ATE81970T1 - Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe. - Google Patents

Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe.

Info

Publication number
ATE81970T1
ATE81970T1 AT88202760T AT88202760T ATE81970T1 AT E81970 T1 ATE81970 T1 AT E81970T1 AT 88202760 T AT88202760 T AT 88202760T AT 88202760 T AT88202760 T AT 88202760T AT E81970 T1 ATE81970 T1 AT E81970T1
Authority
AT
Austria
Prior art keywords
carbidopa
controlled release
levodopa
polymer
treatment
Prior art date
Application number
AT88202760T
Other languages
English (en)
Inventor
Robert E Dempski
Scott A Reines
Edward C Scholtz
Donald W Nibbelink
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26829626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE81970(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE81970T1 publication Critical patent/ATE81970T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
AT88202760T 1987-12-11 1988-12-02 Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe. ATE81970T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13160187A 1987-12-11 1987-12-11
US07/223,861 US4832957A (en) 1987-12-11 1988-07-25 Controlled release combination of carbidopa/levodopa
EP88202760A EP0320051B1 (de) 1987-12-11 1988-12-02 Carbidopa-Levodopa-Zusammensetzung mit gesteuerter Freigabe

Publications (1)

Publication Number Publication Date
ATE81970T1 true ATE81970T1 (de) 1992-11-15

Family

ID=26829626

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88202760T ATE81970T1 (de) 1987-12-11 1988-12-02 Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe.

Country Status (15)

Country Link
US (1) US4832957A (de)
EP (1) EP0320051B1 (de)
JP (1) JPH0667830B2 (de)
KR (1) KR890009377A (de)
AT (1) ATE81970T1 (de)
AU (1) AU616449B2 (de)
CA (1) CA1318602C (de)
DE (1) DE3875705T2 (de)
DK (1) DK170515B1 (de)
ES (1) ES2052691T3 (de)
GR (1) GR3006220T3 (de)
HK (1) HK7997A (de)
IE (1) IE61547B1 (de)
IL (1) IL88563A0 (de)
PT (1) PT89157B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
JP2653061B2 (ja) * 1986-12-27 1997-09-10 武田薬品工業株式会社 新規ポリペプチドおよびその製造法
US5601835A (en) * 1987-04-29 1997-02-11 Massachusetts Institute Of Technology Polymeric device for controlled drug delivery to the CNS
DE3933000A1 (de) * 1989-10-03 1991-04-11 Int Pharma Agentur Erosionsgesteuertes wirkstoff-freigabesystem und verfahren zu seiner herstellung
US5006344A (en) * 1989-07-10 1991-04-09 E. R. Squibb & Sons, Inc. Fosinopril tablet formulations
CA2037178A1 (en) * 1990-02-28 1991-08-29 Albert Walter Brzeczko Deprenyl/l-dopa/carbidopa pharmaceutical composition
DE4101873C2 (de) * 1991-01-23 1993-12-09 Isis Pharma Gmbh Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände
US5624960A (en) * 1991-01-23 1997-04-29 Isis Pharma Gmbh Orally administrable drugs for the treatment of central dopamine deficiency conditions
HU209564B (en) * 1991-01-30 1994-07-28 Egyt Gyogyszervegyeszeti Gyar Process for producing rapide tablets containing levodopa and carbidopa
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
DE4226753A1 (de) * 1992-08-13 1994-02-17 Basf Ag Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
SE9203594D0 (sv) * 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
FR2725624B1 (fr) * 1994-10-14 1997-01-17 Jouveinal Inst Rech Procede de preparation de formes pharmaceutiques a liberation controlee
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
US6210710B1 (en) * 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
JP2003508420A (ja) 1999-09-02 2003-03-04 ノストラム・ファーマスーティカルズ・インコーポレイテッド 経口投与に適した、制御された放出の経口用量
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
BR0309113A (pt) * 2002-04-11 2005-02-01 Ranbaxy Lab Ltd Composições farmacêuticas de liberação controlada de carbidopa e levodopa e processo para a preparação das mesmas
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
JP2006506362A (ja) * 2002-10-11 2006-02-23 デポメド・ディベロップメント・リミテッド 胃内保持型レボドパデリバリー形態
ITMI20030827A1 (it) * 2003-04-18 2004-10-19 Unihart Corp Composizione farmaceutica contenente l'associazione levodopa/carbidopa.
ES2273271T5 (es) * 2003-05-14 2013-05-21 Aptalis Pharma Limited Composición de liberación controlada de fármaco resistente a la tensión mecánica in vivo
DE10346981A1 (de) * 2003-10-09 2005-05-04 Constr Res & Tech Gmbh Verfahren zur Herstellung einer homogenen, niedrig-viskosen und Langzeit-stabilen Polymer-Dispersion in Mineralölen
CA2553156A1 (en) * 2003-10-20 2005-05-12 Teva Pharmaceutical Industries Ltd. Composition and dosage form for sustained effect of levodopa
US8007826B2 (en) 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition
US8354437B2 (en) 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20060159753A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Matrix type sustained-release preparation containing basic drug or salt thereof
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
BRPI0518396A2 (pt) * 2004-12-27 2008-11-18 Eisai R&D Man Co Ltd mÉtodo para estabilizaÇço de droga anti-demÊncia
US20070003621A1 (en) * 2005-06-23 2007-01-04 Spherics, Inc. Dosage forms for movement disorder treatment
WO2007013830A1 (en) * 2005-07-26 2007-02-01 Portela & Ca. S.A. Nitrocatechol derivatives as comt inhibitors
US20070275060A1 (en) * 2005-08-05 2007-11-29 Osmotica Costa Rica Sociedad Anonima Extended release solid pharmaceutical composition containing carbidopa and levodopa
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
KR100838053B1 (ko) * 2005-10-25 2008-06-12 중앙대학교 산학협력단 시토크롬 피450 85 에이 2 및 이의 이용
US20070178149A1 (en) * 2005-11-07 2007-08-02 Moshe Flashner-Barak Levodopa compositions
WO2007055329A1 (ja) 2005-11-11 2007-05-18 Asahi Kasei Chemicals Corporation 徐放性固形製剤
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
KR100756977B1 (ko) * 2006-09-28 2007-09-07 한국전자통신연구원 휴대 인터넷 망과 인터넷 프로토콜 멀티미디어 서브시스템연동망에서 단말의 핸드오버 방법 및 장치
US20100316712A1 (en) * 2006-12-22 2010-12-16 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
EP2105133A1 (de) 2007-01-15 2009-09-30 Kissei Pharmaceutical Co., Ltd. Herstellung schwebender intragastraler levodopa mit verzögerter freisetzung
KR100892220B1 (ko) * 2007-07-02 2009-04-07 순천대학교 산학협력단 근사기법을 이용한 태양광 발전의 mppt 제어시스템
EP2234963B1 (de) 2007-12-28 2020-04-08 Impax Laboratories, LLC Levodopa-formulierungen mit gesteuerter freisetzung und ihre verwendung
US9161911B2 (en) * 2008-08-15 2015-10-20 Depomed, Inc. Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders
EP2515864A4 (de) * 2009-12-23 2013-09-11 Psivida Inc Vorrichtung mit verzögerter freisetzung
EP2508174A1 (de) 2011-04-06 2012-10-10 Ljiljana Sovic Brkicic Pharmazeutische Zusammensetzung
US20160022573A1 (en) * 2013-03-13 2016-01-28 Neuroderm, Ltd. Method for treatment of parkinson's disease
MX369315B (es) 2013-10-07 2019-11-05 Impax Laboratories Inc Formulaciones muco-adhesivas de liberacion controlada de levodopa y/o esteres de levodopa y sus usos.
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
DK3116475T3 (da) 2014-03-13 2020-12-07 Neuroderm Ltd Dopa-decarboxylasehæmmersammensætninger
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
US11464756B1 (en) 2017-05-19 2022-10-11 Jerry Darm Mecuna pruriens, L-DOPA and 5-HTP based dietary supplements, pharmaceutical formulations and uses thereof
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
CN115737584A (zh) * 2022-11-25 2023-03-07 石家庄四药有限公司 一种卡左双多巴缓释片及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29892A (en) * 1860-09-04 Spring-bedstead
US3632739A (en) * 1969-12-29 1972-01-04 Sandoz Ag Solid sustained release pharmaceutical preparation
US3769424A (en) 1970-10-01 1973-10-30 Merck & Co Inc Composition and method of treating dopamine deficiency in brain tissue
FR2211213B1 (de) * 1972-12-26 1976-04-23 Montagne Noire Prod Chim
US3995058A (en) * 1973-12-12 1976-11-30 Miles Laboratories, Inc. Treatment of ethanol withdrawal symptoms with levodopa
DE2513940A1 (de) * 1975-03-29 1976-10-14 Merck Patent Gmbh Pharmazeutische zubereitung
US4389415A (en) * 1978-01-24 1983-06-21 Merck & Co., Inc. Method of treating hypertension
US4190672A (en) * 1978-09-01 1980-02-26 Stanley Fahn Method and compositions of treating Parkinsonisms with levodopa and 3',4'-dihydroxy-2-methylisopropiophenone
US4173626A (en) * 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
US4469693A (en) * 1980-02-25 1984-09-04 Ayerst, Mckenna & Harrison Inc. 2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives
US4469694A (en) * 1980-02-25 1984-09-04 Ayerst, Mckenna & Harrison Inc. 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives
US4469695A (en) * 1980-02-25 1984-09-04 Ayerst, Mckenna & Harrison, Inc. 2-(4-Hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives
US4329356A (en) * 1980-10-31 1982-05-11 Eli Lilly And Company Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane
US4413012A (en) * 1981-06-01 1983-11-01 Merrell Toraude Et Compagnie Method for treating depression
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
EP0082880B1 (de) * 1981-07-08 1986-06-11 Key Pharmaceuticals, Inc. Polymerische diffusionsmatritze propranolol enthaltend
US4424235A (en) * 1981-09-14 1984-01-03 Hoffmann-La Roche Inc. Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor
JPS5852219A (ja) * 1981-09-22 1983-03-28 Sumitomo Chem Co Ltd パ−キンソン病治療剤
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4446138A (en) * 1982-02-10 1984-05-01 Pack Howard M Method and composition for reducing weight
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4440740A (en) * 1982-04-26 1984-04-03 Merck & Co., Inc. α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
JPS6067420A (ja) * 1983-09-22 1985-04-17 Sumitomo Chem Co Ltd 精神運動興奮抑制剤
JPS61100526A (ja) * 1984-10-22 1986-05-19 Kyowa Hakko Kogyo Co Ltd 持続性ドパミン経黒剤
NZ220599A (en) * 1986-06-16 1990-10-26 Merck & Co Inc Controlled release oral dosage formulation of carbidopa and levodopa
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
IL110896A0 (en) * 1994-01-31 1994-11-28 Loral Qualcomm Satellite Serv Active transmit phases array antenna with amplitude taper

Also Published As

Publication number Publication date
AU616449B2 (en) 1991-10-31
JPH0667830B2 (ja) 1994-08-31
KR890009377A (ko) 1989-08-01
DK685888D0 (da) 1988-12-09
JPH02209A (ja) 1990-01-05
GR3006220T3 (de) 1993-06-21
DK170515B1 (da) 1995-10-09
ES2052691T3 (es) 1994-07-16
HK7997A (en) 1997-01-24
CA1318602C (en) 1993-06-01
DK685888A (da) 1989-07-25
IL88563A0 (en) 1989-07-31
PT89157A (pt) 1989-12-29
US4832957A (en) 1989-05-23
IE61547B1 (en) 1994-11-16
EP0320051A1 (de) 1989-06-14
DE3875705T2 (de) 1993-05-13
AU2673388A (en) 1989-06-15
PT89157B (pt) 1993-06-30
IE883679L (en) 1989-06-11
DE3875705D1 (de) 1992-12-10
EP0320051B1 (de) 1992-11-04

Similar Documents

Publication Publication Date Title
ATE81970T1 (de) Carbidopa-levodopa-zusammensetzung mit gesteuerter freigabe.
ES2018548B3 (es) Composicion de carbidopa/levodopa de liberacion controlada.
NO951592L (no) Fremgangsmåte for fremstilling av et transdermalt terapeutisk system
ATE77962T1 (de) Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen.
EP0279977A3 (de) Transdermale Verabreichung von Progesteron, Östradiolestern und deren Mischungen
DE69031879T2 (de) Pharmazeutisches Mittel zur Behandlung von mit Herpes-Zoster assoziierten Schmerzen und von postherpetischen Neuralgien mittels lokaler Anwendung von Lokalanästhetika
ES2039437T3 (es) Liberacion controlada de polipeptidos macromoleculares.
ATE173162T1 (de) Medizinische vorrichtung zur verabreichung von aktivsubstanzen oder arzneistoffen in sehr niedriger dosis, insbesondere von homöopatischen arzneistoffen
YU49390A (sh) Postupak za izradu transdermalnog terapijskog sistema sa stupnjevitim otpuštanjem aktivne materije
IL89603A (en) Reservoir for controlled active substance delivery, apparatus containing the same and method for the manufacture and use of the apparatus
EP0235259A4 (de) Transdermale arzneimitteleinzeldosis gegen angina und verfahren zu ihrer verabreichung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time