ATE141047T1 - Verlängerte wirkstoffabgabe von kleinen, wasserlöslichen molekülen - Google Patents
Verlängerte wirkstoffabgabe von kleinen, wasserlöslichen molekülenInfo
- Publication number
- ATE141047T1 ATE141047T1 AT90116768T AT90116768T ATE141047T1 AT E141047 T1 ATE141047 T1 AT E141047T1 AT 90116768 T AT90116768 T AT 90116768T AT 90116768 T AT90116768 T AT 90116768T AT E141047 T1 ATE141047 T1 AT E141047T1
- Authority
- AT
- Austria
- Prior art keywords
- fluid
- biologically active
- polymeric matrix
- water
- molecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/407,418 US5114719A (en) | 1987-04-29 | 1989-09-14 | Extended drug delivery of small, water-soluble molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE141047T1 true ATE141047T1 (de) | 1996-08-15 |
Family
ID=23612002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90116768T ATE141047T1 (de) | 1989-09-14 | 1990-08-31 | Verlängerte wirkstoffabgabe von kleinen, wasserlöslichen molekülen |
Country Status (6)
Country | Link |
---|---|
US (1) | US5114719A (de) |
EP (1) | EP0417572B1 (de) |
AT (1) | ATE141047T1 (de) |
DE (1) | DE69028011T2 (de) |
DK (1) | DK0417572T3 (de) |
ES (1) | ES2093625T3 (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5601835A (en) * | 1987-04-29 | 1997-02-11 | Massachusetts Institute Of Technology | Polymeric device for controlled drug delivery to the CNS |
JPH07501204A (ja) * | 1991-06-28 | 1995-02-09 | マサチューセッツ インスティテュート オブ テクノロジー | 局所的オリゴヌクレオチド療法 |
EP0558697A1 (de) * | 1991-06-28 | 1993-09-08 | Massachusetts Institute Of Technology | Lokale oligonukleotiden Behandlung |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5302397A (en) * | 1991-11-19 | 1994-04-12 | Amsden Brian G | Polymer-based drug delivery system |
DE69329407T2 (de) * | 1992-06-02 | 2001-05-03 | Bard Inc C R | Verfahren und Implantatvorrichtung für Langzeitwirkstoffabgabe |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6395494B1 (en) | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5770609A (en) * | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US5383873A (en) * | 1992-12-09 | 1995-01-24 | Regents Of The University Of Minnesota | Smooth muscle chemical pacemaker |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
US5538733A (en) * | 1994-07-07 | 1996-07-23 | Willmar Poultry Company, Inc. | Method of priming an immune response in a one-day old animal |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
IL112834A (en) * | 1995-03-01 | 2000-12-06 | Yeda Res & Dev | Pharmaceutical compositions for controlled release of soluble receptors |
US6017496A (en) | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
US6416714B1 (en) | 1995-04-25 | 2002-07-09 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
US5874214A (en) | 1995-04-25 | 1999-02-23 | Irori | Remotely programmable matrices with memories |
US5751629A (en) * | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US6331273B1 (en) | 1995-04-25 | 2001-12-18 | Discovery Partners International | Remotely programmable matrices with memories |
US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
AU6277396A (en) * | 1995-06-07 | 1996-12-30 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
SE9601421D0 (sv) * | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
JP5170723B2 (ja) * | 1997-01-10 | 2013-03-27 | アボット・ラボラトリーズ | 活性薬剤の制御放出用錠剤 |
AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
ES2179646T3 (es) * | 1998-04-27 | 2003-01-16 | Surmodics Inc | Revestimiento que libera un agente bioactivo. |
US6319510B1 (en) | 1999-04-20 | 2001-11-20 | Alayne Yates | Gum pad for delivery of medication to mucosal tissues |
US6682754B2 (en) * | 1999-11-24 | 2004-01-27 | Willmar Poultry Company, Inc. | Ovo delivery of an immunogen containing implant |
MXPA03001406A (es) | 2000-08-15 | 2004-05-04 | Surmodics Inc | Matriz de incorporacion de medicamento. |
CA2429943A1 (en) * | 2000-11-28 | 2002-06-06 | Boston Scientific Limited | Method and apparatus for delivery of therapeutic from a delivery matrix |
US20030133982A1 (en) * | 2001-12-20 | 2003-07-17 | Heimlich John M. | Zero-order sustained release dosage forms and method of making same |
US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
US8685427B2 (en) * | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
PT2561860T (pt) * | 2002-05-31 | 2018-05-08 | Titan Pharmaceuticals Inc | Dispositivo polimérico implantável para a libertação prolongada de buprenorfina |
US7097850B2 (en) * | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US20030232087A1 (en) * | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
US8920826B2 (en) * | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
US8105652B2 (en) * | 2002-10-24 | 2012-01-31 | Massachusetts Institute Of Technology | Methods of making decomposable thin films of polyelectrolytes and uses thereof |
US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
CN102772357B (zh) * | 2003-03-31 | 2014-12-31 | 泰坦医药品公司 | 用于持续释放多巴胺受体激动剂的可植入聚合物装置 |
EP1633320A2 (de) * | 2003-05-02 | 2006-03-15 | SurModics, Inc. | Implantierbares system zur kontrollierten freisetzung eines bioaktiven wirkstoffs |
US8246974B2 (en) * | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
US20100285087A1 (en) * | 2003-05-16 | 2010-11-11 | The University Of Texas | Single phenothiazine enantiomers as agents for the prevention of bone loss |
US8637503B2 (en) * | 2003-05-16 | 2014-01-28 | Board Of Regents, The University Of Texas System | Phenothiazine enantiomers as agents for the prevention of bone loss |
WO2004110400A2 (en) * | 2003-05-30 | 2004-12-23 | Titan Pharmaceuticals, Inc. | Implantable polymeric device for sustained release of nalmefene |
US7541048B2 (en) * | 2004-04-06 | 2009-06-02 | Surmodics, Inc. | Coating compositions for bioactive agents |
US20060083772A1 (en) * | 2004-04-06 | 2006-04-20 | Dewitt David M | Coating compositions for bioactive agents |
WO2006078320A2 (en) * | 2004-08-04 | 2006-07-27 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
WO2008157372A2 (en) | 2007-06-14 | 2008-12-24 | Massachusetts Institute Of Technology | Self assembled films for protein and drug delivery applications |
EP2222281B1 (de) | 2007-12-20 | 2018-12-05 | Evonik Corporation | Verfahren zur herstellung von mikropartikeln mit geringer restlösemittelmenge |
US9198875B2 (en) * | 2008-08-17 | 2015-12-01 | Massachusetts Institute Of Technology | Controlled delivery of bioactive agents from decomposable films |
KR101914119B1 (ko) | 2010-03-16 | 2018-11-02 | 타이탄 파머슈티컬즈 인코퍼레이티드 | 약물 전달용 이종 이식가능 장치 |
US8476221B2 (en) | 2011-03-18 | 2013-07-02 | Halimed Pharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders |
US10278927B2 (en) | 2012-04-23 | 2019-05-07 | Massachusetts Institute Of Technology | Stable layer-by-layer coated particles |
US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
MX351261B (es) | 2012-06-01 | 2017-10-06 | Surmodics Inc | Aparato y método para recubrir catéteres con globo. |
WO2014134029A1 (en) | 2013-02-26 | 2014-09-04 | Massachusetts Institute Of Technology | Nucleic acid particles, methods and use thereof |
US9463244B2 (en) | 2013-03-15 | 2016-10-11 | Massachusetts Institute Of Technology | Compositions and methods for nucleic acid delivery |
EP3140269B1 (de) | 2014-05-09 | 2023-11-29 | Yale University | Hyperverzweigte polyglycerolbeschichtete partikel und verfahren zur herstellung und verwendung davon |
US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
US9956323B2 (en) | 2014-12-18 | 2018-05-01 | Cook Medical Technologies Llc | Medical devices for local bioactive delivery |
CN105380909B (zh) * | 2015-12-25 | 2018-07-17 | 武汉回盛生物科技股份有限公司 | 一种氟苯尼考可溶性粉及其制备方法 |
JP2019508037A (ja) | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーYale Universit | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
WO2017143061A1 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions and methods for treatment of cystic fibrosis |
US11400186B2 (en) | 2016-05-12 | 2022-08-02 | Merck Sharp & Dohme Llc | Drug delivery system for the delivery of antiviral agents |
WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
US20210189431A1 (en) | 2018-08-10 | 2021-06-24 | Yale University | Compositions and methods for embryonic gene editing in vitro |
WO2020081279A1 (en) * | 2018-10-17 | 2020-04-23 | Dow Global Technologies Llc | A coating composition, a coated fabric, a method of making a coated fabric, and an article made from the coated fabric |
US11628466B2 (en) | 2018-11-29 | 2023-04-18 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
WO2021002984A1 (en) | 2019-05-30 | 2021-01-07 | Massachusetts Institute Of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
US20220243211A1 (en) | 2019-06-21 | 2022-08-04 | Yale University | Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof |
US20220372474A1 (en) | 2019-06-21 | 2022-11-24 | Yale University | Hydroxymethyl-modified gamma-pna compositions and methods of use thereof |
WO2021022161A1 (en) | 2019-07-31 | 2021-02-04 | Yale University | Compositions and methods for treating sickle cell disease |
US10758329B1 (en) | 2019-08-20 | 2020-09-01 | Raymond L. Wright, III | Hydrating mouth guard |
US20240279687A1 (en) | 2021-06-07 | 2024-08-22 | Yale University | Peptide nucleic acids for spatiotemporal control of crispr-cas binding |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US153896A (en) * | 1874-08-11 | Improvement in argand-burners | ||
DE1215291B (de) * | 1961-04-07 | 1966-04-28 | Blendax Werke Schneider Co | Einrichtung an in Laengsrichtung geteilten, aufklappbaren Giessformen fuer wachsaehnliche Massen |
US3518150A (en) * | 1966-09-27 | 1970-06-30 | Philip G Patch | Devices for bonding thermoplastic filaments |
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
US3965255A (en) * | 1974-05-01 | 1976-06-22 | E. E. Eljim Ecology Ltd. | Controlled drug releasing preparations |
US4034758A (en) * | 1975-09-08 | 1977-07-12 | Alza Corporation | Osmotic therapeutic system for administering medicament |
US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4016880A (en) * | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
US4391797A (en) * | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
US4278087A (en) * | 1980-04-28 | 1981-07-14 | Alza Corporation | Device with integrated operations for controlling release of agent |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
JPS57130914A (en) * | 1981-02-04 | 1982-08-13 | Agency Of Ind Science & Technol | Prolongation of activity retention |
US4475916A (en) * | 1982-03-18 | 1984-10-09 | Merck & Co., Inc. | Osmotic drug delivery system |
NL8401912A (nl) * | 1984-06-15 | 1986-01-02 | Tno | Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan. |
FR2573307B1 (fr) * | 1984-11-22 | 1988-06-10 | Virbac Ctre Rech Biolog | Implants anabolisants a liberation prolongee |
EP0226061B1 (de) * | 1985-12-17 | 1994-02-16 | United States Surgical Corporation | Bioresorbierbare Polymere von hohem Molekulargewicht und Implantate davon |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
ATE86484T1 (de) * | 1987-08-08 | 1993-03-15 | Akzo Nv | Kontrazeptives implantat. |
-
1989
- 1989-09-14 US US07/407,418 patent/US5114719A/en not_active Expired - Lifetime
-
1990
- 1990-08-31 AT AT90116768T patent/ATE141047T1/de not_active IP Right Cessation
- 1990-08-31 DE DE69028011T patent/DE69028011T2/de not_active Expired - Lifetime
- 1990-08-31 ES ES90116768T patent/ES2093625T3/es not_active Expired - Lifetime
- 1990-08-31 EP EP90116768A patent/EP0417572B1/de not_active Expired - Lifetime
- 1990-08-31 DK DK90116768.4T patent/DK0417572T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP0417572A2 (de) | 1991-03-20 |
EP0417572B1 (de) | 1996-08-07 |
EP0417572A3 (en) | 1991-06-12 |
ES2093625T3 (es) | 1997-01-01 |
DE69028011D1 (de) | 1996-09-12 |
DK0417572T3 (da) | 1996-09-02 |
DE69028011T2 (de) | 1997-01-23 |
US5114719A (en) | 1992-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |