ES2156932T3 - Microparticulas cargadas con antigeno y preparados farmaceuticos que contienen estas microparticulas. - Google Patents

Microparticulas cargadas con antigeno y preparados farmaceuticos que contienen estas microparticulas.

Info

Publication number
ES2156932T3
ES2156932T3 ES95903221T ES95903221T ES2156932T3 ES 2156932 T3 ES2156932 T3 ES 2156932T3 ES 95903221 T ES95903221 T ES 95903221T ES 95903221 T ES95903221 T ES 95903221T ES 2156932 T3 ES2156932 T3 ES 2156932T3
Authority
ES
Spain
Prior art keywords
microparticles
antigen
biodegradable
potentiation
immunological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903221T
Other languages
English (en)
Inventor
Bruno Gander
Giampietro Corradin
Ying Men
Claudio Thomasin
Hans Peter Merkle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RMF Dictagene SA
Original Assignee
RMF Dictagene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RMF Dictagene SA filed Critical RMF Dictagene SA
Application granted granted Critical
Publication of ES2156932T3 publication Critical patent/ES2156932T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA POTENCIACION DE RESPUESTA INMUNOLOGICA EN ANTIGENOS SINTETICOS O DE INGENIERIA GENETICA DISPONIENDO DE BAJA CAPACIDAD INMUNOLOGICA. EL ANTIGENO SE ENCUENTRA EMBEBIDO DENTRO DE PARTICULAS BIODEGRADABLES, ESTANDO DISPERSAS ESTAS MICROPARTICULAS CARGADAS CON ANTIGENO EN UN MEDIO BIODEGRADABLE QUE SE DESENCADENA CUANDO ES ADMINISTRADO DE FORMA PARENTERAL EN UN ANTICUERPO POTENCIADO, CON RESPUESTA T{SUB,H} LINFOCITO Y RESPUESTA T{SUB,C} - LINFOCITO, EN COMPARACION CON UNA SOLUCION DE ANTIGENO ACUOSA. LA EXTENSION DE LA POTENCIACION INMUNOLOGICA ES AL MENOS COMPARABLE CON LA OBTENIDA POR MEDIO DE COMPOSICIONES IFA. LOS EPITOPES LINEALES B - T{SUB,T} - CELULA, EPITOPES LINEALES T{SUB,C} - CELULA, DIMEROS Y MULTIMEROS DE TALES EPITOPES, ASI COMO SUS MEZCLAS SON UTILIZADOS COMO ANTIGENOS DE BAJA CAPACIDAD INMUNOLOGICA. LAS MICROPARTICULAS SE BASAN EN BIOPOLIMEROS BIODEGRADABLES TALES COMO POLIESTER, POLIANHIDRIDO, POLIORTOESTER. MEDIANTE MEZCLADO DE MICROPARTICULAS CONDIFERENTE CAPACIDAD DE HUMECTACION, CAPACIDAD DE HINCHAMIENTO, LIBERACION Y TIEMPO DE BIODEGRADACION, SE CONSIGUE LA POTENCIACION MAS INTENSA EN DISPOSICION INMUNOLOGICA MAS LARGA. ESTE PROCESO ES UTILIZABLE PARA LA INMUNIZACION DE SERES HUMANOS Y ANIMALES CONTRA ENFERMEDADES ORIGINADAS PRO VIRUS, BACTERIAS, PROTOZOOS O CELULAS TUMORALES.
ES95903221T 1993-12-23 1994-12-23 Microparticulas cargadas con antigeno y preparados farmaceuticos que contienen estas microparticulas. Expired - Lifetime ES2156932T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH384993 1993-12-23

Publications (1)

Publication Number Publication Date
ES2156932T3 true ES2156932T3 (es) 2001-08-01

Family

ID=4264801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903221T Expired - Lifetime ES2156932T3 (es) 1993-12-23 1994-12-23 Microparticulas cargadas con antigeno y preparados farmaceuticos que contienen estas microparticulas.

Country Status (12)

Country Link
US (1) US6596278B2 (es)
EP (1) EP0686030B1 (es)
JP (1) JPH08507088A (es)
KR (1) KR100372375B1 (es)
CN (1) CN1120809A (es)
AT (1) ATE199316T1 (es)
AU (1) AU1217395A (es)
CA (1) CA2156718A1 (es)
DE (1) DE59409668D1 (es)
DK (1) DK0686030T3 (es)
ES (1) ES2156932T3 (es)
WO (1) WO1995017167A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
WO1997017063A1 (en) 1995-11-09 1997-05-15 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6977074B2 (en) * 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
DE69834494T2 (de) * 1997-07-10 2007-03-01 Mannkind Corp., Valencia Vorrichtung zur induktion einer ctl-antwort
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
WO2000012124A1 (en) 1998-09-01 2000-03-09 Elan Corporation, Plc Oral vaccine compositions
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
EP2351576A1 (en) * 2004-12-29 2011-08-03 Mannkind Corporation Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs
CA2623197A1 (en) * 2005-09-22 2007-03-29 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
US20070092547A1 (en) * 2005-10-24 2007-04-26 Birnbaum Jay E Method for treating/controlling/killing fungi and bacteria
AU2008207025B2 (en) * 2007-01-15 2012-08-23 Glaxosmithkline Biologicals Sa Vaccine
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
US9408906B2 (en) 2010-06-04 2016-08-09 Flow Pharma, Inc. Peptide particle formulation
CN102901814B (zh) * 2012-07-12 2014-11-26 浙江大学 莠去津分子印迹金标试纸条及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599230A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US5762965A (en) * 1984-03-16 1998-06-09 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradble-biocompatible microspheres
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5008116A (en) * 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
KR960005137B1 (ko) * 1989-11-13 1996-04-22 노바 파머수티컬 코포레이션 물질 전달용 리포스피어
WO1992019263A1 (en) * 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
FR2695563B1 (fr) * 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
WO1994015635A1 (en) * 1993-01-11 1994-07-21 Dana-Farber Cancer Institute Inducing cytotoxic t lymphocyte responses
US5879687A (en) * 1994-04-22 1999-03-09 Corixa Corporation Methods for enhancement of protective immune responses
PT991403E (pt) 1997-01-30 2003-08-29 Chiron Corp Uso de microparticulas com antigenio adsorvido para estimular respostas imunes
EP1009386B1 (en) 1997-08-29 2005-08-31 Corixa Corporation Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof
ATE215385T1 (de) 1997-12-16 2002-04-15 Chiron Corp Verwendung von mikropartikeln mit submikron öl/wasser emulsionen
EP1107783B1 (en) 1998-09-01 2006-04-05 ELAN CORPORATION, Plc Method for inducing a cell-mediated immune response and parenteral vaccine formulations therefor

Also Published As

Publication number Publication date
EP0686030B1 (de) 2001-02-28
ATE199316T1 (de) 2001-03-15
KR960700692A (ko) 1996-02-24
WO1995017167A1 (de) 1995-06-29
US6596278B2 (en) 2003-07-22
CN1120809A (zh) 1996-04-17
JPH08507088A (ja) 1996-07-30
DE59409668D1 (de) 2001-04-05
CA2156718A1 (en) 1995-06-29
KR100372375B1 (ko) 2003-04-21
DK0686030T3 (da) 2001-06-25
AU1217395A (en) 1995-07-10
US20020041879A1 (en) 2002-04-11
EP0686030A1 (de) 1995-12-13

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