DE3685992D1 - System zur kontrollierten freigabe von makromolekuelen. - Google Patents

System zur kontrollierten freigabe von makromolekuelen.

Info

Publication number
DE3685992D1
DE3685992D1 DE8686303949T DE3685992T DE3685992D1 DE 3685992 D1 DE3685992 D1 DE 3685992D1 DE 8686303949 T DE8686303949 T DE 8686303949T DE 3685992 T DE3685992 T DE 3685992T DE 3685992 D1 DE3685992 D1 DE 3685992D1
Authority
DE
Germany
Prior art keywords
macromolecules
controlled release
core
water insoluble
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686303949T
Other languages
English (en)
Other versions
DE3685992T2 (de
Inventor
Mohamad D Shalati
Kallidaikuric Sivaramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Minerals and Chemical Corp
Original Assignee
International Minerals and Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Minerals and Chemical Corp filed Critical International Minerals and Chemical Corp
Application granted granted Critical
Publication of DE3685992D1 publication Critical patent/DE3685992D1/de
Publication of DE3685992T2 publication Critical patent/DE3685992T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/07—Microporous membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)
DE8686303949T 1985-05-24 1986-05-23 System zur kontrollierten freigabe von makromolekuelen. Expired - Fee Related DE3685992T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/737,629 US4666704A (en) 1985-05-24 1985-05-24 Controlled release delivery system for macromolecules

Publications (2)

Publication Number Publication Date
DE3685992D1 true DE3685992D1 (de) 1992-08-20
DE3685992T2 DE3685992T2 (de) 1992-12-24

Family

ID=24964638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686303949T Expired - Fee Related DE3685992T2 (de) 1985-05-24 1986-05-23 System zur kontrollierten freigabe von makromolekuelen.

Country Status (15)

Country Link
US (1) US4666704A (de)
EP (1) EP0204476B1 (de)
JP (1) JP2755298B2 (de)
KR (1) KR940000001B1 (de)
CN (1) CN1020851C (de)
AT (1) ATE78155T1 (de)
AU (1) AU590565B2 (de)
CA (1) CA1277237C (de)
DE (1) DE3685992T2 (de)
DK (1) DK171758B1 (de)
ES (1) ES8707666A1 (de)
IE (1) IE59684B1 (de)
IL (1) IL78895A (de)
PT (1) PT82635B (de)
ZA (1) ZA863867B (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786501A (en) * 1985-07-15 1988-11-22 International Minerals & Chemical Corp. Cylindrical implants for the controlled release of growth hormones
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
US5342622A (en) * 1986-05-16 1994-08-30 The State Of Victoria Subdermal biocompatible implants
AU601443B2 (en) * 1986-05-16 1990-09-13 Monash Medical Centre Biocompatible implants
WO1987006828A1 (en) * 1986-05-16 1987-11-19 The State Of Victoria Biocompatible implants
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5073381A (en) * 1988-08-15 1991-12-17 University Of Akron Amphiphilic networks
SE8803822D0 (sv) * 1988-10-26 1988-10-26 Novel dosage form
US5030452A (en) * 1989-01-12 1991-07-09 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
US5108756A (en) * 1989-01-12 1992-04-28 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
US5141748A (en) * 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
AU634529B2 (en) * 1989-03-17 1993-02-25 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CH679207A5 (de) * 1989-07-28 1992-01-15 Debiopharm Sa
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
ES2062634T3 (es) * 1990-08-30 1994-12-16 Senju Pharma Co Composicion con liberacion controlada del farmaco.
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
GB2306325B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
KR20000022894A (ko) * 1998-09-05 2000-04-25 이승진 생분해성 고분자 미립자형 제제 및 그 제조방법
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6730349B2 (en) 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
ATE401095T1 (de) * 2000-05-26 2008-08-15 Frohwitter Bernhard Mittel zum erhalten und/oder korrigieren der blutglukosekonzentration
JP2004535431A (ja) * 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
WO2004006976A1 (en) 2002-07-12 2004-01-22 Cook Incorporated Coated medical device
US8750983B2 (en) 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
RS53890B1 (en) * 2004-11-10 2015-08-31 Tolmar Therapeutics, Inc. STABILIZED POLYMER DELIVERY SYSTEM
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
DK2010184T3 (da) * 2006-04-06 2013-03-25 Nupathe Inc Implatanter til behandlingen af dopamin associerede tilstande
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US20210007973A1 (en) * 2016-10-05 2021-01-14 Titan Pharmaceuticals, Inc. Implantable devices for drug delivery with reduced burst release
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス， インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
SG11202005947RA (en) * 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
AU2019275409A1 (en) 2018-05-24 2020-07-16 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987445A (en) * 1958-10-10 1961-06-06 Rohm & Haas Drug composition
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
DE2010416B2 (de) * 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
AR206692A1 (es) * 1972-12-27 1976-08-13 Alza Corp Agente dispensador de liberacion sostenida de substancias activas
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4127127A (en) * 1977-05-23 1978-11-28 Alza Corporation Therapeutic systems made from certain segmented copolyesters
US4148871A (en) * 1977-10-11 1979-04-10 Pitt Colin G Sustained subdermal delivery ofdrugs using poly(ε-caprolactone) and its copolymers
IN152178B (de) * 1978-05-08 1983-11-05 Pfizer
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
EP0013131A3 (de) * 1978-12-27 1981-01-07 Mundipharma A.G. Pharmazeutische Zusammensetzung in fester Verabreichungsform und Verfahren zu ihrer Herstellung
JPS593963B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
JPS593962B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same

Also Published As

Publication number Publication date
IE861370L (en) 1986-11-24
CN86104226A (zh) 1987-02-25
IL78895A (en) 1991-01-31
KR940000001B1 (ko) 1994-01-05
US4666704A (en) 1987-05-19
ES8707666A1 (es) 1987-08-16
EP0204476B1 (de) 1992-07-15
PT82635B (pt) 1988-07-29
ZA863867B (en) 1987-01-28
JP2755298B2 (ja) 1998-05-20
ATE78155T1 (de) 1992-08-15
DK171758B1 (da) 1997-05-12
AU590565B2 (en) 1989-11-09
ES555277A0 (es) 1987-08-16
CN1020851C (zh) 1993-05-26
CA1277237C (en) 1990-12-04
DE3685992T2 (de) 1992-12-24
EP0204476A1 (de) 1986-12-10
KR860008776A (ko) 1986-12-18
PT82635A (en) 1986-06-01
DK243886A (da) 1986-11-25
AU5767286A (en) 1986-11-27
IE59684B1 (en) 1994-03-23
IL78895A0 (en) 1986-09-30
DK243886D0 (da) 1986-05-23
JPS61277629A (ja) 1986-12-08

Similar Documents

Publication Publication Date Title
DE3685992D1 (de) System zur kontrollierten freigabe von makromolekuelen.
BR9713150A (pt) Processo para a atualização de localização de uma estação móvel em um sistema de comunicação móvel celular, e, elemento de rede de comunicação móvel.
DE69814885D1 (de) Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis
ATE11153T1 (de) Verbesserte sulfonsaeurehaltige membranen fuer eine elektrolytische zelle.
DE3484222D1 (de) Wundverband aus kunstharz und verfahren zur herstellung.
DK30187D0 (da) Farmaceutisk praeparat til opnaaelse af en hoejviskos hydrogel eller suspension
ES8502158A1 (es) Procedimiento para inmovilizar un material biologico.
DE3762867D1 (de) Mesomorpher polymerwirkstoff, verwendungsfaehig zur nichtlinearoptik.
AU585377B2 (en) Controlled release pharmaceutical composition
DK0932391T3 (da) Fusogen liposomsammensætning og fremgangsmåde
FR2750330B1 (fr) Composition se presentant notamment sous la forme d'emulsion, de gel ou de solution aqueuse, et comprenant un polymere poly(acide 2 -acrylamido 2 -methylpropane sulfonique) reticule
DE69028011T2 (de) Verlängerte Wirkstoffabgabe von kleinen, wasserlöslichen Molekülen
DE3789956T2 (de) Polymere trägerzubereitungen, herstellung und verwendung.
DE3765146D1 (de) Vernetzte karboxylgruppen enthaltende kopolymere, verwendbar als verdickungsmittel in waessrigen systemen und deren herstellung.
ATE320245T1 (de) Filmförmige zubereitung zur biphasigen freisetzung pharmakologisch wirksamer oder anderer substanzen
NO167498C (no) Behandlet, halvgjennomtrengelig polymermembran, fremgangsmaate for fremstilling derav og anvendelse av membranen.
ES2058313T3 (es) Procedimiento para prevenir la formacion de incrustaciones de polimero.
ES2029853T5 (es) Base de unguento y unguento.
ATE205709T1 (de) Polymere ionene als anthelminthika in tieren
DE68907687T2 (de) In einer zur Erhöhung ihrer Löslichkeitsrate geeigneten Form auf polymere Substanzen aufgebrachte schwerlösliche Arzneistoffe.
BR8305158A (pt) Processos para imobilizar uma proteina sobre um suporte polimerico, um hormonio sobre um suporte, uma enzima sobre um suporte, catalase sobre um suporte de pelicula polimerica porosa e oxidase de glicose e catalase sobre um po de polimero poroso
DE60218869D1 (de) Verfahren zur herstellung von pfropf-copolymer membranen
ES2079598T3 (es) Procedimiento para el revestimiento de principios activos con un polimero sensible al ph.
GB8909561D0 (en) Radiation-sensitive composition and use thereof in the preparation of electrochemical ion sensors
ES2106750T3 (es) Polimeros mixtos hidrofilos asi como su empleo en la reprografia.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee