DE245535T1 - Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. - Google Patents
Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.Info
- Publication number
- DE245535T1 DE245535T1 DE198686106725T DE86106725T DE245535T1 DE 245535 T1 DE245535 T1 DE 245535T1 DE 198686106725 T DE198686106725 T DE 198686106725T DE 86106725 T DE86106725 T DE 86106725T DE 245535 T1 DE245535 T1 DE 245535T1
- Authority
- DE
- Germany
- Prior art keywords
- polymer matrix
- active ingredient
- active substances
- delivering active
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 title claims 8
- 239000013543 active substance Substances 0.000 title claims 4
- 239000011159 matrix material Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000004480 active ingredient Substances 0.000 claims 5
- 229940088623 biologically active substance Drugs 0.000 claims 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003016 pheromone Substances 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
- C08G67/04—Polyanhydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (8)
1. Verfahren zur Abgabe eines Wirkstoffes bei Bedarf, das umfaßt:
Einbettten des Wirkstoffes innerhalb einer Polymermatrix,
Umgeben des Wirkstoffes und der Polymermatrix mit einem flüssigen Medium, und
Aussetzen der Polymermatrix der Ultraschal1energie, wodurch
die Polymermatrix resorbiert und der Wirkstoff aus der
Matrix freigegeben wird.
2. Verfahren nach Anspruch 1, worin die Polymermatrix und der
Wirkstoff in vivo implantiert werden und der Wirkstoff eine biologisch aktive Substanz ist.
3. Verfahren nach einem der Ansprüche 1 oder 2, worin die
Polymermatrix ein Polyanhydrid ist.
4. Verfahren nach einem der Ansprüche 1 oder 2, worin die Polymermatrix ein Copolymer von Äthylen und Vinylacetat ist
5. Verfahren nach Anspruch 2, worin die biologisch aktive Substanz ein Arzneimittel ist.
6. Verfahren nach Anspruch 2, worin die biologisch aktive
Substanz Insulin ist.
7. Verfahren nach Anspruch 1, worin der Wirkstoff ein Duftstoff
ist.
8. Verfahren nach Anspruch 1, worin der Wirkstoff ein Pheromon ist.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/633,366 US4657543A (en) | 1984-07-23 | 1984-07-23 | Ultrasonically modulated polymeric devices for delivering compositions |
CA000507996A CA1291064C (en) | 1984-07-23 | 1986-04-30 | Ultrasonically modulated polymeric devices for delivering drug compositions |
EP86106725A EP0245535B1 (de) | 1984-07-23 | 1986-05-16 | Durch Ultraschall gesteuerte polymere Vorrichtungen zur Wirkstoffabgabe |
Publications (1)
Publication Number | Publication Date |
---|---|
DE245535T1 true DE245535T1 (de) | 1989-03-30 |
Family
ID=39628920
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686106725T Expired - Lifetime DE3685958T2 (de) | 1984-07-23 | 1986-05-16 | Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. |
DE198686106725T Pending DE245535T1 (de) | 1984-07-23 | 1986-05-16 | Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686106725T Expired - Lifetime DE3685958T2 (de) | 1984-07-23 | 1986-05-16 | Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. |
Country Status (4)
Country | Link |
---|---|
US (1) | US4657543A (de) |
EP (1) | EP0245535B1 (de) |
CA (1) | CA1291064C (de) |
DE (2) | DE3685958T2 (de) |
Families Citing this family (100)
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WO2016201136A1 (en) | 2015-06-10 | 2016-12-15 | Ekos Corporation | Ultrasound catheter |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3474777A (en) * | 1966-02-10 | 1969-10-28 | Amp Inc | Method of administering therapeutic agents |
US3464413A (en) * | 1967-05-26 | 1969-09-02 | United Merchants & Mfg | Medical bandages |
US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4182750A (en) * | 1977-04-21 | 1980-01-08 | Sullivan Thomas E | Bloodcompatible functional polymers |
US4249531A (en) * | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
US4468220A (en) * | 1982-04-05 | 1984-08-28 | Milliken Research Corporation | Low flow constant rate pump |
-
1984
- 1984-07-23 US US06/633,366 patent/US4657543A/en not_active Expired - Lifetime
-
1986
- 1986-04-30 CA CA000507996A patent/CA1291064C/en not_active Expired
- 1986-05-16 DE DE8686106725T patent/DE3685958T2/de not_active Expired - Lifetime
- 1986-05-16 EP EP86106725A patent/EP0245535B1/de not_active Expired
- 1986-05-16 DE DE198686106725T patent/DE245535T1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0245535A1 (de) | 1987-11-19 |
EP0245535B1 (de) | 1992-07-08 |
DE3685958T2 (de) | 1993-01-14 |
US4657543A (en) | 1987-04-14 |
CA1291064C (en) | 1991-10-22 |
DE3685958D1 (de) | 1992-08-13 |
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