DK0417572T3 - Forlænget frigivelse af små vandopløselige molekyler - Google Patents

Forlænget frigivelse af små vandopløselige molekyler

Info

Publication number
DK0417572T3
DK0417572T3 DK90116768.4T DK90116768T DK0417572T3 DK 0417572 T3 DK0417572 T3 DK 0417572T3 DK 90116768 T DK90116768 T DK 90116768T DK 0417572 T3 DK0417572 T3 DK 0417572T3
Authority
DK
Denmark
Prior art keywords
fluid
biologically active
polymeric matrix
molecules
release
Prior art date
Application number
DK90116768.4T
Other languages
English (en)
Inventor
Bernhard A Dr Sabel
Andrew Freese
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0417572T3 publication Critical patent/DK0417572T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK90116768.4T 1989-09-14 1990-08-31 Forlænget frigivelse af små vandopløselige molekyler DK0417572T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/407,418 US5114719A (en) 1987-04-29 1989-09-14 Extended drug delivery of small, water-soluble molecules

Publications (1)

Publication Number Publication Date
DK0417572T3 true DK0417572T3 (da) 1996-09-02

Family

ID=23612002

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90116768.4T DK0417572T3 (da) 1989-09-14 1990-08-31 Forlænget frigivelse af små vandopløselige molekyler

Country Status (6)

Country Link
US (1) US5114719A (da)
EP (1) EP0417572B1 (da)
AT (1) ATE141047T1 (da)
DE (1) DE69028011T2 (da)
DK (1) DK0417572T3 (da)
ES (1) ES2093625T3 (da)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5601835A (en) * 1987-04-29 1997-02-11 Massachusetts Institute Of Technology Polymeric device for controlled drug delivery to the CNS
WO1993001286A2 (en) * 1991-06-28 1993-01-21 Massachusetts Institute Of Technology Localized oligonucleotide therapy
CA2082411A1 (en) * 1991-06-28 1992-12-29 Robert D. Rosenberg Localized oligonucleotide therapy
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5302397A (en) * 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
ES2150427T3 (es) * 1992-06-02 2000-12-01 Bard Inc C R Procedimiento y dispositivo de implante para el suministro de farmacos a largo plazo.
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5383873A (en) * 1992-12-09 1995-01-24 Regents Of The University Of Minnesota Smooth muscle chemical pacemaker
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5538733A (en) * 1994-07-07 1996-07-23 Willmar Poultry Company, Inc. Method of priming an immune response in a one-day old animal
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
IL112834A (en) * 1995-03-01 2000-12-06 Yeda Res & Dev Pharmaceutical compositions for controlled release of soluble receptors
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
ATE377418T1 (de) 1995-06-07 2007-11-15 Poniard Pharmaceuticals Inc Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
EP0951279A1 (en) * 1997-01-10 1999-10-27 Abbott Laboratories Tablet for the controlled release of active agents
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
AU760408B2 (en) * 1998-04-27 2003-05-15 Surmodics, Inc. Bioactive agent release coating
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
US6682754B2 (en) * 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
ATE323517T1 (de) 2000-08-15 2006-05-15 Surmodics Inc Matrix zur aufnahme von arzneimitteln
AU2002239255B2 (en) * 2000-11-28 2006-06-15 Boston Scientific Limited Method and apparatus for delivery of therapeutic from a delivery matrix
MXPA04006163A (es) * 2001-12-20 2004-11-01 Pharmacia Corp Formas de dosis de liberacion sostenida del orden-cero y metodo de fabricacion de las mismas.
US8685427B2 (en) * 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
HUE039377T2 (hu) * 2002-05-31 2018-12-28 L Molteni & C Dei Fratelli Alitti Soc Di Esercizio S P A Beültethetõ polimer eszköz buprenorfin folytonos kibocsátására
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US8920826B2 (en) * 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US8105652B2 (en) * 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
MXPA05010450A (es) * 2003-03-31 2005-11-04 Titan Pharmaceuticals Inc Dispositivo polimerico implantable para la liberacion prolongada de agonistas de dopamina.
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
JP4824549B2 (ja) * 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
US8637503B2 (en) * 2003-05-16 2014-01-28 Board Of Regents, The University Of Texas System Phenothiazine enantiomers as agents for the prevention of bone loss
US20100285087A1 (en) * 2003-05-16 2010-11-11 The University Of Texas Single phenothiazine enantiomers as agents for the prevention of bone loss
EP1638536A2 (en) * 2003-05-30 2006-03-29 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of nalmefene
CA2563150A1 (en) * 2004-04-06 2005-10-20 Surmodics, Inc. Coating compositions for bioactive agents
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
CA2575988C (en) * 2004-08-04 2014-02-18 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US20080311177A1 (en) 2007-06-14 2008-12-18 Massachusetts Institute Of Technology Self Assembled Films for Protein and Drug Delivery Applications
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
EP2547332B1 (en) 2010-03-16 2018-08-29 Titan Pharmaceuticals, Inc. Heterogeneous implantable devices for drug delivery
US8476221B2 (en) 2011-03-18 2013-07-02 Halimed Pharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders
WO2013163234A1 (en) 2012-04-23 2013-10-31 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
CA2874824C (en) 2012-06-01 2021-10-26 Surmodics, Inc. Apparatus and methods for coating balloon catheters
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
WO2015172153A1 (en) 2014-05-09 2015-11-12 Yale University Topical formulation of hyperbranched polyglycerol-coated particles thereof
US9956323B2 (en) 2014-12-18 2018-05-01 Cook Medical Technologies Llc Medical devices for local bioactive delivery
CN105380909B (zh) * 2015-12-25 2018-07-17 武汉回盛生物科技股份有限公司 一种氟苯尼考可溶性粉及其制备方法
JP2019508037A (ja) 2016-02-16 2019-03-28 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ 標的化遺伝子編集を増強するための組成物およびその使用方法
WO2017143061A1 (en) 2016-02-16 2017-08-24 Yale University Compositions and methods for treatment of cystic fibrosis
KR102272235B1 (ko) 2016-05-12 2021-07-01 머크 샤프 앤드 돔 코포레이션 항바이러스제의 전달을 위한 약물 전달 시스템
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US20210189431A1 (en) 2018-08-10 2021-06-24 Yale University Compositions and methods for embryonic gene editing in vitro
WO2020081279A1 (en) * 2018-10-17 2020-04-23 Dow Global Technologies Llc A coating composition, a coated fabric, a method of making a coated fabric, and an article made from the coated fabric
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2020257779A1 (en) 2019-06-21 2020-12-24 Yale University Hydroxymethyl-modified gamma-pna compositions and methods of use thereof
WO2020257776A1 (en) 2019-06-21 2020-12-24 Yale University Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof
WO2021022161A1 (en) 2019-07-31 2021-02-04 Yale University Compositions and methods for treating sickle cell disease
US10758329B1 (en) 2019-08-20 2020-09-01 Raymond L. Wright, III Hydrating mouth guard
WO2022261115A1 (en) 2021-06-07 2022-12-15 Yale University Peptide nucleic acids for spatiotemporal control of crispr-cas binding

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US153896A (en) * 1874-08-11 Improvement in argand-burners
DE1215291B (de) * 1961-04-07 1966-04-28 Blendax Werke Schneider Co Einrichtung an in Laengsrichtung geteilten, aufklappbaren Giessformen fuer wachsaehnliche Massen
US3518150A (en) * 1966-09-27 1970-06-30 Philip G Patch Devices for bonding thermoplastic filaments
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3851648A (en) * 1973-10-11 1974-12-03 Mead Johnson & Co Zero-order release device
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US3965255A (en) * 1974-05-01 1976-06-22 E. E. Eljim Ecology Ltd. Controlled drug releasing preparations
US4034758A (en) * 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4016880A (en) * 1976-03-04 1977-04-12 Alza Corporation Osmotically driven active agent dispenser
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4278087A (en) * 1980-04-28 1981-07-14 Alza Corporation Device with integrated operations for controlling release of agent
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
JPS57130914A (en) * 1981-02-04 1982-08-13 Agency Of Ind Science & Technol Prolongation of activity retention
US4475916A (en) * 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
NL8401912A (nl) * 1984-06-15 1986-01-02 Tno Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan.
FR2573307B1 (fr) * 1984-11-22 1988-06-10 Virbac Ctre Rech Biolog Implants anabolisants a liberation prolongee
EP0226061B1 (en) * 1985-12-17 1994-02-16 United States Surgical Corporation High molecular weight bioresorbable polymers and implantation devices thereof
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4883666A (en) * 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
ES2054784T3 (es) * 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.

Also Published As

Publication number Publication date
ES2093625T3 (es) 1997-01-01
EP0417572A3 (en) 1991-06-12
US5114719A (en) 1992-05-19
DE69028011T2 (de) 1997-01-23
ATE141047T1 (de) 1996-08-15
EP0417572B1 (en) 1996-08-07
EP0417572A2 (en) 1991-03-20
DE69028011D1 (de) 1996-09-12

Similar Documents

Publication Publication Date Title
DK0417572T3 (da) Forlænget frigivelse af små vandopløselige molekyler
IL78895A (en) Controlled release implant composition for macromolecular drugs
NO171004C (no) Fremgangsmaate for fremstilling av en utleveringsanordningsom i naervaer av en opploesningsvaeske frigir en biologisk aktiv bestanddel ved en i praksis konstant hastighet under en utvidet tidsperiode
CA2029383A1 (en) Swelling modulated polymeric drug delivery device
ATE135906T1 (de) Tabletten mit gesteuerter wirkstoffabgabe
ATE114242T1 (de) Auf quervernetzte polymere aufgebrachte und mit polymerfilmen beschichtete therapeutische zusammensetzungen mit kontrollierter freisetzung von medikamenten und deren herstellungsverfahren.
EP0179023A3 (en) With micro-organisms degradable polypeptide, and its use for the progressive release of medicaments
DE68905722D1 (de) Biologisch abbaubare hydrogel-matrices zur kontrollierten freisetzung pharmakologisch aktiver wirkstoffe.
ATE81970T1 (de) Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe.
UA26402C2 (uk) Порошкоподібhа,hерозчиhhа у воді, абсорбуюча водhі або серозhі рідиhи, а також кров, зшита смола, спосіб її одержаhhя та виріб, абсорбуючий рідиhи
MY102859A (en) A composition for the control of insects.
DE50011177D1 (de) Bioabbaubare blockcopolymere mit modifizierbarer oberfläche
GR3030732T3 (en) Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent.
FR2596399B1 (fr) Nanoparticules a base de polymere ou copolymere methacrylique, procede de preparation, et application comme vecteur de medicament
ES2061475T3 (es) Masa polimerica basica, adhesiva, permeable al principio activo, procedimiento para su obtencion y uso.
EP0325086A3 (en) Novel methods for obtaining therapeutic systems with controlled release of the drug
US4931281A (en) Laminar structure for administering a chemical at a controlled release rate
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
DE69212135D1 (de) Herstellung von homogenen Hydrogel-Copolymeren
KR920002167A (ko) 자가 방출 조절형 인슐린제형
ES2073454T3 (es) Soporte para moleculas biologicamente activas o a su vez biologicamente activo, su procedimiento de preparacion y su aplicacion en biologia.
ES2084867T3 (es) Comprimido de aspirina de matriz tamponada.
NL7901919A (en) Polymer compsn. contg. physiologically active cpd. - with controlled release mixt., prepd. by polymerising monomers with radiation at below room temp. (NL 11.9.79)
TH10364EX (th) กรรมวิธีสำหรับเตรียมอนุภาคที่มีขนาดสม่ำเสมอซึ่งควบคุมอยู่ในช่วง 1 ถึง 50 ไมโครเมตร