embedded bioenzyme sustained-release gel breaker and preparation method thereof
ATE300594T1 (de) Mulchmethode
RU2109707C1 (ru) Способ приготовления газообразователя для поризации бетонных смесей
RU93037047A (ru) Способ получения концентрата буровых технологических жидкостей
KR970013080A (ko) 불산(hf)용액을 사용한 습식세정시 파티를 감소방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1434567

Country of ref document: EP