GB1482663A - Processes for the preparation of microbeads and use in the microbeads thus produced in the preparation of injectable medicaments - Google Patents

Processes for the preparation of microbeads and use in the microbeads thus produced in the preparation of injectable medicaments

Info

Publication number
GB1482663A
GB1482663A GB3338074A GB3338074A GB1482663A GB 1482663 A GB1482663 A GB 1482663A GB 3338074 A GB3338074 A GB 3338074A GB 3338074 A GB3338074 A GB 3338074A GB 1482663 A GB1482663 A GB 1482663A
Authority
GB
United Kingdom
Prior art keywords
microbeads
preparation
suitably
active ingredient
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3338074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1482663A publication Critical patent/GB1482663A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/18—In situ polymerisation with all reactants being present in the same phase
    • B01J13/185—In situ polymerisation with all reactants being present in the same phase in an organic phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

1482663 Encapsulated medicaments ROUSSEL-UCLAF 29 July 1974 [27 July 1973] 33380/74 Heading A5B [Also in Division B8] A process for the preparation of microbeads which comprise at least one water-insoluble or sparingly soluble pharmacuetically-active ingredient enclosed within a mantle composed of at least one methacrylic polymer, the mean diameter of said microbeads being within the range of from 1-90 microns, in which an organic phase, comprising the methacrylic monomer or mixture of such monomers, a cross-linking agent and the pharmaceutically active ingredient is emulsified in an aqueous phase containing one or more salt(s) under agitation with a rotary stirrer running at a speed of at least 1000 r.p.m., a polymerisation catalyst is then added to the emulsion thus formed, the polymerisation is allowed to proceed, and the microbeads thus formed are recovered. The methacrylic polymer is suitably a copolymer of methacrylic acid and/or methyl acrylate and/or butyl acrylate. The active ingredient is suitably one of the following:- hormones and contraceptive agents, corticosteroids, antibiotics, antiparasitic agents and cytostatic or cytolitic agents. The exemplified active ingredients are testosterone acetate, chlorpromazine and 13#-ethyl-17α ethynyl- 17#-hydroxy-gona-4, 9, 11-triene-3-one. In the preparation, the salt(s) present in the aqueous phase are preferably alkali metal, alkaline earth metal or ammonium sulphate, the crosslinking agent may be divinyl benzene, and the catalyst is suitably 2, 2'-azo bis-isobutyronitrile.
GB3338074A 1973-07-27 1974-07-29 Processes for the preparation of microbeads and use in the microbeads thus produced in the preparation of injectable medicaments Expired GB1482663A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7327577A FR2238477B1 (en) 1973-07-27 1973-07-27

Publications (1)

Publication Number Publication Date
GB1482663A true GB1482663A (en) 1977-08-10

Family

ID=9123241

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3338074A Expired GB1482663A (en) 1973-07-27 1974-07-29 Processes for the preparation of microbeads and use in the microbeads thus produced in the preparation of injectable medicaments

Country Status (8)

Country Link
JP (1) JPS5076223A (en)
BE (1) BE818154A (en)
DE (1) DE2435664A1 (en)
DK (1) DK404274A (en)
FR (1) FR2238477B1 (en)
GB (1) GB1482663A (en)
LU (1) LU70619A1 (en)
NL (1) NL7409978A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464434A (en) * 1978-03-13 1984-08-07 Celanese Corporation Microencapsulated alkaloidal material and method of producing same
EP0143608A2 (en) * 1983-11-25 1985-06-05 Ciba Specialty Chemicals Water Treatments Limited Manufacture and use of polymeric beads
EP0162910A1 (en) * 1983-11-25 1985-12-04 Exxon Research Engineering Co Polymer article of manufacture.
AU642010B2 (en) * 1990-05-16 1993-10-07 Basf Aktiengesellschaft Microcapsules
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
US6822000B2 (en) 2001-05-11 2004-11-23 Ap Pharma, Inc. Bioerodible poly (orthoesters) from dioxolane-based diketene acetals

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6187734A (en) * 1984-10-03 1986-05-06 Japan Synthetic Rubber Co Ltd Production of hollow polymer particle
US4690825A (en) * 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464434A (en) * 1978-03-13 1984-08-07 Celanese Corporation Microencapsulated alkaloidal material and method of producing same
EP0143608A2 (en) * 1983-11-25 1985-06-05 Ciba Specialty Chemicals Water Treatments Limited Manufacture and use of polymeric beads
EP0162910A1 (en) * 1983-11-25 1985-12-04 Exxon Research Engineering Co Polymer article of manufacture.
EP0143608A3 (en) * 1983-11-25 1987-03-04 Allied Colloids Limited Manufacture of polymeric beads
EP0162910A4 (en) * 1983-11-25 1987-03-26 Exxon Research Engineering Co Polymer article of manufacture.
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
AU642010B2 (en) * 1990-05-16 1993-10-07 Basf Aktiengesellschaft Microcapsules
US6822000B2 (en) 2001-05-11 2004-11-23 Ap Pharma, Inc. Bioerodible poly (orthoesters) from dioxolane-based diketene acetals

Also Published As

Publication number Publication date
JPS5076223A (en) 1975-06-21
DK404274A (en) 1975-04-01
BE818154A (en) 1975-01-27
NL7409978A (en) 1975-01-29
DE2435664A1 (en) 1975-02-06
FR2238477A1 (en) 1975-02-21
FR2238477B1 (en) 1976-12-03
LU70619A1 (en) 1975-05-21

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