MXPA03010672A - Composicion para el tratamiento regenerativo de enfermedades del cartilago. - Google Patents
Composicion para el tratamiento regenerativo de enfermedades del cartilago.Info
- Publication number
- MXPA03010672A MXPA03010672A MXPA03010672A MXPA03010672A MXPA03010672A MX PA03010672 A MXPA03010672 A MX PA03010672A MX PA03010672 A MXPA03010672 A MX PA03010672A MX PA03010672 A MXPA03010672 A MX PA03010672A MX PA03010672 A MXPA03010672 A MX PA03010672A
- Authority
- MX
- Mexico
- Prior art keywords
- chondropathy
- repairing
- therapeutic compositions
- inhibitor
- pde4
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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Abstract
Se provee una composicion para el tratamiento regenerativo de enfermedades del cartilago, la cual comprende un inhibidor de PDE4 como ingrediente activo, especificamente una composicion que comprende un inhibidor de PDE4 y un polimero biocompatible y biodegradable cuya composicion, cuando se formula en una forma adecuada para administrarse localmente a una region afectada del cartilago, tal como una preparacion de microesferas, puede proveer una composicion farmaceutica que muestra un efecto excelente en el tratamiento regenerativo del cartilago.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001154048 | 2001-05-23 | ||
PCT/JP2002/004930 WO2002094320A1 (fr) | 2001-05-23 | 2002-05-22 | Compositions therapeutiques permettant de reparer la chondropathie |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010672A true MXPA03010672A (es) | 2004-03-02 |
Family
ID=18998464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010672A MXPA03010672A (es) | 2001-05-23 | 2002-05-22 | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
Country Status (10)
Country | Link |
---|---|
US (3) | US20040180900A1 (es) |
EP (1) | EP1389467B1 (es) |
JP (2) | JP4510383B2 (es) |
KR (1) | KR20040007583A (es) |
CN (1) | CN1537018A (es) |
AR (1) | AR034044A1 (es) |
CA (1) | CA2447618A1 (es) |
ES (1) | ES2427930T3 (es) |
MX (1) | MXPA03010672A (es) |
WO (1) | WO2002094320A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002076475A2 (en) * | 2001-03-23 | 2002-10-03 | Bioparken As | Glycosaminoglycan anticoagulants derived from fish |
MXPA03010672A (es) * | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
TWI221838B (en) | 2001-08-09 | 2004-10-11 | Tanabe Seiyaku Co | Pyrazinoisoquinoline compound or naphthalene compound |
FR2876582B1 (fr) * | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
TWI339578B (en) * | 2004-10-29 | 2011-04-01 | Mitsubishi Tanabe Pharma Corp | Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions |
US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
US20080038557A1 (en) * | 2006-08-08 | 2008-02-14 | The Procter & Gamble Company | Process for making collapsible water-containing capsules |
US20100291027A1 (en) * | 2009-05-14 | 2010-11-18 | Jason Campbell | Hyaluronic acid (ha) injection vehicle |
ITPI20090106A1 (it) * | 2009-08-27 | 2011-02-28 | Eros Dinelli | Dispositivo medico per la prevenzione ed il trattamento di condropatie |
WO2011031637A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
WO2011031642A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
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-
2002
- 2002-05-22 MX MXPA03010672A patent/MXPA03010672A/es not_active Application Discontinuation
- 2002-05-22 CA CA002447618A patent/CA2447618A1/en not_active Abandoned
- 2002-05-22 WO PCT/JP2002/004930 patent/WO2002094320A1/ja active Application Filing
- 2002-05-22 EP EP02771771.9A patent/EP1389467B1/en not_active Expired - Lifetime
- 2002-05-22 US US10/478,432 patent/US20040180900A1/en not_active Abandoned
- 2002-05-22 ES ES02771771T patent/ES2427930T3/es not_active Expired - Lifetime
- 2002-05-22 KR KR10-2003-7015147A patent/KR20040007583A/ko not_active Application Discontinuation
- 2002-05-22 JP JP2002591036A patent/JP4510383B2/ja not_active Expired - Fee Related
- 2002-05-22 CN CNA028126475A patent/CN1537018A/zh active Pending
- 2002-05-23 AR ARP020101911A patent/AR034044A1/es not_active Application Discontinuation
-
2007
- 2007-02-16 US US11/707,008 patent/US8252794B2/en not_active Expired - Fee Related
-
2010
- 2010-02-17 JP JP2010032748A patent/JP5112461B2/ja not_active Expired - Fee Related
- 2010-05-18 US US12/782,514 patent/US8399466B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR034044A1 (es) | 2004-01-21 |
JP2010155850A (ja) | 2010-07-15 |
EP1389467A4 (en) | 2007-01-10 |
CA2447618A1 (en) | 2002-11-28 |
US20040180900A1 (en) | 2004-09-16 |
JP5112461B2 (ja) | 2013-01-09 |
US20100226993A1 (en) | 2010-09-09 |
US20070155652A1 (en) | 2007-07-05 |
US8399466B2 (en) | 2013-03-19 |
KR20040007583A (ko) | 2004-01-24 |
CN1537018A (zh) | 2004-10-13 |
EP1389467A1 (en) | 2004-02-18 |
EP1389467B1 (en) | 2013-07-03 |
JP4510383B2 (ja) | 2010-07-21 |
WO2002094320A1 (fr) | 2002-11-28 |
JPWO2002094320A1 (ja) | 2004-09-02 |
US8252794B2 (en) | 2012-08-28 |
ES2427930T3 (es) | 2013-11-04 |
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