ES2042292T3 - Dispositivo de administracion de proteinas macromoleculares por liberacion controlada. - Google Patents

Dispositivo de administracion de proteinas macromoleculares por liberacion controlada.

Info

Publication number
ES2042292T3
ES2042292T3 ES199090905065T ES90905065T ES2042292T3 ES 2042292 T3 ES2042292 T3 ES 2042292T3 ES 199090905065 T ES199090905065 T ES 199090905065T ES 90905065 T ES90905065 T ES 90905065T ES 2042292 T3 ES2042292 T3 ES 2042292T3
Authority
ES
Spain
Prior art keywords
water
controlled release
macromolecular
macromolecular proteins
nucleum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES199090905065T
Other languages
English (en)
Inventor
Kallidaikuruchi N. Sivaramakrishnan
Lindy F. Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Veterinary Inc
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Application granted granted Critical
Publication of ES2042292T3 publication Critical patent/ES2042292T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN DISPOSITIVO DE SUMINISTRO DE LIBERACION CONTROLADA PARA PROTEINAS MACROMOLECULARES QUE COMPRENDE UNA CAPSULA EXTERNA SOLUBLE EN AGUA QUE ENVUELVE COMPLETAMENTE UN COMPARTIMENTO INTERNO QUE CONTIENE UNA PLURALIDAD DE PERLITAS NO UNIFORMES. LAS PERLITAS COMPRENDEN UN CUERPO DE CERA ROMPIBLE QUE ENVUELVE COMPLETAMENTE UNA MATRIZ DE NUCLEO QUE CONTIENE LAS PROTEINAS MACROMOLECULARES Y "AGENTES DE NUCLEO" OPCIONALES TAL COMO EXCIPIENTES, ESTABILIZADORES, LIGANTES, SURFACTANTES, CONSERVANTES, O MEZCLAS DE ESTOS Y SIMILARES. LA CAPSULA EXTERNA SOLUBLE EN AGUA SE DISUELVE CUANDO EL DISPOSITIVO ES ADMINISTRADO A UN ANIMAL Y SIMULTANEAMENTE EXPONE SUSTANCIALMENTE TODAS LAS CUENTITAS A UN MEDIO ACUOSO. CADA CUENTITA ABSORBE FLUIDO DEL MEDIO Y SEPARADAMENTE SE ROMPE A LO LARGO DE UN PERIODO PROLONGADO PROPORCIONANDO ASI LA PROTEINA MACROMOLECULAR AL ANIMAL.
ES199090905065T 1989-03-17 1990-03-13 Dispositivo de administracion de proteinas macromoleculares por liberacion controlada. Expired - Lifetime ES2042292T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32474089A 1989-03-17 1989-03-17

Publications (1)

Publication Number Publication Date
ES2042292T3 true ES2042292T3 (es) 1993-12-01

Family

ID=23264894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES199090905065T Expired - Lifetime ES2042292T3 (es) 1989-03-17 1990-03-13 Dispositivo de administracion de proteinas macromoleculares por liberacion controlada.

Country Status (9)

Country Link
EP (1) EP0463061B1 (es)
JP (1) JPH04504122A (es)
AT (1) ATE90203T1 (es)
AU (1) AU634529B2 (es)
DE (1) DE69001898T2 (es)
DK (1) DK0463061T3 (es)
ES (1) ES2042292T3 (es)
NO (1) NO913649D0 (es)
WO (1) WO1990011070A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ286242A (en) * 1991-03-26 1997-11-24 Csl Ltd Use of veterinary implant as a single dose vaccination system: rupturable polymer film coating around core of active agent and water soluble excipient
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
JPH06508371A (ja) * 1991-06-21 1994-09-22 ユニバーシティー オブ シンシナティ 経口投与できる治療用タンパク質及びその製法
AU3582893A (en) * 1992-01-13 1993-08-03 Pitman-Moore, Inc. Delayed release device for transition metal/protein complexes
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
DE69305313T3 (de) * 1992-12-22 2001-06-21 The University Of Cincinnati, Cincinnati Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen Proteinen
KR100260632B1 (ko) * 1992-12-28 2000-07-01 성재갑 이식형 소마토트로핀 조성물
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
KR19990071255A (ko) 1998-02-28 1999-09-15 성재갑 소마토트로핀과 비타민의 합제 조성물
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
DE19820529A1 (de) * 1998-05-08 1999-11-11 Lohmann Therapie Syst Lts Wirkstoff enthaltende orale und mucosale Zubereitung mit steuerbarer Wirkstofffreisetzung und ihre Verwendung
EP1064934A1 (en) * 1999-06-30 2001-01-03 Applied Research Systems ARS Holding N.V. GRF-containing lyophilized pharmaceutical composition
CA2391707C (en) * 1999-07-30 2010-05-11 Smithkline Beecham Plc Multi-component pharmaceutical dosage form
AU2001271700A1 (en) * 2000-06-28 2002-01-08 Nitrosystems, Inc. Controlled release arginine formulations
AUPR602501A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR602401A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release delivery system
US20030050620A1 (en) * 2001-09-07 2003-03-13 Isa Odidi Combinatorial type controlled release drug delivery device
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
PL1824460T3 (pl) 2004-11-10 2015-09-30 Tolmar Therapeutics Inc Stabilizowany polimerowy układ dostarczania
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
EA201001002A1 (ru) * 2007-12-21 2011-06-30 Мерк Патент Гмбх Твердые липидные микрокапсулы, содержащие гормон роста во внутреннем твердом ядре
CN105476951A (zh) 2009-05-04 2016-04-13 普西维达公司 多孔硅药物洗脱颗粒
JP6026424B2 (ja) 2010-11-01 2016-11-16 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療薬送達のための生物浸食性ケイ素ベースのデバイス
WO2014151381A1 (en) 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) * 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4590062A (en) * 1984-04-16 1986-05-20 Tech Trade Corp. Dry direct compression compositions for controlled release dosage forms
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
JP2798248B2 (ja) * 1986-08-28 1998-09-17 コーテックス リミテッド 生物学的活性物質の動物の腸管部位へのデリバリーに有効なマイクロ顆粒状製剤
AU604052B2 (en) * 1986-08-28 1990-12-06 Enzacor Properties Limited Animal growth promotant
JP2792862B2 (ja) * 1988-07-30 1998-09-03 寛治 高田 経口腸溶製剤

Also Published As

Publication number Publication date
AU634529B2 (en) 1993-02-25
EP0463061A1 (en) 1992-01-02
EP0463061B1 (en) 1993-06-09
DE69001898T2 (de) 1993-09-23
DK0463061T3 (da) 1993-07-12
ATE90203T1 (de) 1993-06-15
AU5279290A (en) 1990-10-22
WO1990011070A1 (en) 1990-10-04
DE69001898D1 (de) 1993-07-15
NO913649L (no) 1991-09-16
NO913649D0 (no) 1991-09-16
JPH04504122A (ja) 1992-07-23

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