KR860008776A - 이식용 조성물 및 그의 제조방법 - Google Patents

이식용 조성물 및 그의 제조방법 Download PDF

Info

Publication number
KR860008776A
KR860008776A KR1019860004040A KR860004040A KR860008776A KR 860008776 A KR860008776 A KR 860008776A KR 1019860004040 A KR1019860004040 A KR 1019860004040A KR 860004040 A KR860004040 A KR 860004040A KR 860008776 A KR860008776 A KR 860008776A
Authority
KR
South Korea
Prior art keywords
water
composition
molecular weight
group
polymer
Prior art date
Application number
KR1019860004040A
Other languages
English (en)
Other versions
KR940000001B1 (ko
Inventor
디. 사라티 모하메드
엔. 시바라마크리쉬난 칼리다이쿠리키
Original Assignee
인터내셔날 미네랄즈 앤드 케미칼 코포레이션
켄네드 제이. 번즈 쥬니어
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인터내셔날 미네랄즈 앤드 케미칼 코포레이션, 켄네드 제이. 번즈 쥬니어 filed Critical 인터내셔날 미네랄즈 앤드 케미칼 코포레이션
Publication of KR860008776A publication Critical patent/KR860008776A/ko
Application granted granted Critical
Publication of KR940000001B1 publication Critical patent/KR940000001B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/07—Microporous membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)

Abstract

내용 없음

Description

이식용 조성물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 거대분자 약물과 수불용성 중합체로 이루어진 핵; 및 유기용매, 수불용성 고분자량 중합체 및 수용성 공극-형성제의 용액으로 핵을 피복시킴으로써 형성된 균질한 공극-형성 외부중합체막으로 구성되는, 거대분자 약물의 조절된 방출을 제공하는 이식용 조성물.
  2. 제1항에 있어서, 거대분자 약물이 천연 또는 재조합 생물활성 단백질 또는 이의 동족체인 조성물.
  3. 제2항에 있어서, 단백질이 천연 돼지 성장호르몬 또는 이의 제조합동족체인 조성물.
  4. 제1항에 있어서, 거대분자 약물이 약 2000이상의 분자량을 갖는 조성물.
  5. 제1항에 있어서, 핵중합체가 폴리락트산, 에틸셀루로오즈 및 폴리카프로락톤으로 이루어진 그룹중에서 선택되는 조성물.
  6. 제1항에 있어서, 수용성 공극-형성제가 디메틸 타트레이트 및 디에틸 타트레이트로 이루어진 그룹중에서 선택되는 조성물.
  7. 제1항에 있어서, 중합체막중의 수불용성 고분자량 중합체가 폴리락트산, 에틸셀룰로오즈 및 폴리카프로락톤으로 이루어진 그룹중에서 선택되는 조성물.
  8. 거대분자 약물과 수불용성 중합체의 혼합물을 펠렛으로 형성시키고; 생성된 펠렛을 유기용매, 수불용성 고분자량 중합체 및 수용성 공극-형성제의 용액으로 피복시킨 후; 유기용매를 증발시킴을 특징으로 하는, 조절 방출 조성물의 제조방법.
  9. 제8항에 있어서, 거대분자 약물이 천연 또는 재조합 생물활성 단백질 또는 이의 동족체인 방법.
  10. 제9항에 있어서, 단백질이 천연 돼지 성장호르몬 또는 이의 재조합 동족체인 방법.
  11. 제8항에 있어서, 거대분자 약물이 약 2000이상의 분자량을 갖는 방법.
  12. 제8항에 있어서, 핵중합체가 폴리락트산, 에틸셀룰로오즈 및 폴리카프로락톤으로 이루어진 그룹중에서 선택되는 방법.
  13. 제8항에 있어서, 수용성 공극-형성제가 디메틸 타트레이트 및 디에틸 타트레이트로 이루어진 그룹중에서 선택되는 방법.
  14. 제8항에 있어서, 중합체막중의 수불용성 고분자량 중합체가 폴리락트산, 에틸셀룰로오즈 및 폴리카프로락톤으로 이루어진 그룹중에서 선택되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860004040A 1985-05-24 1986-05-23 조절 방출 조성물의 제조방법 KR940000001B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US737,629 1985-05-24
US06/737,629 US4666704A (en) 1985-05-24 1985-05-24 Controlled release delivery system for macromolecules
US737629 1985-05-24

Publications (2)

Publication Number Publication Date
KR860008776A true KR860008776A (ko) 1986-12-18
KR940000001B1 KR940000001B1 (ko) 1994-01-05

Family

ID=24964638

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004040A KR940000001B1 (ko) 1985-05-24 1986-05-23 조절 방출 조성물의 제조방법

Country Status (15)

Country Link
US (1) US4666704A (ko)
EP (1) EP0204476B1 (ko)
JP (1) JP2755298B2 (ko)
KR (1) KR940000001B1 (ko)
CN (1) CN1020851C (ko)
AT (1) ATE78155T1 (ko)
AU (1) AU590565B2 (ko)
CA (1) CA1277237C (ko)
DE (1) DE3685992T2 (ko)
DK (1) DK171758B1 (ko)
ES (1) ES8707666A1 (ko)
IE (1) IE59684B1 (ko)
IL (1) IL78895A (ko)
PT (1) PT82635B (ko)
ZA (1) ZA863867B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000022894A (ko) * 1998-09-05 2000-04-25 이승진 생분해성 고분자 미립자형 제제 및 그 제조방법

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786501A (en) * 1985-07-15 1988-11-22 International Minerals & Chemical Corp. Cylindrical implants for the controlled release of growth hormones
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
US5342622A (en) * 1986-05-16 1994-08-30 The State Of Victoria Subdermal biocompatible implants
AU601443B2 (en) * 1986-05-16 1990-09-13 Monash Medical Centre Biocompatible implants
WO1987006828A1 (en) * 1986-05-16 1987-11-19 The State Of Victoria Biocompatible implants
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5073381A (en) * 1988-08-15 1991-12-17 University Of Akron Amphiphilic networks
SE8803822D0 (sv) * 1988-10-26 1988-10-26 Novel dosage form
US5030452A (en) * 1989-01-12 1991-07-09 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
US5108756A (en) * 1989-01-12 1992-04-28 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
US5141748A (en) * 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
AU634529B2 (en) * 1989-03-17 1993-02-25 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CH679207A5 (ko) * 1989-07-28 1992-01-15 Debiopharm Sa
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
ES2062634T3 (es) * 1990-08-30 1994-12-16 Senju Pharma Co Composicion con liberacion controlada del farmaco.
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
GB2306325B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6730349B2 (en) 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
ATE401095T1 (de) * 2000-05-26 2008-08-15 Frohwitter Bernhard Mittel zum erhalten und/oder korrigieren der blutglukosekonzentration
JP2004535431A (ja) * 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
WO2004006976A1 (en) 2002-07-12 2004-01-22 Cook Incorporated Coated medical device
US8750983B2 (en) 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
RS53890B1 (en) * 2004-11-10 2015-08-31 Tolmar Therapeutics, Inc. STABILIZED POLYMER DELIVERY SYSTEM
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
DK2010184T3 (da) * 2006-04-06 2013-03-25 Nupathe Inc Implatanter til behandlingen af dopamin associerede tilstande
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US20210007973A1 (en) * 2016-10-05 2021-01-14 Titan Pharmaceuticals, Inc. Implantable devices for drug delivery with reduced burst release
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス， インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
SG11202005947RA (en) * 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
AU2019275409A1 (en) 2018-05-24 2020-07-16 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987445A (en) * 1958-10-10 1961-06-06 Rohm & Haas Drug composition
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
DE2010416B2 (de) * 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
AR206692A1 (es) * 1972-12-27 1976-08-13 Alza Corp Agente dispensador de liberacion sostenida de substancias activas
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4127127A (en) * 1977-05-23 1978-11-28 Alza Corporation Therapeutic systems made from certain segmented copolyesters
US4148871A (en) * 1977-10-11 1979-04-10 Pitt Colin G Sustained subdermal delivery ofdrugs using poly(ε-caprolactone) and its copolymers
IN152178B (ko) * 1978-05-08 1983-11-05 Pfizer
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
EP0013131A3 (en) * 1978-12-27 1981-01-07 Mundipharma A.G. Pharmaceutical composition in solid dosage form, and process for its production
JPS593963B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
JPS593962B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000022894A (ko) * 1998-09-05 2000-04-25 이승진 생분해성 고분자 미립자형 제제 및 그 제조방법

Also Published As

Publication number Publication date
IE861370L (en) 1986-11-24
CN86104226A (zh) 1987-02-25
IL78895A (en) 1991-01-31
KR940000001B1 (ko) 1994-01-05
US4666704A (en) 1987-05-19
ES8707666A1 (es) 1987-08-16
EP0204476B1 (en) 1992-07-15
PT82635B (pt) 1988-07-29
ZA863867B (en) 1987-01-28
JP2755298B2 (ja) 1998-05-20
ATE78155T1 (de) 1992-08-15
DK171758B1 (da) 1997-05-12
AU590565B2 (en) 1989-11-09
ES555277A0 (es) 1987-08-16
CN1020851C (zh) 1993-05-26
CA1277237C (en) 1990-12-04
DE3685992T2 (de) 1992-12-24
DE3685992D1 (de) 1992-08-20
EP0204476A1 (en) 1986-12-10
PT82635A (en) 1986-06-01
DK243886A (da) 1986-11-25
AU5767286A (en) 1986-11-27
IE59684B1 (en) 1994-03-23
IL78895A0 (en) 1986-09-30
DK243886D0 (da) 1986-05-23
JPS61277629A (ja) 1986-12-08

Similar Documents

Publication Publication Date Title
KR860008776A (ko) 이식용 조성물 및 그의 제조방법
US4806595A (en) Method of preparing antithrombogenic medical materials
Speer et al. Biological effects of residual glutaraldehyde in glutaraldehyde‐tanned collagen biomaterials
US4164559A (en) Collagen drug delivery device
US8512693B2 (en) Self-assembling membranes and related methods thereof
US6951902B2 (en) Two dimensional polymer that generates nitric oxide
DE69718470T2 (de) Verfahren und zubereitungen zum verbessern der bioadhäsiv-eigenschaften von polymeren unter verwendung organischer excipienten
KR930017574A (ko) 중합체 미소캡슐을 함유하는 생물학적 활성 물질의 제조방법
DE3688188T2 (de) Verfahren zur Herstellung einer Formulierung mit verzögerter Freisetzung.
DE69433523D1 (de) Makromolekulare Mikropartikel und Verfahren zur ihrer Herstellung
NO881755D0 (no) Mikrogranulaert preparat.
Kishida et al. Polymer drugs and polymeric drugs X: slow release of 5-fluorouracil from biodegradable poly (γ-glutamic acid) and its benzyl ester matrices
CZ300755B6 (cs) Komplex antagonisty LHRH, zpusob prípravy imobilizovaného peptidového prípravku a lécivo obsahující uvedený komplex
JP2510503B2 (ja) 脳由来細胞増殖因子
KR890007789A (ko) 수용성 펩타이드 및 단백질의 생체분해 가능한 마이크로캡슐의 제조방법 및 이 방법에 의해 수득되는 마이크로캡슐
IE891416L (en) Uncrosslinked hydrogel, process for its preparation and its¹uses as an article for medical and/or surgical purposes such¹as tubes, filaments, films, joints, implants and the like,¹particularly in ophthalmology
KR101866359B1 (ko) 동물 연골 유래 조직을 이용한 가교된 나노섬유 시트 및 이의 제조방법
JP2667688B2 (ja) 蛋白質フイルムの製造法
Hovgaard et al. Evaluation of biodegradable hydrogels for colon‐specific drug delivery
KR850001690A (ko) 조절 펩타이드를 함유하는 서방성 제제의 제조방법
KR910002466A (ko) 안정화 fgf 조성물 및 그의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20000104

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee