ATE240718T1 - Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis - Google Patents

Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis

Info

Publication number
ATE240718T1
ATE240718T1 AT98947168T AT98947168T ATE240718T1 AT E240718 T1 ATE240718 T1 AT E240718T1 AT 98947168 T AT98947168 T AT 98947168T AT 98947168 T AT98947168 T AT 98947168T AT E240718 T1 ATE240718 T1 AT E240718T1
Authority
AT
Austria
Prior art keywords
polymer
active agent
solvent
active ingredients
polymer base
Prior art date
Application number
AT98947168T
Other languages
English (en)
Inventor
Mark A Tracy
John D Herberger
Paul A Burke
Paul F Herbert
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE240718T1 publication Critical patent/ATE240718T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cephalosporin Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
AT98947168T 1997-09-24 1998-09-21 Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis ATE240718T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/935,452 US5989463A (en) 1997-09-24 1997-09-24 Methods for fabricating polymer-based controlled release devices
PCT/US1998/019603 WO1999015154A1 (en) 1997-09-24 1998-09-21 Methods for fabricating polymer-based controlled release preparations

Publications (1)

Publication Number Publication Date
ATE240718T1 true ATE240718T1 (de) 2003-06-15

Family

ID=25467166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98947168T ATE240718T1 (de) 1997-09-24 1998-09-21 Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis

Country Status (11)

Country Link
US (2) US5989463A (de)
EP (1) EP1017367B1 (de)
JP (1) JP2001517615A (de)
AT (1) ATE240718T1 (de)
AU (1) AU746337B2 (de)
CA (1) CA2304662C (de)
DE (1) DE69814885T2 (de)
DK (1) DK1017367T3 (de)
ES (1) ES2200375T3 (de)
PT (1) PT1017367E (de)
WO (1) WO1999015154A1 (de)

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AU9400998A (en) 1999-04-12
DK1017367T3 (da) 2003-09-22
PT1017367E (pt) 2003-10-31
US5989463A (en) 1999-11-23
AU746337B2 (en) 2002-04-18
JP2001517615A (ja) 2001-10-09
DE69814885D1 (de) 2003-06-26
ES2200375T3 (es) 2004-03-01
WO1999015154A1 (en) 1999-04-01
EP1017367A1 (de) 2000-07-12
DE69814885T2 (de) 2004-05-19
CA2304662C (en) 2007-09-18
CA2304662A1 (en) 1999-04-01
US6455074B1 (en) 2002-09-24
EP1017367B1 (de) 2003-05-21

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