KR940703713A - 마이크로캡슐의 제조방법(verfahren zur herstellung von mi-krokapseln) - Google Patents

마이크로캡슐의 제조방법(verfahren zur herstellung von mi-krokapseln)

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Publication number
KR940703713A
KR940703713A KR1019940702042A KR19940702042A KR940703713A KR 940703713 A KR940703713 A KR 940703713A KR 1019940702042 A KR1019940702042 A KR 1019940702042A KR 19940702042 A KR19940702042 A KR 19940702042A KR 940703713 A KR940703713 A KR 940703713A
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KR
South Korea
Prior art keywords
solvent
biodegradable
water
microcapsules
dissolved
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Application number
KR1019940702042A
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English (en)
Other versions
KR100225983B1 (ko
Inventor
브루노 간데르
한스 페테르 메르클레
Original Assignee
클라우스-디에톨 허멜리히, 디에트히 샤스트
쉬바르츠 파르마 에이지
디에트히 샤스트
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Publication of KR940703713A publication Critical patent/KR940703713A/ko
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Publication of KR100225983B1 publication Critical patent/KR100225983B1/ko

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution

Abstract

생물학적으로 분해 가능한 중합체를 바탕으로 생물학적 분해 가능한 용매를 사용해서 그 이외의 독성 용매 없이도 마이크로캡슐을 생산하는 마이크로캡슘의 제조 과정에 관해 설명하였다. 사용된 용매는 일차 에스테르이고 이 에스테르는 C1-C3-알콜과 C2-C3-모노카르본산과 에스테르의 혼합물로 이루어져 있다. 이러한 용매는 첨가물 C2-C3-알콜을 가지고 있을수 없다. 작용 물질로써 물에 녹거나 녹지 않는 물질이 사용된다. 약제, 펩타이드, 단백질, 효소, 왁찐과 같이 물에 용해되는 작용 물질은 중합체 용액에서 물로된 용액으로써 미세분된다. 마이크로캡슐은 용액의 분무, 현탁액, 작용 물질과 생물학적 분리 가능한 중합체로부터의 W/O-미세분을 통해 얻어진다. 이과정은 약제, 왁찐, 효소 제조에 사용된다.

Description

마이크로캡슐의 제조방법(VERFAHREN ZUR HERSTELLUNG VON MIKROKAPSELN)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 생물학적으로 분해 가능한 중합체를 가지고 만든 마이크로캡슐의 제조 과정은 생물학적 분해 가능한 중합체가 생물학적으로 분해되는 용매로 용해 되어질 수 있다는 것을 통해(1단계), 작용 물질이 중합체용액으로 감입되어진다는 것을 통해(2단계), 그러면서 작용물질이 생물학적 분해되는 용매 속에서 용해 되어지고(3단계) 그것을 통해 얻은 유기적인 작용 물질 용액과 중합체 용액이 혼합되고(4단계) 또는 중합체 용액속에서 현탁되거나(5단계) 물로된 매개체 속에서 용해 되고(6단계) 그것을 통해 물로된 작용 물질 용액이은 중합체 용액에서 미세하게 미세분되고(7단계) 용액, 현탁액, W/O-미세분 그다음에 분무 건조되어지는(8단계)것을 특징으로하는 마이크로캡슐의 제조방법.
  2. 제 1 항에 있어서, 생물학적 분해 가능한 용매로 최소한 일차 에스테르가 사용되어 지는 것을 특징으로 한 마이크로캡슐의 제조방법.
  3. 제 1 항에 있어서, 생물학적 분해 가능한 용매로 최소한 일차 에스테르와 C1-C5알콜이 사용되어 지는것을 특징으로 한 마이크로캡슐의 제조방법.
  4. 제 1 항 내지 제 3 항에 있어서, C1-C3-알콜과 C1-C3모노카르본산으로 구성되어진 일차 에스테르가 사용되어 지는것을 특징으로 한 마이크로캡슐의 제조방법.
  5. 제 1 항에 있어서, 생물학적 분해 가능한 용매로 개미산에틸에스테르가 사용되어 지는것을 특징으로 한 마이크로캡슐의 제조방법.
  6. 제 1 항에 있어서, 생물학적 분해 가능한 용매로 초산에틸에스테르 또는 초산이소프로필에스테르가 사용되어 지는 것을 특징으로 한 마이크로캡슐의 제조방법.
  7. 제 1 항에 있어서, 생물학적 분해 가능한 용매 속에서 용해되지 않는 작용 물질이 물로된 매개체에서 용해되어지고(6단계) 초음파를 통해 생물학적 분해 가능한 용매 속에서 미세하게 미분화 되는 것을 특징으로 한 마이크로캡슐의 제조방법.
  8. 제 1 항 내지 제 7 항에 있어서, 작용 물질로서 약제, 펩타이드, 단백질, 효소, 왁찐이 사용되는 것을 특징으로 한 마이크로캡슐의 제조방법.
  9. 제 1 항 내지 제 8 항에 있어서, 작용 물질이 고체 또는 액체 형태로 사용되는 것을 특징으로 한 마이크로캡슐의 제조방법.
  10. 약제, 왁찐, 효소를 함유한 마이크로캡슐 제조를 위한 청구범위 제 1 항 내지 제 9 항의 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702042A 1992-10-26 1993-10-18 마이크로캡슐의 제조 방법 KR100225983B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH331992 1992-10-26
CH3319/92-3 1992-10-26
PCT/CH1993/000246 WO1994009898A1 (de) 1992-10-26 1993-10-18 Verfahren zur herstellung von mikrokapseln

Publications (2)

Publication Number Publication Date
KR940703713A true KR940703713A (ko) 1994-12-12
KR100225983B1 KR100225983B1 (ko) 1999-10-15

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US (1) US5648096A (ko)
EP (1) EP0625069B1 (ko)
JP (1) JP3523254B2 (ko)
KR (1) KR100225983B1 (ko)
CN (1) CN1058864C (ko)
AT (1) ATE175132T1 (ko)
CA (1) CA2126685C (ko)
DE (1) DE59309257D1 (ko)
DK (1) DK0625069T3 (ko)
ES (1) ES2127835T3 (ko)
FI (1) FI943067A (ko)
GR (1) GR3029504T3 (ko)
HU (1) HU221308B1 (ko)
WO (1) WO1994009898A1 (ko)

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US5648096A (en) 1997-07-15
FI943067A0 (fi) 1994-06-23
DK0625069T3 (da) 1999-08-30
CN1090172A (zh) 1994-08-03
FI943067A (fi) 1994-06-23
CA2126685A1 (en) 1994-05-11
KR100225983B1 (ko) 1999-10-15
WO1994009898A1 (de) 1994-05-11
DE59309257D1 (de) 1999-02-11
HU9401329D0 (en) 1994-08-29
EP0625069B1 (de) 1998-12-30
HUT70418A (en) 1995-10-30
EP0625069A1 (de) 1994-11-23
CN1058864C (zh) 2000-11-29
ES2127835T3 (es) 1999-05-01
JP3523254B2 (ja) 2004-04-26
CA2126685C (en) 2002-07-23
ATE175132T1 (de) 1999-01-15
JPH07502686A (ja) 1995-03-23

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