ES2127835T3 - Procedimiento para la preparacion de microcapsulas. - Google Patents
Procedimiento para la preparacion de microcapsulas.Info
- Publication number
- ES2127835T3 ES2127835T3 ES93922486T ES93922486T ES2127835T3 ES 2127835 T3 ES2127835 T3 ES 2127835T3 ES 93922486 T ES93922486 T ES 93922486T ES 93922486 T ES93922486 T ES 93922486T ES 2127835 T3 ES2127835 T3 ES 2127835T3
- Authority
- ES
- Spain
- Prior art keywords
- microcapsules
- water
- active substances
- solution
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003094 microcapsule Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- 239000002904 solvent Substances 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- 229920002988 biodegradable polymer Polymers 0.000 abstract 2
- 239000004621 biodegradable polymer Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940079919 digestives enzyme preparation Drugs 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
Abstract
SE DESCRIBE UN PROCESO PARA LA ELABORACION DE MICROCAPSULAS A PARTIR DE POLIMEROS BIODEGRADABLES, UTILIZANDO EL METODO DISOLVENTE BIODEGRADABLE Y PRODUCIENDO MICROCAPSULAS QUE ESTAN LIBRES DE RESIDUOS DISOLVENTES TOXICOS. LOS DISOLVENTES UTILIZADOS INCLUYEN ESTERES SIMPLES FABRICADOS A PARTIR DE C1 C5 ALCOHOL Y UN C1 ALES ESTERES, Y CONTENIENDO EL DISOLVENTE TAMBIEN UN C1 LCOHOL. AMBAS SUSTANCIAS ACTIVAS SOLUBLES EN AGUA E INSOLUBLES EN AGUA PUEDEN SER INCORPORADAS EN LAS MICROCAPSULAS. LAS SUSTANCIAS ACTIVAS SOLUBLES EN AGUA TALES COMO MEDICAMENTOS, PEPTIDOS, PROTEINAS, ENZIMAS Y VACUNAS SON DISPERSADAS PREFERENTEMENTE EN SOLUCION ACUOSA EN LA SOLUCION POLIMERA. LAS MICROCAPSULAS SON PRODUCIDAS MEDIANTE EL ROCIADO DE UNA SOLUCION, SUSPENSION EN DISPERSION DE AGUA EN ACEITE DE SUSTANCIAS ACTIVAS Y POLIMEROS BIODEGRADABLES. EL METODO ES ADECUADO PARA SU UTILIZACION EN LA FABRICACION DE MEDICAMENTOS, VACUNAS Y PREPARACIONES DE ENZIMAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH331992 | 1992-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2127835T3 true ES2127835T3 (es) | 1999-05-01 |
Family
ID=4253421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93922486T Expired - Lifetime ES2127835T3 (es) | 1992-10-26 | 1993-10-18 | Procedimiento para la preparacion de microcapsulas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5648096A (es) |
EP (1) | EP0625069B1 (es) |
JP (1) | JP3523254B2 (es) |
KR (1) | KR100225983B1 (es) |
CN (1) | CN1058864C (es) |
AT (1) | ATE175132T1 (es) |
CA (1) | CA2126685C (es) |
DE (1) | DE59309257D1 (es) |
DK (1) | DK0625069T3 (es) |
ES (1) | ES2127835T3 (es) |
FI (1) | FI943067A (es) |
GR (1) | GR3029504T3 (es) |
HU (1) | HU221308B1 (es) |
WO (1) | WO1994009898A1 (es) |
Families Citing this family (95)
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US6410056B1 (en) | 1984-03-16 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
USRE40786E1 (en) | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
US20030161889A1 (en) * | 1984-03-16 | 2003-08-28 | Reid Robert H. | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
US6217911B1 (en) * | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
AU8303691A (en) | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
JP3583128B2 (ja) * | 1993-01-08 | 2004-10-27 | シーエスエル、リミテッド | ワクチン製剤 |
US6939546B2 (en) | 1993-05-21 | 2005-09-06 | The United States Of America As Represented By The Secretary Of The Army | Model for testing immunogenicity of peptides |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
US6855331B2 (en) | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
GB9420355D0 (en) | 1994-10-10 | 1994-11-23 | Univ Nottingham | Preparation of protein microspheres, films and coatings |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
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US7033608B1 (en) | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
WO1997013503A1 (en) * | 1995-10-13 | 1997-04-17 | The Penn State Research Foundation | Synthesis of drug nanoparticles by spray drying |
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US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
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ES2051968T3 (es) * | 1988-12-22 | 1994-07-01 | American Cyanamid Co | Metodo para el tratamiento de enfermedad periodontal mediante la liberacion continua de un agente terapeutico a la bolsa periodontal; composicion de materia del mismo y aparato para su administracion. |
IL92344A0 (en) * | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
JPH04247987A (ja) * | 1991-01-18 | 1992-09-03 | Fuji Photo Film Co Ltd | 感熱記録材料 |
YU48420B (sh) * | 1991-03-25 | 1998-07-10 | Hoechst Aktiengesellschaft | Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem |
-
1993
- 1993-10-18 HU HU9401329A patent/HU221308B1/hu not_active IP Right Cessation
- 1993-10-18 CA CA002126685A patent/CA2126685C/en not_active Expired - Fee Related
- 1993-10-18 KR KR1019940702042A patent/KR100225983B1/ko not_active IP Right Cessation
- 1993-10-18 JP JP51051894A patent/JP3523254B2/ja not_active Expired - Fee Related
- 1993-10-18 DE DE59309257T patent/DE59309257D1/de not_active Expired - Fee Related
- 1993-10-18 EP EP93922486A patent/EP0625069B1/de not_active Expired - Lifetime
- 1993-10-18 DK DK93922486T patent/DK0625069T3/da active
- 1993-10-18 AT AT93922486T patent/ATE175132T1/de not_active IP Right Cessation
- 1993-10-18 WO PCT/CH1993/000246 patent/WO1994009898A1/de active IP Right Grant
- 1993-10-18 ES ES93922486T patent/ES2127835T3/es not_active Expired - Lifetime
- 1993-10-26 CN CN93119645A patent/CN1058864C/zh not_active Expired - Fee Related
-
1994
- 1994-06-22 US US08/264,007 patent/US5648096A/en not_active Expired - Fee Related
- 1994-06-23 FI FI943067A patent/FI943067A/fi not_active IP Right Cessation
-
1999
- 1999-02-26 GR GR990400601T patent/GR3029504T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU221308B1 (en) | 2002-09-28 |
GR3029504T3 (en) | 1999-05-28 |
US5648096A (en) | 1997-07-15 |
FI943067A0 (fi) | 1994-06-23 |
DK0625069T3 (da) | 1999-08-30 |
CN1090172A (zh) | 1994-08-03 |
FI943067A (fi) | 1994-06-23 |
CA2126685A1 (en) | 1994-05-11 |
KR100225983B1 (ko) | 1999-10-15 |
WO1994009898A1 (de) | 1994-05-11 |
DE59309257D1 (de) | 1999-02-11 |
HU9401329D0 (en) | 1994-08-29 |
EP0625069B1 (de) | 1998-12-30 |
HUT70418A (en) | 1995-10-30 |
EP0625069A1 (de) | 1994-11-23 |
CN1058864C (zh) | 2000-11-29 |
KR940703713A (ko) | 1994-12-12 |
JP3523254B2 (ja) | 2004-04-26 |
CA2126685C (en) | 2002-07-23 |
ATE175132T1 (de) | 1999-01-15 |
JPH07502686A (ja) | 1995-03-23 |
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