KR930017574A - 중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법 - Google Patents

중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법 Download PDF

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Publication number
KR930017574A
KR930017574A KR1019930002180A KR930002180A KR930017574A KR 930017574 A KR930017574 A KR 930017574A KR 1019930002180 A KR1019930002180 A KR 1019930002180A KR 930002180 A KR930002180 A KR 930002180A KR 930017574 A KR930017574 A KR 930017574A
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South Korea
Prior art keywords
nonsolvent
polymer
biologically active
active substance
droplets
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KR1019930002180A
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English (en)
Inventor
카르디나 안나 마리아 크리스티나 디릭스
헨드리쿠스 요하네스 마리아 캄프
안토니우스 파울루스 삼
Original Assignee
에프.지.엠.헤르만스. 에이.지.제이. 베르미렌
악조 엔. 브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에프.지.엠.헤르만스. 에이.지.제이. 베르미렌, 악조 엔. 브이. filed Critical 에프.지.엠.헤르만스. 에이.지.제이. 베르미렌
Publication of KR930017574A publication Critical patent/KR930017574A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

본 발명은 생물학적 활성 물질을 함유하는 미소캡슐을 제조하는 방법에 관한 것이다. 상기 방법은 활성 물질이 투입되어 있는 용매에 중합체를 용해하고 생성된 현택액 또는 용액을 분무하고 활성 물질을 함유한 중합체 소적에 대한 비용매내에 소적을 수집하여 응고물을 생성하는 것을 포함한다. 이어서 응고된 소적을 2차 비용매내에서 경화시킨다.

Description

중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따라 제조된 미소캡슐로부터의 에스트라디올 방출을 도시한다. 제2도는 본 발명에 따라 제조된 미소캡슐로부터의 헥사펩티드 H-Gly-Phe-Met(O2)-D-Lys-Phe-OH(β-엔도르핀 62-67 유도체)의 방출을 도시한다. 제3도는 본 발명에 따라 제조된 미소캡슐로부터의 헥사펩티드 Org2766 (H-Met(O)2-Glu-His-Phe-D-Lys-Phe-OH) 방출을 도시한다.

Claims (7)

  1. 활성제가 용해되어 있거나 또는 현탁되어 있는 용매에 중합체를 용해하고, 형성된 영액 또는 현탁액을 분무하고, 이어서 비용매내에 상기 형성된 소적(小適)을 수집함으로써 용액 또는 현탁액을 형성시키는 것을 포함하는 중합체 미소캡슐을 함유하는 생물학적 활성제의 제조방법에 있어서, 상기 응고된 소적을 연이어서 2차 비용매에 옮기는 것을 특징으로 하는 방법.
  2. 제1항에 있어서, 상기 분무 방법이 초음파 분무인 것을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, 상기 중합체가 생분해성인 것을 특징으로 하는 방법.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 상기 중합체가 락트산과 글리콜산의 공중합체인 것을 특징으로 하는 방법.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 2차 비용매가 물인 것을 특징으로 하는 방법.
  6. 제1항 내지 제4항 중 어느 한항에 있어서, 상기 중합체를 아세톤에 용해하고, 상기 1차 비용매가 에탄올 또는 에탄올-물 혼합물이고, 상기 2차 비용매가 물인 것을 특징으로 하는 방법.
  7. 제1항 내지 제6항중 어느 한항에 있어서, 상기 분무되는 용액 또는 현탁액이 또한 소량의 비용매를 함유하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930002180A 1992-02-18 1993-02-17 중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법 KR930017574A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92.200.4668 1992-02-18
EP92200466 1992-02-18

Publications (1)

Publication Number Publication Date
KR930017574A true KR930017574A (ko) 1993-09-20

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Application Number Title Priority Date Filing Date
KR1019930002180A KR930017574A (ko) 1992-02-18 1993-02-17 중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법

Country Status (16)

Country Link
US (1) US5389379A (ko)
EP (1) EP0556917B1 (ko)
JP (1) JPH05337360A (ko)
KR (1) KR930017574A (ko)
AT (1) ATE138263T1 (ko)
AU (1) AU658715B2 (ko)
CA (1) CA2089354A1 (ko)
DE (1) DE69302721T2 (ko)
DK (1) DK0556917T3 (ko)
ES (1) ES2090836T3 (ko)
FI (1) FI930672A (ko)
GR (1) GR3020417T3 (ko)
MX (1) MX9300851A (ko)
NO (1) NO930557L (ko)
NZ (1) NZ245914A (ko)
ZA (1) ZA93929B (ko)

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Also Published As

Publication number Publication date
GR3020417T3 (en) 1996-10-31
FI930672A0 (fi) 1993-02-16
AU3313493A (en) 1993-08-19
EP0556917B1 (en) 1996-05-22
MX9300851A (es) 1994-08-31
US5389379A (en) 1995-02-14
ATE138263T1 (de) 1996-06-15
NZ245914A (en) 1995-02-24
AU658715B2 (en) 1995-04-27
CA2089354A1 (en) 1993-08-19
FI930672A (fi) 1993-08-19
DE69302721T2 (de) 1996-09-19
DE69302721D1 (de) 1996-06-27
NO930557D0 (no) 1993-02-17
ES2090836T3 (es) 1996-10-16
EP0556917A1 (en) 1993-08-25
JPH05337360A (ja) 1993-12-21
ZA93929B (en) 1993-09-10
NO930557L (no) 1993-08-19
DK0556917T3 (da) 1996-09-16

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