KR890007789A - 수용성 펩타이드 및 단백질의 생체분해 가능한 마이크로캡슐의 제조방법 및 이 방법에 의해 수득되는 마이크로캡슐 - Google Patents
수용성 펩타이드 및 단백질의 생체분해 가능한 마이크로캡슐의 제조방법 및 이 방법에 의해 수득되는 마이크로캡슐 Download PDFInfo
- Publication number
- KR890007789A KR890007789A KR1019880014687A KR880014687A KR890007789A KR 890007789 A KR890007789 A KR 890007789A KR 1019880014687 A KR1019880014687 A KR 1019880014687A KR 880014687 A KR880014687 A KR 880014687A KR 890007789 A KR890007789 A KR 890007789A
- Authority
- KR
- South Korea
- Prior art keywords
- phb
- plga
- microcapsules
- weight
- solution
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Peptides Or Proteins (AREA)
- Colloid Chemistry (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 펩타이드 또는 단백질을, 단일중합체 폴리하이드록시부티르산(PHB) 및 공중합체 폴리락타이드코(CO)-클리콜라이드(PLGA)의 혼합물(PHB:PLGA 혼합비율은 99:1 내지 20:80중량%이다)의 용액내에 현탁시키거나 용해시키거나, 또는 펩타이드 또는 단백질의 수용액을 PHB 및 PLGA의 혼합물(PHB:PLGA 혼합비율은 99:1 내지 20:80중량%이다)의 용액내에 유화시키고, 계속해서 현탁액, 용액 또는 유액을 분무시키는 단계를 포함함을 특징으로 하여, 수용성 펩타이드 및 단백질의 생체분해가능한 마이크로캡슐을 제조하는 방법.
- 제1항에 있어서, PHB함량이 90 내지 40중량%이고 PLGA함량이 10 내지 60중량%인 혼합물을 사용하는 방법.
- 제1항에 있어서, 사용되는 활성 화합물이 부세렐린, 프로티렐린, 소마토리베린 또는 안지오게닌 또는 이들 화합물중 하나의 생리적으로 허용되는 염인 방법.
- 제1항에 있어서, 부세렐린 또는 생리적으로 허용되는 부세렐린 염을 사용하는 방법.
- 제1항에 있어서, 부가적으로 방출 조절제를 사용하는 방법.
- 제1항에 있어서, 특허청구된 방법에 의해 수득 가능한 마이크로캡슐.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873738228 DE3738228A1 (de) | 1987-11-11 | 1987-11-11 | Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln |
DEP3738228.4 | 1987-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890007789A true KR890007789A (ko) | 1989-07-05 |
Family
ID=6340243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880014687A KR890007789A (ko) | 1987-11-11 | 1988-11-09 | 수용성 펩타이드 및 단백질의 생체분해 가능한 마이크로캡슐의 제조방법 및 이 방법에 의해 수득되는 마이크로캡슐 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0315875A1 (ko) |
JP (1) | JPH01155942A (ko) |
KR (1) | KR890007789A (ko) |
AU (1) | AU2503788A (ko) |
DE (1) | DE3738228A1 (ko) |
DK (1) | DK627488A (ko) |
FI (1) | FI885152A (ko) |
IL (1) | IL88370A0 (ko) |
NO (1) | NO885013L (ko) |
PT (1) | PT88974A (ko) |
ZA (1) | ZA888396B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3916020C2 (de) * | 1989-05-17 | 1994-06-01 | Burkhard Dr Wichert | Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen |
HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
DE59003337D1 (de) * | 1989-10-16 | 1993-12-09 | Danubia Petrochem Polymere | Pressling mit retardierter Wirkstofffreisetzung. |
DE4041563A1 (de) * | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
YU48420B (sh) * | 1991-03-25 | 1998-07-10 | Hoechst Aktiengesellschaft | Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem |
ATE154241T1 (de) * | 1991-10-01 | 1997-06-15 | Takeda Chemical Industries Ltd | Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe |
JP2651320B2 (ja) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
AU4198793A (en) * | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
DE59309257D1 (de) * | 1992-10-26 | 1999-02-11 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung von mikrokapseln |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
DE60130917T2 (de) | 2000-12-21 | 2008-07-17 | Alrise Biosystems Gmbh | Induziertes phasenübergangsverfahren zur herstellung von hydrophile wirkstoffe enthaltenden mikropartikeln |
CA2447619A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | A composition for accelerating bone fracture healing |
MXPA03010672A (es) | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
KR20030024103A (ko) * | 2001-09-17 | 2003-03-26 | 육순홍 | 상전이 현상을 이용한 약물전달용 생분해성 고분자미소구의 제조방법 |
CN105963258B (zh) * | 2016-04-26 | 2021-01-22 | 广州帝奇医药技术有限公司 | 一种缓释微粒的制备方法 |
CN105963257B (zh) * | 2016-04-26 | 2021-01-22 | 广州帝奇医药技术有限公司 | 一种缓释微粒的制备方法 |
CN108525617B (zh) * | 2018-04-26 | 2020-01-14 | 中国农业科学院植物保护研究所 | 降低稻瘟酰胺对斑马鱼毒性的稻瘟酰胺微囊制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
DE3428372A1 (de) * | 1984-08-01 | 1986-02-13 | Hoechst Ag, 6230 Frankfurt | Mikrokapseln von regulatorischen peptiden mit kontrollierter freisetzung, verfahren zu ihrer herstellung und injektionszubereitungen |
ATE61935T1 (de) * | 1985-02-07 | 1991-04-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
-
1987
- 1987-11-11 DE DE19873738228 patent/DE3738228A1/de not_active Withdrawn
-
1988
- 1988-11-02 EP EP88118180A patent/EP0315875A1/de not_active Withdrawn
- 1988-11-09 KR KR1019880014687A patent/KR890007789A/ko not_active Application Discontinuation
- 1988-11-09 FI FI885152A patent/FI885152A/fi not_active Application Discontinuation
- 1988-11-09 ZA ZA888396A patent/ZA888396B/xx unknown
- 1988-11-10 PT PT88974A patent/PT88974A/pt not_active Application Discontinuation
- 1988-11-10 JP JP63282641A patent/JPH01155942A/ja active Pending
- 1988-11-10 DK DK627488A patent/DK627488A/da not_active Application Discontinuation
- 1988-11-10 NO NO88885013A patent/NO885013L/no unknown
- 1988-11-11 AU AU25037/88A patent/AU2503788A/en not_active Abandoned
- 1988-11-14 IL IL88370A patent/IL88370A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO885013L (no) | 1989-05-12 |
DK627488A (da) | 1989-05-12 |
NO885013D0 (no) | 1988-11-10 |
EP0315875A1 (de) | 1989-05-17 |
FI885152A (fi) | 1989-05-12 |
JPH01155942A (ja) | 1989-06-19 |
IL88370A0 (en) | 1989-06-30 |
FI885152A0 (fi) | 1988-11-09 |
AU2503788A (en) | 1989-05-25 |
PT88974A (pt) | 1989-11-30 |
ZA888396B (en) | 1989-07-26 |
DK627488D0 (da) | 1988-11-10 |
DE3738228A1 (de) | 1989-05-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR890007789A (ko) | 수용성 펩타이드 및 단백질의 생체분해 가능한 마이크로캡슐의 제조방법 및 이 방법에 의해 수득되는 마이크로캡슐 | |
NO982364D0 (no) | FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕten | |
KR940003540A (ko) | 수용성 약제의 마이크로캡슐의 제조방법 | |
Alex et al. | Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment | |
CA2036089A1 (en) | Prolonged release microcapsules | |
KR930017574A (ko) | 중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법 | |
KR910015288A (ko) | 서방성 마이크로캡슐 | |
KR940703713A (ko) | 마이크로캡슐의 제조방법(verfahren zur herstellung von mi-krokapseln) | |
KR850007559A (ko) | 조절 펩타이드의 삽입식 제형 | |
DE50108380D1 (de) | Hautbehandlungsmittel | |
KR920003962A (ko) | 서방형 제제 및 그의 제조 방법 | |
ATE130511T1 (de) | Gefriergetrocknete polymerdispersionen und ihre anwendung zur darstellung von arzneimittelzubereitungen mit protrahierter wirkstoffabgabe. | |
DE69418101D1 (de) | Die Herstellung von wasserunlöslichen Proteinverkapselten gasenthaltenden Mikrosphären, | |
ATE184480T1 (de) | Verfahren zur herstellung von arzneizubereitungen mit verzögerter wirkstoffabgabe | |
ATE127686T1 (de) | Herstellungsverfahren von mikrokugeln. | |
ATE23439T1 (de) | Mikrokapseln mit waenden aus einer mischung von vernetzten polyholosiden und proteinen sowie verfahren zu deren herstellung. | |
KR860001592A (ko) | 조정펩티드의 제어방출 미세캡슐 | |
ATE92075T1 (de) | Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form. | |
US3538216A (en) | Injectable compositions of a drug suspended in an emulsion | |
GB1482663A (en) | Processes for the preparation of microbeads and use in the microbeads thus produced in the preparation of injectable medicaments | |
NL6710475A (ko) | ||
CA2105793A1 (en) | Process for producing compositions for ruminants | |
KR880004822A (ko) | 칼슘 아세테이트/글리세롤 부가물-함유 조절 펩타이드의 비경구 데포 제형, 그의 제조방법 및 부가물의 용도 | |
ES2046818T3 (es) | Procedimiento para la eliminacion de colesterol a partir de yema de huevo. | |
KR910014111A (ko) | 수용성 약물에 대한 서방출성 마이크로캡슐(Microcapsule) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |