ES2039437T5 - Liberacion controlada de polipeptidos macromoleculares. - Google Patents

Liberacion controlada de polipeptidos macromoleculares.

Info

Publication number
ES2039437T5
ES2039437T5 ES87304570T ES87304570T ES2039437T5 ES 2039437 T5 ES2039437 T5 ES 2039437T5 ES 87304570 T ES87304570 T ES 87304570T ES 87304570 T ES87304570 T ES 87304570T ES 2039437 T5 ES2039437 T5 ES 2039437T5
Authority
ES
Spain
Prior art keywords
controlled release
macromolecular polypeptides
macromolecular
polypeptides
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87304570T
Other languages
English (en)
Other versions
ES2039437T3 (es
Inventor
Deborah Ann Eppstein
Brian Bloor Schryver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25348017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2039437(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2039437T3 publication Critical patent/ES2039437T3/es
Publication of ES2039437T5 publication Critical patent/ES2039437T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

CONSISTE EN UN SISTEMA DE LIBERACION DE UN AGENTE ACTIVO PARA LA ADMINISTRACION CONTROLADA DE POLIPEPTIDOS MACROMOLECULARES QUE COMPRENDE UNA MICROSUSPENSION DE COMPONENTES SOLUBLES EN AGUA Y UNA MATRIZ DE POLILACTIDO.
ES87304570T 1986-05-23 1987-05-22 Liberacion controlada de polipeptidos macromoleculares. Expired - Lifetime ES2039437T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/866,625 US4962091A (en) 1986-05-23 1986-05-23 Controlled release of macromolecular polypeptides

Publications (2)

Publication Number Publication Date
ES2039437T3 ES2039437T3 (es) 1993-10-01
ES2039437T5 true ES2039437T5 (es) 2003-06-16

Family

ID=25348017

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87304570T Expired - Lifetime ES2039437T5 (es) 1986-05-23 1987-05-22 Liberacion controlada de polipeptidos macromoleculares.

Country Status (10)

Country Link
US (1) US4962091A (es)
EP (1) EP0251476B2 (es)
JP (1) JP2594560B2 (es)
AT (1) ATE85214T1 (es)
AU (1) AU608225B2 (es)
CA (1) CA1293443C (es)
DE (1) DE3783958T3 (es)
ES (1) ES2039437T5 (es)
HK (1) HK38997A (es)
NZ (1) NZ220403A (es)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102872A (en) * 1985-09-20 1992-04-07 Cetus Corporation Controlled-release formulations of interleukin-2
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5633002A (en) * 1988-10-04 1997-05-27 Boehringer Ingelheim Gmbh Implantable, biodegradable system for releasing active substance
US5288487A (en) * 1989-02-28 1994-02-22 Morinaga Milk Industry Co., Ltd. Human monocyte-macrophage-CSF preparations
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CH679207A5 (es) * 1989-07-28 1992-01-15 Debiopharm Sa
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
CH681425A5 (es) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
US5252342A (en) * 1990-03-05 1993-10-12 The Regents Of The University Of California Enhancement of anti-neoplastic drug efficacy using EGF
US5597798A (en) * 1990-03-05 1997-01-28 The Regents Of The University Of California Taxol and epidermal growth factor used to enhance treatment of ovarian cancer
US5270057A (en) * 1990-03-20 1993-12-14 Akzo N.V. Stabilized gonadotropin containing preparations
DK0528978T3 (da) * 1990-05-16 2003-02-17 Southern Res Inst Mikrokapsler til reguleret afgivelse og deres anvendelse i stimulering af nervefibervækst
US6517859B1 (en) * 1990-05-16 2003-02-11 Southern Research Institute Microcapsules for administration of neuroactive agents
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
IE913264A1 (en) * 1990-10-01 1992-04-08 Res Dev Foundation Synergism of TNF and IL-4
WO1992006112A1 (en) * 1990-10-09 1992-04-16 Sri International Activated ctap and analogs thereof and their use
NO302481B1 (no) * 1990-10-16 1998-03-09 Takeda Chemical Industries Ltd Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CA2097426A1 (en) * 1990-11-30 1992-05-31 Bruce M. Cameron, Sr. Method for the diagnosis of chronic lower back and cervical pain
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
ZA92304B (en) * 1991-01-16 1992-09-30 Schering Corp Use of interleukin-10 in adoptive immunotherapy of cancer
YU48420B (sh) * 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem
WO1992019263A1 (en) * 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1993015722A1 (en) * 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
CA2129514A1 (en) * 1992-03-12 1993-09-16 M. Amin Khan Controlled released acth containing microspheres
US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
ZA932273B (en) * 1992-03-30 1993-11-26 Alza Corp Additives for bioerodible polymers to regulate degradation
AU3941493A (en) * 1992-03-30 1993-11-08 Alza Corporation Viscous suspensions of controlled-release drug particles
US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US20030035845A1 (en) * 1992-06-11 2003-02-20 Zale Stephen E. Composition for sustained release of non-aggregated erythropoietin
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US7105158B1 (en) * 1992-11-16 2006-09-12 The Corporation Of Mercer University Methods of administering microencapsulated materials for immune modulated diseases
EP0674506B1 (en) 1992-12-02 2000-08-23 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
PT686045E (pt) * 1993-02-23 2001-04-30 Genentech Inc Estabilizacao por excipientes de polipeptidos tratados com solventes organicos
WO1994023699A1 (en) * 1993-04-19 1994-10-27 Medisorb Technologies International L.P. Long-acting treatment by slow-release delivery of antisense oligodeoxyribonucleotides from biodegradable microparticles
WO1996040098A2 (en) 1995-06-07 1996-12-19 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
CA2162586C (en) * 1993-05-13 2006-01-03 David J. Grainger Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US5635216A (en) * 1993-12-16 1997-06-03 Eli Lilly And Company Microparticle compositions containing peptides, and methods for the preparation thereof
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5411940A (en) * 1993-09-29 1995-05-02 Alcon Laboratories, Inc. Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma
CA2149657A1 (en) * 1993-09-29 1995-04-06 Billie M. York Compositions containing growth factors and antiplastic agents
JPH07100178A (ja) * 1993-10-01 1995-04-18 Sadako Ueda 天然炭酸カルシウム入浴剤
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6913767B1 (en) * 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
CA2175049A1 (en) * 1993-10-28 1995-05-04 Timothy Ringeisen Improved process and device for treating and healing a bone void
CA2178902A1 (en) * 1993-12-14 1995-06-22 Drew Pardoll Controlled release of pharmaceutically active substances for immunotherapy
ES2156932T3 (es) * 1993-12-23 2001-08-01 Rmf Dictagene Sa Microparticulas cargadas con antigeno y preparados farmaceuticos que contienen estas microparticulas.
PT754032E (pt) * 1994-04-08 2002-05-31 Atrix Lab Inc Composicoes liquidas para difusao
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5681568A (en) * 1994-08-19 1997-10-28 Cambridge Neuroscience, Inc. Device for delivery of substances and methods of use thereof
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
JPH08215516A (ja) * 1995-02-10 1996-08-27 Hiroshi Kaneko 浴槽水の浄化・活性化フィルタ−
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
JP2000507912A (ja) * 1995-08-31 2000-06-27 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 作用剤の徐放性組成物
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5843462A (en) 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
ATE227980T1 (de) 1996-03-28 2002-12-15 Takeda Chemical Industries Ltd Zubereitung mit verzögerter freisetzung und deren herstellung
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
ES2221019T3 (es) 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. Preparacion de liberacion mantenida.
EP0959873B1 (en) 1996-12-20 2006-03-01 ALZA Corporation Gel composition and methods
EP1037663A2 (en) 1997-12-16 2000-09-27 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
CN1301172A (zh) 1998-03-20 2001-06-27 武田药品工业株式会社 生理活性多肽的缓释制剂及其生产
US7128927B1 (en) 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
WO2000012062A1 (en) * 1998-09-02 2000-03-09 Point Biomedical Corporation Local delivery of medications to the heart
SI1112095T1 (en) * 1998-09-11 2003-04-30 Gerhard Dr. Schmidmaier Biologically active implants
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
DE10008880A1 (de) * 1999-02-19 2000-08-24 Bioserv Ag Bioabbaubare Komposite zur Herstellung von Mikrokapseln
AU3556400A (en) * 1999-03-17 2000-10-04 Novartis Ag Pharmaceutical compositions
WO2000062759A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Dry, mouldable drug formulation
DE19932603A1 (de) * 1999-07-13 2001-01-25 Gruenenthal Gmbh Wirkstoffhaltiger Mehrschichtfilm aus in situ vernetzten hydrophilen Polymeren
US7678087B2 (en) * 1999-09-29 2010-03-16 Heska Corporation Equine intranasal delivery system
US6398774B1 (en) 1999-09-29 2002-06-04 Heska Corporation Intranasal delivery system
PT1398038E (pt) * 2000-02-08 2007-02-28 Allergan Inc Composições farmacêuticas de toxina botulínica
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20030138460A1 (en) * 2000-02-08 2003-07-24 Allergan, Inc Methods of treating animals with botulinum toxin pharmaceutical compositions
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US7037332B2 (en) 2000-03-15 2006-05-02 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6927223B1 (en) 2000-05-26 2005-08-09 Washington State University Research Foundation Use of serotonin agents for adjunct therapy in the treatment of cancer
AU2001281729A1 (en) * 2000-07-14 2002-01-30 Novo-Nordisk A/S Method of moulding a pharmaceutical composition in a packaging material
EP1343478B1 (en) 2000-12-21 2007-10-10 Alrise Biosystems GmbH Induced phase transition method for the production of microparticles containing hydrophilic active agents
EP1353685A2 (en) * 2000-12-29 2003-10-22 PBL Biomedical Laboratories Controlled release pharmaceutical systems
MXPA03010672A (es) 2001-05-23 2004-03-02 Tanabe Seiyaku Co Composicion para el tratamiento regenerativo de enfermedades del cartilago.
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS PROMOTING THE GUISON OF A BONE FRACTURE
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
DE10146251A1 (de) * 2001-09-20 2003-04-17 Gruenenthal Gmbh Vorrichtung zur Herstellung eines pharmazeutischen Films
US20030186271A1 (en) * 2001-11-19 2003-10-02 Robin Hwang Pharmaceutical compositions in particulate form
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
ES2207387B1 (es) * 2002-02-28 2005-07-16 Consejo Sup. Investig. Cientificas Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas.
CA2476410C (en) 2002-03-01 2013-09-24 Celltech R & D, Inc. Methods to increase or decrease bone density
NZ536965A (en) 2002-05-31 2007-02-23 Titan Pharmaceuticals Inc Nonerodible polymeric matrix with buprenorphine encapsulated for the treatment of opiate addiction and pain
EP1523310A2 (en) 2002-07-09 2005-04-20 The Scripps Research Institute Method to inhibit ischemia and reperfusion injury
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
AU2003297282A1 (en) * 2002-11-14 2004-06-15 Cornell Research Foundation, Inc. Protection of cardiac myocardium
DE60334246D1 (de) 2002-11-21 2010-10-28 Celltech R & D Inc Modulieren von immunantworten
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
US7094785B1 (en) 2002-12-18 2006-08-22 Cornell Research Foundation, Inc. Method of treating polycythemia vera
US20070026069A1 (en) * 2003-03-28 2007-02-01 Shastri Venkatram P Biommetic hierarchies using functionalized nanoparticles as building blocks
MXPA05010450A (es) * 2003-03-31 2005-11-04 Titan Pharmaceuticals Inc Dispositivo polimerico implantable para la liberacion prolongada de agonistas de dopamina.
JP4699991B2 (ja) * 2003-04-02 2011-06-15 アレス トレーディング ソシエテ アノニム 非イオン性界面活性剤を一緒に伴うfsh及びlhの液体医薬組成物
WO2004098634A2 (en) * 2003-04-30 2004-11-18 Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health Protein arginine n-methyltransferase 2 (prmt-2)
JP4871124B2 (ja) * 2003-06-20 2012-02-08 アレス トレーディング ソシエテ アノニム 凍結乾燥fsh/lh製剤
US20050053612A1 (en) * 2003-08-20 2005-03-10 Granstein Richard D. Nucleotide regulation of immune responses
JP2007504244A (ja) * 2003-09-05 2007-03-01 ザ スクリプス リサーチ インスティテュート アテローム硬化症および/または心血管性疾患の処置および予防のためのコレステロールのオゾン化産物
US20050209141A1 (en) * 2003-10-17 2005-09-22 Silver Randi B Mast cell-derived renin
US7164008B2 (en) * 2003-11-17 2007-01-16 University Of Iowa Research Foundation Isolated complexes of endotoxin and MD-2
JP2007527539A (ja) * 2004-03-05 2007-09-27 ザ スクリプス リサーチ インスティテュート ハイスループットグリカンマイクロアレイ
US8613934B2 (en) * 2004-03-22 2013-12-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cellular and viral inactivation
TW200605910A (en) 2004-04-30 2006-02-16 Orbus Medical Technologies Inc Medical device with coating for capturing genetically-altered cells and methods for using same
US20060194726A1 (en) * 2004-05-25 2006-08-31 Rueger David C Methods of treating cartilage defects
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
JP2008522951A (ja) * 2004-07-19 2008-07-03 ベイラー・カレツジ・オブ・メデイシン サイトカインシグナル伝達調節物質の調節および免疫療法のための応用
DK1927597T3 (en) 2004-08-18 2017-02-13 Novabiotics Ltd ANTIBACTERIAL PEPTIDES
WO2006068758A2 (en) * 2004-11-19 2006-06-29 The Scripps Research Institute Detection, prevention and treatment of breast cancer
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
WO2006076504A2 (en) * 2005-01-13 2006-07-20 University Of Iowa Research Foundation Sialic acid permease system
US20060194740A1 (en) * 2005-02-25 2006-08-31 Ulevitch Richard J NOD1 as an anti-tumor agent
CN101501055B (zh) * 2005-06-23 2016-05-11 贝勒医学院 负性免疫调节因子的调节和免疫疗法应用
EP2357191A3 (en) 2005-12-22 2011-08-24 Novabiotics Limited Cyclic antimicrobial peptides
EP1986676A4 (en) * 2006-02-15 2009-11-04 Univ Yale Inc COMPOSITIONS AND METHODS USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) PEPTIDE FRAGMENTS
US8088396B2 (en) * 2006-03-01 2012-01-03 University Of Iowa Research Foundation Isolated complexes of endotoxin and modified MD-2
US20070265170A1 (en) * 2006-05-15 2007-11-15 Ola Blixt Detection, prevention and treatment of ovarian cancer
US8137682B2 (en) * 2006-09-20 2012-03-20 University Of Iowa Research Foundation Isolated complexes of covalently cross-linked endotoxin and modified MD-2
US8846073B2 (en) 2006-12-19 2014-09-30 Allergan, Inc. Low temperature processes for making cyclic lipid implants for intraocular use
CN101678082B (zh) 2007-03-26 2013-06-19 再生医药有限公司 使用cxcl9和抗cxcl9抗体促进骨髓保护和再生的方法
WO2008150477A2 (en) 2007-05-31 2008-12-11 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health N-acetyl mannosamine as a therapeutic agent
ES2549122T3 (es) 2007-05-31 2015-10-23 University Of Iowa Research Foundation Reducción de toxicidad por interferencia de ARN desviada de su diana
JP2011505144A (ja) * 2007-11-30 2011-02-24 ベイラー カレッジ オブ メディシン 樹状細胞ワクチン組成物およびその使用
TWI352717B (en) * 2007-12-11 2011-11-21 Ind Tech Res Inst A tenacity adjuster, a biodegradable material comp
US20110112079A1 (en) * 2008-01-09 2011-05-12 Thomas Craig J Phosphodiesterase inhibitors
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
AR067447A1 (es) * 2008-07-03 2009-10-14 Monte Verde S A Un procedimiento para preparar una composicion farmaceutica que contiene los proincipios activos glucosamina y meloxicam y el uso de dicha asociacion para el tratamiento de patologias degenerativas osteo-articulares
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8603496B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8858912B2 (en) 2008-10-31 2014-10-14 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US9056047B2 (en) 2008-10-31 2015-06-16 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8256233B2 (en) * 2008-10-31 2012-09-04 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8545857B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100178038A1 (en) * 2009-01-12 2010-07-15 Mediatek Inc. Video player
WO2011038002A1 (en) 2009-09-22 2011-03-31 Yale University Immunogenic epitopes as targets for universal cancer vaccines
GB201016733D0 (en) 2010-10-05 2010-11-17 Novabiotics Ltd Compounds and their use
US8632839B2 (en) * 2010-10-19 2014-01-21 Covidien Lp Methods of forming self-supporting films for delivery of therapeutic agents
EP2468269A1 (en) 2010-11-26 2012-06-27 Universitätsklinikum Münster Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation
WO2012076842A1 (en) 2010-12-09 2012-06-14 University Of Durham Synthetic retinoids for control of cell differentiation
GB201021186D0 (en) 2010-12-14 2011-01-26 Novabiotics Ltd Composition
WO2012109667A1 (en) 2011-02-12 2012-08-16 University Of Iowa Research Foundation Therapeutic compounds
CA2846486C (en) 2011-07-12 2019-08-20 Philadelphia Health & Education Corporation Novel clostridium difficile dna vaccine
WO2013013178A1 (en) 2011-07-21 2013-01-24 Kansas State University Research Foundation Sesquiterpenes for antifungal applications
WO2014011663A1 (en) 2012-07-09 2014-01-16 Board Of Trustees Of Michigan State University Inhibitors of bacterial diguanylate cyclase
US9512425B2 (en) 2012-10-23 2016-12-06 Cornell University Inhibiting migration of cancer cells
DK2925297T3 (en) * 2012-11-02 2017-10-02 Cytuvax COMPOSITION COMPREHENSIVE CYTOCHINE MACROAGGERATES
EP2951199A4 (en) 2013-01-31 2016-07-20 Univ Jefferson Fusion proteins for the modulation of regulatory and effector T cells
US8957044B2 (en) 2013-03-01 2015-02-17 Wake Forest University Health Sciences Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)
EP3030548B1 (en) 2013-08-09 2019-03-27 The Scripps Research Institute Transcriptome-wide design of selective, bioactive small molecules targeting rna
EP3039126B1 (en) 2013-08-26 2019-10-09 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Small molecule cellular reprogramming to generate neuronal cells
WO2015038704A1 (en) 2013-09-11 2015-03-19 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Compositions for preparing cardiomyocytes
CN107075514A (zh) 2014-05-20 2017-08-18 衣阿华大学研究基金会 亨廷顿氏病的治疗化合物
WO2016040347A2 (en) 2014-09-08 2016-03-17 University Of Iowa Research Foundation Microrna inhibitor system and methods of use thereof
US9758781B2 (en) 2014-09-30 2017-09-12 University Of Iowa Research Foundation Methods to prevent and treat autosomal dominant non-syndromic hearing loss
WO2016137963A1 (en) 2015-02-25 2016-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sialylation-increasing therapies for diseases associated with oxidative stress
WO2016196507A1 (en) 2015-05-29 2016-12-08 University Of Iowa Research Foundation Methods of delivery of transgenes for treating brain diseases
WO2016199146A1 (en) * 2015-06-09 2016-12-15 B. G. Negev Technologies And Applications Ltd A controlled release system for pulmonary delivery of surfactant protein d
EP3331988B1 (en) 2015-08-07 2023-09-20 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Chemical reprogramming to generate neuronal cells
EP4036220A1 (en) * 2015-12-17 2022-08-03 Life Technologies Corporation Pellets used in cell culture and methods of making thereof
US10273476B2 (en) 2016-04-30 2019-04-30 University Of Iowa Research Foundation MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
US10994006B2 (en) 2016-07-08 2021-05-04 The Scripps Research Institute Desensitizing mast cells by co-presentation of antigens with high affinity mast cell siglec ligands
WO2018224813A1 (en) 2017-06-06 2018-12-13 Novabiotics Limited Use of cysteamine compositions
US11154606B2 (en) 2017-07-05 2021-10-26 Arizona Board Of Regents On Behalf Of Arizona State University Vaccine for prevention of necrotic enteritis in poultry
CA3069515A1 (en) 2017-07-10 2019-01-17 Cornell University Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment
US11452764B2 (en) 2017-07-21 2022-09-27 University Of North Dakota Inhibiting FAK-AKT interaction to inhibit metastasis
BR112021003897A2 (pt) 2018-08-30 2021-05-25 Tenaya Therapeutics, Inc. reprogramação de células cardíacas com miocarina e asci1
AU2019360638A1 (en) 2018-10-17 2021-06-03 Novabiotics Limited Dosage regime
US20220089670A1 (en) 2018-12-28 2022-03-24 University Of Rochester Gene Therapy for BEST1 Dominant Mutations
WO2021007515A1 (en) 2019-07-11 2021-01-14 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with micrornas and other factors
US20230037822A1 (en) 2019-10-28 2023-02-09 The Scripps Research Institute Immune cell receptor antibodies conjugated to high affinity siglec-ligands
WO2021142230A1 (en) 2020-01-10 2021-07-15 Cornell University Methods to alter latency in ebv+ malignancies
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
JP2024503719A (ja) 2021-01-19 2024-01-26 ザ ジェイ. デビッド グラッドストーン インスティテューツ、 ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ. デビッド グラッドストーン ヒトt細胞の機能を強化するための遺伝子活性化標的
WO2023250249A1 (en) 2022-06-23 2023-12-28 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Hmgb1 inhibitors for treatment of apoe4-related tauopathies including alzheimer's disease
WO2024097418A2 (en) 2022-11-03 2024-05-10 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Gene activation and interference targets for exhaustion/dysfunction-resistant t cell products and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419340A (en) * 1969-03-24 1983-12-06 University Of Delaware Controlled release of anticancer agents from biodegradable polymers
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
US4512972A (en) * 1980-06-30 1985-04-23 Kureha Chemical Industry Co., Ltd. Nasal preparation and processes for their production
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US4678809A (en) * 1985-02-01 1987-07-07 Michael Phillips Injectable fomulations of disulfiram for the treatment of alcoholism

Also Published As

Publication number Publication date
EP0251476B1 (en) 1993-02-03
CA1293443C (en) 1991-12-24
DE3783958T2 (de) 1993-06-09
JP2594560B2 (ja) 1997-03-26
DE3783958D1 (de) 1993-03-18
HK38997A (en) 1997-04-04
AU7333287A (en) 1987-11-26
DE3783958T3 (de) 2003-08-07
EP0251476B2 (en) 2002-11-27
EP0251476A1 (en) 1988-01-07
ES2039437T3 (es) 1993-10-01
JPS632930A (ja) 1988-01-07
NZ220403A (en) 1990-06-26
ATE85214T1 (de) 1993-02-15
AU608225B2 (en) 1991-03-28
US4962091A (en) 1990-10-09

Similar Documents

Publication Publication Date Title
ES2039437T3 (es) Liberacion controlada de polipeptidos macromoleculares.
DK288987D0 (da) Et afgivelsessystem til doseringsformerne forhalet afgivelse, samt dettes fremstilling
DE3771272D1 (de) Pulsierendes arzneistoffabgabesystem.
IT8521922A0 (it) Sistema di somministrazione di farmaci.
DE68911473D1 (de) Arzneimittelformulierungen.
DE3886965D1 (de) Zubereitungen zur gesteuerten Wirkstofffreisetzung.
MX9203755A (es) Dispositivo de suministro iontoforetico de drogas o agentes terapeuticos, dotado de un adhesivo de electrotransporte.
NO882897D0 (no) Avleveringssystem for legemidler.
DK528988D0 (da) Laegemiddelafgivelsessystem
ES2016620B3 (es) Sistema para liberar medicamentos con bioaceptabilidad mejorada.
DK304485A (da) Faste laegemiddelpraeparater med dihydropyridiner samt fremstilling deraf
IL82674A (en) Passive drug delivery system
DE3869670D1 (de) Latex fuer die immobilisierung von physiologisch aktiven verbindungen und reaktiver latex, der diesen latex verwendet.
NO892764D0 (no) Medikamentell administreringsform for droevtyggere.
IT8722501A0 (it) Formulazioni farmaceutiche per somministrazione transdermica.
DE3867086D1 (de) Benzothiepino(5,4-c)pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
EP0380989A3 (en) Plaster for transdermal administration
ES2019634B3 (es) Terapia con clorfeniramina.
DE68921180D1 (de) Apparat für die Verabreichung von Medikamenten für die Veterinärmedizin.
DE3871159D1 (de) Pharmazeutische und tieraerztliche zusammensetzungen.
IT8523530V0 (it) Dispositivo perfezionato per somministrazione medicinali iniettabili.
DE3773322D1 (de) Pharmazeutische zubereitungen mit heilender aktivitaet.
EP0305194A3 (en) Veterinary composition
DE68916622D1 (de) Verabreichungssystem für vorgefüllte Spritze.
ATE75613T1 (de) 17-benzylspartein-derivate enthaltende positiv inotrop wirksame pharmazeutische zubereitungen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 251476

Country of ref document: ES