EA201001002A1 - Твердые липидные микрокапсулы, содержащие гормон роста во внутреннем твердом ядре - Google Patents
Твердые липидные микрокапсулы, содержащие гормон роста во внутреннем твердом ядреInfo
- Publication number
- EA201001002A1 EA201001002A1 EA201001002A EA201001002A EA201001002A1 EA 201001002 A1 EA201001002 A1 EA 201001002A1 EA 201001002 A EA201001002 A EA 201001002A EA 201001002 A EA201001002 A EA 201001002A EA 201001002 A1 EA201001002 A1 EA 201001002A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- solid
- growth hormones
- microcapsules containing
- containing growth
- internal
- Prior art date
Links
- 239000000122 growth hormone Substances 0.000 title abstract 4
- 239000007787 solid Substances 0.000 title 2
- 150000002632 lipids Chemical class 0.000 title 1
- 239000003094 microcapsule Substances 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 3
- 108010051696 Growth Hormone Proteins 0.000 abstract 3
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 2
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 2
- 239000000854 Human Growth Hormone Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение касается композиций гормона роста (GH), обладающих свойствами длительного высвобождения, в особенности человеческого гормона роста (hGH) и способов для их получения. Композиции гормона роста могут быть произведены без денатурации белка и могут легко вводиться пациенту, который в этом нуждается, с помощью обычного шприца через иглу, имеющую маленький диаметр.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07024906 | 2007-12-21 | ||
PCT/EP2008/009849 WO2009080164A1 (en) | 2007-12-21 | 2008-11-21 | Solid lipid microcapsules containing growth hormone in the inner solid core |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201001002A1 true EA201001002A1 (ru) | 2011-06-30 |
Family
ID=40566364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001002A EA201001002A1 (ru) | 2007-12-21 | 2008-11-21 | Твердые липидные микрокапсулы, содержащие гормон роста во внутреннем твердом ядре |
Country Status (15)
Country | Link |
---|---|
US (1) | US8729015B2 (ru) |
EP (1) | EP2231120B1 (ru) |
JP (1) | JP5773651B2 (ru) |
KR (1) | KR20100103846A (ru) |
CN (1) | CN101903014B (ru) |
AR (1) | AR069844A1 (ru) |
AT (1) | ATE514417T1 (ru) |
AU (1) | AU2008340785B8 (ru) |
BR (1) | BRPI0821359A2 (ru) |
CA (1) | CA2710062C (ru) |
EA (1) | EA201001002A1 (ru) |
ES (1) | ES2367093T3 (ru) |
IL (1) | IL206393A (ru) |
WO (1) | WO2009080164A1 (ru) |
ZA (1) | ZA201005167B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5773651B2 (ja) | 2007-12-21 | 2015-09-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル |
WO2010017965A2 (en) * | 2008-08-11 | 2010-02-18 | Merck Serono S.A. | SOLID LIPID MICROCAPSULES CONTAINING hGH |
CN102370630B (zh) * | 2010-08-11 | 2014-04-02 | 中国科学院过程工程研究所 | 重组人生长激素rhGH长效缓释微囊及其制备方法 |
CN103957898B (zh) | 2011-11-18 | 2016-02-24 | 瑞泽恩制药公司 | 聚合物蛋白微粒 |
EP4299058A3 (en) | 2014-06-24 | 2024-03-27 | The Trustees of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
KR101602138B1 (ko) | 2014-11-21 | 2016-03-10 | 강원대학교산학협력단 | 염화칼슘 미세입자가 봉입된 온도 의존성 고체지질입자 및 그 제조방법 |
AU2016378743A1 (en) * | 2015-12-22 | 2018-08-02 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
KR20170079409A (ko) * | 2015-12-30 | 2017-07-10 | 한미약품 주식회사 | 지속형 인간 성장 호르몬 결합체의 신규 액상 제제 |
CN109380730B (zh) * | 2017-08-09 | 2023-02-03 | 内蒙古伊利实业集团股份有限公司 | 微胶囊油脂及其制备方法 |
WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
CN114240934B (zh) * | 2022-02-21 | 2022-05-10 | 深圳大学 | 一种基于肢端肥大症的图像数据分析方法及系统 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6068044A (ja) * | 1983-09-24 | 1985-04-18 | Tetsuo Kato | 二重膜構造のマイクロカプセル |
US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
DK0463061T3 (da) * | 1989-03-17 | 1993-07-12 | Pitman Moore Inc | Controlled-release tilførselsindretning til afgivelse af makromolekylære proteiner |
US6544646B2 (en) * | 2000-04-27 | 2003-04-08 | Verion Inc. | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
US6967028B2 (en) * | 2000-07-31 | 2005-11-22 | Mainelab | Prolonged release microspheres for injectable administration |
FR2820319B3 (fr) * | 2001-02-08 | 2003-12-05 | Ellipse Pharmaceuticals | Procede de fabrication d'un comprime flottant incluant de l'alfuzosine et comprime obtenu |
CA2516339A1 (en) * | 2003-02-19 | 2004-09-02 | Takeda Pharmaceutical Company Limited | Dispersing agent for sustained-release preparation |
KR20170042364A (ko) * | 2006-06-05 | 2017-04-18 | 디에스엠 뉴트리셔널 프라덕츠 아게 | 개선된 쉘을 가지는 마이크로캡슐 |
JP5773651B2 (ja) | 2007-12-21 | 2015-09-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル |
-
2008
- 2008-11-21 JP JP2010538383A patent/JP5773651B2/ja not_active Expired - Fee Related
- 2008-11-21 AU AU2008340785A patent/AU2008340785B8/en not_active Ceased
- 2008-11-21 EA EA201001002A patent/EA201001002A1/ru unknown
- 2008-11-21 US US12/809,397 patent/US8729015B2/en not_active Expired - Fee Related
- 2008-11-21 CN CN200880121661.2A patent/CN101903014B/zh not_active Expired - Fee Related
- 2008-11-21 CA CA2710062A patent/CA2710062C/en not_active Expired - Fee Related
- 2008-11-21 BR BRPI0821359-3A patent/BRPI0821359A2/pt not_active IP Right Cessation
- 2008-11-21 KR KR1020107016389A patent/KR20100103846A/ko not_active Application Discontinuation
- 2008-11-21 AT AT08864968T patent/ATE514417T1/de not_active IP Right Cessation
- 2008-11-21 ES ES08864968T patent/ES2367093T3/es active Active
- 2008-11-21 EP EP08864968A patent/EP2231120B1/en not_active Not-in-force
- 2008-11-21 WO PCT/EP2008/009849 patent/WO2009080164A1/en active Application Filing
- 2008-12-19 AR ARP080105563A patent/AR069844A1/es unknown
-
2010
- 2010-06-15 IL IL206393A patent/IL206393A/en not_active IP Right Cessation
- 2010-07-20 ZA ZA2010/05167A patent/ZA201005167B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0821359A2 (pt) | 2015-06-16 |
EP2231120B1 (en) | 2011-06-29 |
ZA201005167B (en) | 2011-03-30 |
JP5773651B2 (ja) | 2015-09-02 |
WO2009080164A1 (en) | 2009-07-02 |
AR069844A1 (es) | 2010-02-24 |
CN101903014A (zh) | 2010-12-01 |
CN101903014B (zh) | 2014-04-16 |
CA2710062A1 (en) | 2009-07-02 |
CA2710062C (en) | 2016-05-31 |
US8729015B2 (en) | 2014-05-20 |
US20100310649A1 (en) | 2010-12-09 |
JP2011506499A (ja) | 2011-03-03 |
IL206393A0 (en) | 2010-12-30 |
AU2008340785B8 (en) | 2014-09-18 |
IL206393A (en) | 2015-06-30 |
AU2008340785A1 (en) | 2009-07-02 |
KR20100103846A (ko) | 2010-09-28 |
ATE514417T1 (de) | 2011-07-15 |
EP2231120A1 (en) | 2010-09-29 |
ES2367093T3 (es) | 2011-10-28 |
AU2008340785B2 (en) | 2014-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201001002A1 (ru) | Твердые липидные микрокапсулы, содержащие гормон роста во внутреннем твердом ядре | |
PE20142332A1 (es) | Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas | |
WO2007117509A3 (en) | High delivery rates for lipid based drug formulations, and methods of treatment thereof | |
WO2011109365A3 (en) | Concentrated protein formulations and uses thereof | |
EA200601761A1 (ru) | Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения | |
NO20075136L (no) | Nye liposompreparater | |
EA201300121A1 (ru) | Ингибитор дпп-4 в комбинации с дополнительным противодиабетическим агентом, таблетки, включающие указанные композиции, их применение и способ их получения | |
MX2009002314A (es) | Composiciones farmaceuticas que comprenden hgh para suministro oral. | |
ATE494889T1 (de) | Pharmazeutische kombination mit 3- (3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol und paracetamol | |
JP2013533268A5 (ru) | ||
EA201101706A1 (ru) | Лекарственное средство на основе дииндолилметана(dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека | |
NZ606993A (en) | Combination pharmaceutical composition and methods of treating and preventing the infectious diseases | |
WO2008109119A3 (en) | Wnt compositions and methods of use thereof | |
EA201101596A1 (ru) | Композиция для непрерывной доставки лекарственного средства, содержащая геополимерное связующее | |
TW200833367A (en) | Pharmaceutical compositions and method for treating inflammation in cattle and other animals | |
EA201101565A1 (ru) | Способы введения и составы для лечения регионарной жировой ткани | |
AR077611A1 (es) | Metodo y conjunto de elementos ( kit) para tratar la adiccion a la nicotina. combinacion. uso. | |
ES2570774T3 (es) | Uso de ácido araquidónico para reducir el riesgo de resistencia a la insulina más adelante en la vida | |
EA200800397A1 (ru) | Композиции тизанидина и способы лечения с применением композиций | |
EA200501821A1 (ru) | Фармацевтическая комбинация, содержащая модафинил и другой лекарственный препарат | |
WO2004112838A3 (en) | Codrugs of diclofenac | |
UA93365C2 (ru) | Инъекционная форма диклофенака и его фармацевтически приемлемых солей (варианты) и способ его приготовления (варианты) | |
MX2008015323A (es) | Composicion farmaceutica que comprende ciclobenzaprina y aceclofenac en asociacion. | |
WO2010017965A3 (en) | SOLID LIPID MICROCAPSULES CONTAINING hGH | |
ATE301452T1 (de) | Verfahren zur herstellung einer flüssigen dosierungseinheit und kit |